PDGFA

Platelet derived growth factor subunit A

معرفات

أسماء بديلة

PDGF-1, PDGFA, platelet-derived growth factor alpha chain, Platelet-derived growth factor A chain, platelet-derived growth factor A-chain, platelet-derived growth factor subunit A, platelet-derived growth factor alpha polypeptide, PDGF A-chain, PDGF subunit A

معرفات خارجية

تماثلات متسلسلة

أنواع

الإنسان

الفأر

أنتريه

n/a

Ensembl

n/a

يونيبروت


n/a


n/a

RefSeq (رنا مرسال.)


n/a


n/a

RefSeq (بروتين)


n/a


n/a

الموقع (UCSC

n/a

بحث ببمد

n/a

ويكي بيانات

اعرض/عدّل إنسان

PDGFA‏ (Platelet derived growth factor subunit A) هوَ بروتين يُشَفر بواسطة جين PDGFA في الإنسان.^[1]^[2]^[3]

الوظيفة

هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018)

الأهمية السريرية

هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018)

المراجع

^ Stenman G، Rorsman F، Huebner K، Betsholtz C (سبتمبر 1992). "The human platelet-derived growth factor alpha chain (PDGFA) gene maps to chromosome 7p22". Cytogenet Cell Genet. ج. 60 ع. 3–4: 206–7. DOI:10.1159/000133337. PMID:1505216.
^ Matsui T، Heidaran M، Miki T، Popescu N، La Rochelle W، Kraus M، Pierce J، Aaronson S (مارس 1989). "Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes". Science. ج. 243 ع. 4892: 800–4. DOI:10.1126/science.2536956. PMID:2536956.
^ "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide". مؤرشف من الأصل في 2010-12-05.

قراءة متعمقة

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Raines EW، Lane TF، Iruela-Arispe ML، وآخرون (1992). "The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors". Proc. Natl. Acad. Sci. U.S.A. ج. 89 ع. 4: 1281–5. DOI:10.1073/pnas.89.4.1281. PMC:48433. PMID:1311092.
Andersson M، Ostman A، Bäckström G، وآخرون (1992). "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF". J. Biol. Chem. ج. 267 ع. 16: 11260–6. PMID:1317862.
Rorsman F، Leveen P، Betsholtz C (1993). "Platelet-derived growth factor (PDGF) A-chain mRNA heterogeneity generated by the use of alternative promoters and alternative polyadenylation sites". Growth Factors. ج. 7 ع. 3: 241–51. DOI:10.3109/08977199209046928. PMID:1360804.
Wang Z، Lin XH، Qiu QQ، Deuel TF (1992). "Modulation of transcription of the platelet-derived growth factor A-chain gene by a promoter region sensitive to S1 nuclease". J. Biol. Chem. ج. 267 ع. 24: 17022–31. PMID:1512241.
Bonthron D، Collins T، Grzeschik KH، وآخرون (1992). "Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite". Genomics. ج. 13 ع. 2: 257–63. DOI:10.1016/0888-7543(92)90240-S. PMID:1612586.
Takimoto Y، Wang ZY، Kobler K، Deuel TF (1991). "Promoter region of the human platelet-derived growth factor A-chain gene". Proc. Natl. Acad. Sci. U.S.A. ج. 88 ع. 5: 1686–90. DOI:10.1073/pnas.88.5.1686. PMC:51089. PMID:1848007.
Fabisiak JP، Evans JN، Absher M، وآخرون (1991). "Expression of platelet-derived growth factor A-chain (PDGF-A) mRNA in lung tissue and cells. Complex regulation during remodeling". Chest. ج. 99 ع. 3 Suppl: 52S–54S. DOI:10.1378/chest.99.3_Supplement.52S. PMID:1997274.
Mendoza AE، Young R، Orkin SH، Collins T (1990). "Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy". Proc. Natl. Acad. Sci. U.S.A. ج. 87 ع. 6: 2177–81. DOI:10.1073/pnas.87.6.2177. PMC:53649. PMID:2315311.
Claesson-Welsh L، Eriksson A، Westermark B، Heldin CH (1989). "cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor". Proc. Natl. Acad. Sci. U.S.A. ج. 86 ع. 13: 4917–21. DOI:10.1073/pnas.86.13.4917. PMC:297526. PMID:2544881.
Rorsman F، Bywater M، Knott TJ، وآخرون (1988). "Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins". Mol. Cell. Biol. ج. 8 ع. 2: 571–7. PMC:363182. PMID:2832727.
Beckmann MP، Betsholtz C، Heldin CH، وآخرون (1988). "Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains". Science. ج. 241 ع. 4871: 1346–9. DOI:10.1126/science.2842868. PMID:2842868.
Bonthron DT، Morton CC، Orkin SH، Collins T (1988). "Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing". Proc. Natl. Acad. Sci. U.S.A. ج. 85 ع. 5: 1492–6. DOI:10.1073/pnas.85.5.1492. PMC:279797. PMID:3422746.
Tong BD، Auer DE، Jaye M، وآخرون (1987). "cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains". Nature. ج. 328 ع. 6131: 619–21. DOI:10.1038/328619a0. PMID:3614363.
Collins T، Bonthron DT، Orkin SH (1987). "Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain". Nature. ج. 328 ع. 6131: 621–4. DOI:10.1038/328621a0. PMID:3614364.
Hoppe J، Schumacher L، Eichner W، Weich HA (1987). "The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related". FEBS Lett. ج. 223 ع. 2: 243–6. DOI:10.1016/0014-5793(87)80297-1. PMID:3666150.
Betsholtz C، Johnsson A، Heldin CH، وآخرون (1986). "cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines". Nature. ج. 320 ع. 6064: 695–9. DOI:10.1038/320695a0. PMID:3754619.
Takimoto Y، Li WY، Wang ZY، وآخرون (1993). "Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene". Hiroshima J. Med. Sci. ج. 42 ع. 1: 47–52. PMID:8486521.