Neuromedinski U receptor

Neuromedinski U receptor 1
Identifikatori
Simbol NMUR1
Alt. simboli GPR66
Entrez 10316
HUGO 4518
OMIM 604153
RefSeq NM_006056
UniProt Q9HB89
Drugi podaci
Lokus Hromozom 2 q37.1
Neuromedinski U receptor 2
Identifikatori
Simbol NMUR2
Alt. simboli NMU2R
Entrez 56923
HUGO 16454
OMIM 605108
RefSeq NM_020167
UniProt Q9GZQ4
Drugi podaci
Lokus Hromozom 5 q33.1

Neuromedinski U receptori su G protein spregnuti receptori koji vezuju neuropeptidne hormone neuromedin U i neuromedin S.[1] Postoje dva tipa neuromedin U receptora, koji su kodirani zasebnim genima (NMUR1, NMUR2).

Selektivni ligandi

Neuromedin U je agonist NMU1 i NMU2 tipa, dok je neuromedin S selektivan za NMU2, i on je potentniji agonist od neuromedina U.[2][3] Nekoliko drugih peptidnih i ne-peptidnih liganda NMU receptora je takođe poznato.

Agonisti

Neselektivni
  • Neuromedin U
  • ne-peptidni NMU modulatori[4][5]
NMU2 selektivni
  • Neuromedin S

Antagonisti

NMU2 selectivni

Literatura

  1. ↑ Brighton PJ, Szekeres PG, Willars GB (June 2004). „Neuromedin U and its receptors: structure, function, and physiological roles”. Pharmacological Reviews 56 (2): 231–48. DOI:10.1124/pr.56.2.3. PMID 15169928. 
  2. ↑ Mitchell J, Maguire J, Davenport A (June 2009). „Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S”. British Journal of Pharmacology 158 (1): 87–103. DOI:10.1111/j.1476-5381.2009.00252.x. PMC 2795236. PMID 19519756. 
  3. ↑ Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ (July 2009). „The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2)”. Endocrinology 150 (7): 3101–9. DOI:10.1210/en.2008-1772. PMC 2703546. PMID 19324999. 
  4. ↑ Meng T, Su HR, Binkert C, Fischli W, Zhou L, Shen JK, Wang MW (April 2008). „Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay”. Acta Pharmacologica Sinica 29 (4): 517–27. DOI:10.1111/j.1745-7254.2008.00769.x. PMID 18358099. 
  5. ↑ Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005
  6. ↑ Liu JJ, Payza K, Huang J, Liu R, Chen T, Coupal M, Laird JM, Cao CQ, Butterworth J, Lapointe S, Bayrakdarian M, Trivedi S, Bostwick JR (July 2009). „Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2”. The Journal of Pharmacology and Experimental Therapeutics 330 (1): 268–75. DOI:10.1124/jpet.109.152967. PMID 19369576. 

Spoljašnje veze

  • „Neuromedin U Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
  • MeSH Neuromedin+U+Receptor
  • p
  • r
  • u
Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
  • p
  • r
  • u
Neuropeptidni receptori
Hormonski receptori
Drugi
Opioidni receptori
Drugi neuropeptidni receptori
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)