UBOX5

Protein-coding gene in the species Homo sapiens
UBOX5
Identifiers
AliasesUBOX5, RNF37, UBCE7IP5, UIP5, hUIP5, U-box domain containing 5
External IDsMGI: 2154658; HomoloGene: 8972; GeneCards: UBOX5; OMA:UBOX5 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for UBOX5
Genomic location for UBOX5
Band20p13Start3,107,573 bp[1]
End3,160,196 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for UBOX5
Genomic location for UBOX5
Band2 F1|2Start130,431,922 bp[2]
End130,471,958 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • parotid gland

  • gastrocnemius muscle

  • muscle of thigh

  • skeletal muscle tissue

  • blood

  • Region I of hippocampus proper

  • popliteal artery

  • tibial arteries

  • inferior olivary nucleus
Top expressed in
  • otic vesicle

  • otic placode

  • spermatocyte

  • zygote

  • genital tubercle

  • female urethra

  • tail of embryo

  • maxillary prominence

  • mandibular prominence

  • saccule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ubiquitin-ubiquitin ligase activity
  • protein binding
  • ubiquitin protein ligase binding
  • metal ion binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
  • transferase activity
Cellular component
  • nuclear body
  • nucleus
  • nucleoplasm
  • focal adhesion
Biological process
  • protein polyubiquitination
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22888

140629

Ensembl

ENSG00000185019

ENSMUSG00000027300

UniProt

O94941

Q925F4

RefSeq (mRNA)

NM_199415
NM_001267584
NM_014948

NM_001255993
NM_001255994
NM_080562

RefSeq (protein)

NP_001254513
NP_055763
NP_955447

NP_001242922
NP_001242923
NP_542129

Location (UCSC)Chr 20: 3.11 – 3.16 MbChr 2: 130.43 – 130.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 37 is a protein that in humans is encoded by the UBOX5 gene.[5][6]

Interactions

UBOX5 has been shown to interact with UBE2L3.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185019 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027300 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Pringa E, Martinez-Noel G, Muller U, Harbers K (May 2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J Biol Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149.
  6. ^ "Entrez Gene: UBOX5 U-box domain containing 5".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  • Martinez-Noel G, Niedenthal R, Tamura T, Harbers K (1999). "A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4". FEBS Lett. 454 (3): 257–61. Bibcode:1999FEBSL.454..257M. doi:10.1016/S0014-5793(99)00823-6. PMID 10431818. S2CID 46159115.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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