EP1 receptor

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Prostaglandinski E receptor 1
Identifikatori
SimboliPTGER1; EP1
Vanjski IDOMIM: 176802 MGI: 97793 HomoloGene: 738 IUPHAR: EP1 GeneCards: PTGER1 Gene
Ontologija gena
Molekularna funkcija • aktivnost prostaglandinskog E receptora
Celularna komponenta • ćelijska membrana
• integralno sa ćelijskom membranom
Biološki proces • signalni put G-protein spregnutog receptora
• respons na lipopolisaharid
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez573119216
EnsemblENSG00000160951ENSMUSG00000019464
UniProtP34995P35375
RefSeq (mRNA)NM_000955.2NM_013641.2
RefSeq (protein)NP_000946.2NP_038669.1
Lokacija (UCSC)Chr 19:
14.58 - 14.59 Mb		Chr 8:
86.19 - 86.2 Mb
PubMed pretraga[1][2]

Prostaglandinski E receptor 1 (podtip EP1) je prostaglandinski receptor. PTGER1 je njegov ljudski gen.[1]

Ovaj protein je član familije G protein spregnutih receptora. On je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). Gq proteini posreduju aktivnost ovog receptora putem sistema fosfatidilinozitol-kalcijum sekundarnog glasnika. Ispitivanja na nokaut miševima sugeriraju da ovaj receptor posreduje algeziju, i učestvuje u regulaciji krvnog pritiska. Studije na miševima takođe pokazuju da ovaj gen posreduje adrenokortikotropni hormonski respons na bakterijski endotoksin.[1]

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa”. 

Literatura

  • Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166. 
  • Lee TY, Watanabe Y (1975). „A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems.”. Japanese heart journal 16 (3): 243–56. PMID 1160156. 
  • Duncan AM, Anderson LL, Funk CD, et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Funk CD, Furci L, FitzGerald GA, et al. (1994). „Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.”. J. Biol. Chem. 268 (35): 26767–72. PMID 8253813. 
  • Kurihara Y, Endo H, Kondo H (2001). „Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells.”. Inflamm. Res. 50 (1): 1–5. DOI:10.1007/s000110050716. PMID 11235015. 
  • Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.”. Mol. Vis. 8: 51–8. PMID 11951086. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Matsuoka Y, Furuyashiki T, Bito H, et al. (2003). „Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.”. Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–7. DOI:10.1073/pnas.0633341100. PMC 153060. PMID 12642666. 
  • Richards JA, Brueggemeier RW (2003). „Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.”. J. Clin. Endocrinol. Metab. 88 (6): 2810–6. DOI:10.1210/jc.2002-021475. PMID 12788892. 
  • Kitamura T, Itoh M, Noda T, et al. (2004). „Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.”. Cancer Sci. 94 (7): 618–21. DOI:10.1111/j.1349-7006.2003.tb01492.x. PMID 12841871. 
  • Moreland RB, Kim N, Nehra A, et al. (2004). „Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.”. Int. J. Impot. Res. 15 (5): 362–8. DOI:10.1038/sj.ijir.3901042. PMID 14562138. 
  • Su JL, Shih JY, Yen ML, et al. (2004). „Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.”. Cancer Res. 64 (2): 554–64. DOI:10.1158/0008-5472.CAN-03-1301. PMID 14744769. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Han C, Wu T (2005). „Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.”. J. Biol. Chem. 280 (25): 24053–63. DOI:10.1074/jbc.M500562200. PMID 15855163. 
  • Nicola C, Timoshenko AV, Dixon SJ, et al. (2005). „EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain.”. J. Clin. Endocrinol. Metab. 90 (8): 4736–46. DOI:10.1210/jc.2005-0413. PMID 15886234. 
  • Han C, Michalopoulos GK, Wu T (2006). „Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.”. J. Cell. Physiol. 207 (1): 261–70. DOI:10.1002/jcp.20560. PMID 16331686. 
  • Durrenberger PF, Facer P, Casula MA, et al. (2006). „Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.”. BMC neurology 6: 1. DOI:10.1186/1471-2377-6-1. PMC 1361784. PMID 16393343. 
  • McGraw DW, Mihlbachler KA, Schwarb MR, et al. (2006). „Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.”. J. Clin. Invest. 116 (5): 1400–9. DOI:10.1172/JCI25840. PMC 1451203. PMID 16670773. 
  • Horita H, Kuroda E, Hachisuga T, et al. (2007). „Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo.”. Hum. Reprod. 22 (7): 1801–9. DOI:10.1093/humrep/dem125. PMID 17525067. 

Vidi još

Spoljašnje veze

  • „Prostanoid Receptors: EP1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)