| THRA |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX | | |
| Ідентифікатори |
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| Символи | THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha |
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| Зовнішні ІД | OMIM: 190120 MGI: 98742 HomoloGene: 37747 GeneCards: THRA |
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| Пов'язані генетичні захворювання |
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| congenital nongoitrous hypothryoidism 6[1] |
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| Реагує на сполуку |
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| DL-3,3',5'-triiodothyronine, tiratricol, трийодтиронін, левотироксин[2] |
| Онтологія гена |
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| Молекулярна функція | • GO:0000975 transcription cis-regulatory region binding
• GO:0001948, GO:0016582 protein binding
• single-stranded RNA binding
• zinc ion binding
• chromatin DNA binding
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• steroid receptor RNA activator RNA binding
• transcription factor binding
• TBP-class protein binding
• steroid hormone receptor activity
• DNA binding
• protein domain specific binding
• sequence-specific DNA binding
• зв'язування з іоном металу
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• thyroid hormone binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0032403 protein-containing complex binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• nuclear receptor coactivator activity
• signaling receptor activity
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| Клітинна компонента | • цитоплазма
• нуклеоплазма
• клітинне ядро
• гіалоплазма
• RNA polymerase II transcription regulator complex
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| Біологічний процес | • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• response to cold
• cytoplasmic sequestering of transcription factor
• hormone-mediated signaling pathway
• regulation of thyroid hormone mediated signaling pathway
• thyroid gland development
• GO:0009373 regulation of transcription, DNA-templated
• осифікація
• female courtship behavior
• cartilage condensation
• negative regulation of RNA polymerase II transcription preinitiation complex assembly
• type I pneumocyte differentiation
• transcription, DNA-templated
• steroid hormone mediated signaling pathway
• transcription by RNA polymerase II
• regulation of lipid catabolic process
• regulation of heart contraction
• animal organ morphogenesis
• positive regulation of female receptivity
• learning or memory
• regulation of myeloid cell apoptotic process
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• transcription initiation from RNA polymerase II promoter
• erythrocyte differentiation
• negative regulation of DNA-templated transcription, initiation
• positive regulation of myotube differentiation
• GO:0045996 negative regulation of transcription, DNA-templated
• intracellular receptor signaling pathway
• GO:1901227 negative regulation of transcription by RNA polymerase II
• thyroid hormone mediated signaling pathway
• multicellular organism development
• brain development
• диференціація клітин
• response to lipid
• positive regulation of cold-induced thermogenesis
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_199334
NM_001190918
NM_001190919
NM_003250 |
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| RefSeq (білок) | | NP_001177847
NP_001177848
NP_003241
NP_955366 |
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| Локус (UCSC) | Хр. 17: 40.06 – 40.09 Mb | Хр. 11: 98.63 – 98.66 Mb |
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| PubMed search | [3] | [4] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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