YM-254890
Chemical compound
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Formula | C46H69N7O15 |
Molar mass | 960.092 g·mol−1 |
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YM-254890 is a macrolide antibiotic derived from Chromobacterium species.[1][2][3][4] It is used as a pharmacological research compound which acts as a selective inhibitor of Gq mediated signalling.[5][6][7][8][9] However the claimed selectivity for Gq has been disputed.[10]
References
- ^ Mizuno N, Itoh H (2009). "Functions and regulatory mechanisms of Gq-signaling pathways". Neuro-Signals. 17 (1): 42–54. doi:10.1159/000186689. PMID 19212139. S2CID 556083.
- ^ Kamato D, Thach L, Bernard R, Chan V, Zheng W, Kaur H, et al. (2015). "Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11". Frontiers in Cardiovascular Medicine. 2: 14. doi:10.3389/fcvm.2015.00014. PMC 4671355. PMID 26664886.
- ^ Kamato D, Mitra P, Davis F, Osman N, Chaplin R, Cabot PJ, et al. (April 2017). "Gaq proteins: molecular pharmacology and therapeutic potential". Cellular and Molecular Life Sciences. 74 (8): 1379–1390. doi:10.1007/s00018-016-2405-9. PMC 11107756. PMID 27815595. S2CID 253596970.
- ^ Hermes C, König GM, Crüsemann M (December 2021). "The chromodepsins - chemistry, biology and biosynthesis of a selective Gq inhibitor natural product family". Natural Product Reports. 38 (12): 2276–2292. doi:10.1039/D1NP00005E. PMID 33998635. S2CID 234748014.
- ^ Xiong XF, Zhang H, Underwood CR, Harpsøe K, Gardella TJ, Wöldike MF, et al. (November 2016). "Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors". Nature Chemistry. 8 (11): 1035–1041. Bibcode:2016NatCh...8.1035X. doi:10.1038/nchem.2577. PMC 5559716. PMID 27768111.
- ^ Xiong XF, Zhang H, Boesgaard MW, Underwood CR, Bräuner-Osborne H, Strømgaard K (April 2019). "Structure-Activity Relationship Studies of the Natural Product Gq/11 Protein Inhibitor YM-254890". ChemMedChem. 14 (8): 865–870. doi:10.1002/cmdc.201900018. PMID 30790465. S2CID 73469968.
- ^ Li J, Ge Y, Huang JX, Strømgaard K, Zhang X, Xiong XF (May 2020). "Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery". Journal of Medicinal Chemistry. 63 (10): 5013–5030. doi:10.1021/acs.jmedchem.9b01452. PMID 31841625. S2CID 209389142.
- ^ Zhang H, Nielsen AL, Strømgaard K (January 2020). "Recent achievements in developing selective Gq inhibitors". Medicinal Research Reviews. 40 (1): 135–157. doi:10.1002/med.21598. PMID 31218731. S2CID 195192483.
- ^ Schlegel JG, Tahoun M, Seidinger A, Voss JH, Kuschak M, Kehraus S, et al. (April 2021). "Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890-Fit for Translation?". ACS Pharmacology & Translational Science. 4 (2): 888–897. doi:10.1021/acsptsci.1c00021. PMC 8033771. PMID 33860209. S2CID 233258488.
- ^ Peng Q, Shen J (2019). "YM-254890 is a General Inhibitor of G Proteins". The FASEB Journal. 33 (S1): 503.7. doi:10.1096/fasebj.2019.33.1_supplement.503.7. S2CID 241743171.
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