Protein-coding gene in the species Homo sapiens
UGT2A2 |
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Identifiers |
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Aliases | UGT2A2, UDP glucuronosyltransferase family 2 member A2, UDPGT 2A2 |
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External IDs | MGI: 3576095; HomoloGene: 115736; GeneCards: UGT2A2; OMA:UGT2A2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4q13.3 | Start | 69,588,417 bp[1] |
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End | 69,639,642 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 E1 | Start | 87,607,349 bp[2] |
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End | 87,630,119 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- olfactory zone of nasal mucosa
- right lobe of liver
- anterior pituitary
- human kidney
- renal cortex
- skin of abdomen
- skin of leg
- vagina
- wall of uterus
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| Top expressed in | - respiratory epithelium
- olfactory epithelium
- duodenum
- hepatobiliary system
- liver
- jejunum
- olfactory bulb
- integument
- skin
- human kidney
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - glycosyltransferase activity
- transferase activity
- glucuronosyltransferase activity
- hexosyltransferase activity
- UDP-glycosyltransferase activity
| Cellular component | - integral component of membrane
- intracellular membrane-bounded organelle
- membrane
| Biological process | - sensory perception of smell
- detection of chemical stimulus
- cellular glucuronidation
- response to stimulus
- metabolism
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | NP_001099147 NP_001288162 NP_001239203 NP_001239204 NP_001288168
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NP_006789 |
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Location (UCSC) | Chr 4: 69.59 – 69.64 Mb | Chr 5: 87.61 – 87.63 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.[5][6]
Function
The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[5] UGT2A1 and UGT2A2 were recently implicated as having a role in the loss of smell symptom associated with COVID-19.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000271271 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029268 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".
- ^ Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics. 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793.
- ^ Shelton, Janie F.; Shastri, Anjali J.; Aslibekyan, Stella; Auton, Adam; Auton, Adam (2021). "The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia | medRxiv". medRxiv 10.1101/2021.05.28.21257993v1.
2.4.1: Hexosyl- transferases | |
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2.4.2: Pentosyl- transferases | |
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2.4.99: Sialyl transferases | |
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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