Sigma-2 receptor
Sigma-2 receptor (σ2R) je sigma receptor koji preferentno vezuje siramesin[1] i PB28.[2]
Aktivacija ovog receptora može da uzrokuje apoptozu.[3] 3E farmakofor model sigma2 receptora baziran na seriji supstituisanih benzo[d]oksazol-2(3H)-on derivata je objavljen.[4]
Povezano
- Sigma receptor
- Sigma-1 receptor
Literatura
- ↑ Skuza G, Rogóz Z (2006). „The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats”. J. Physiol. Pharmacol. 57 (2): 217–29. PMID 16845227.
- ↑ Cassano G, Gasparre G, Contino M, et al (2006). „The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells”. Cell Calcium 40 (1): 23–8. DOI:10.1016/j.ceca.2006.03.004. PMID 16687172.
- ↑ Bowen WD (March 2000). „Sigma receptors: recent advances and new clinical potentials”. Pharm Acta Helv 74 (2–3): 211–8. DOI:10.1016/S0031-6865(99)00034-5. PMID 10812960.
- ↑ Laurini E, Zampieri D, Mamolo MG, Vio L, Zanette C, Florio C, Posocco P, Fermeglia M, Pricl S (May 2010). „A 3D-pharmacophore model for sigma2 receptors based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives”. Bioorg. Med. Chem. Lett. 20 (9): 2954–7. DOI:10.1016/j.bmcl.2010.03.009. PMID 20347592.
Spoljašnje veze
- MeSH sigma-2+receptor
- p
- r
- u
Neuropeptidni receptori
Hipotalamusni | |
---|---|
Drugi |
Angiotenzin - Bradikinin (B1, B2) / Tahikinin (TACR1) - Kalcitoninu sličan - Galanin - GPCR neuropeptid (B/W, FF, S, Y) - Neurotenzin
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)