SUV39H2

Protein-coding gene in the species Homo sapiens
SUV39H2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2R3A

Identifiers
AliasesSUV39H2, KMT1B, suppressor of variegation 3-9 homolog 2, SUV39H2 histone lysine methyltransferase
External IDsOMIM: 606503; MGI: 1890396; HomoloGene: 32548; GeneCards: SUV39H2; OMA:SUV39H2 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for SUV39H2
Genomic location for SUV39H2
Band10p13Start14,878,820 bp[1]
End14,904,315 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SUV39H2
Genomic location for SUV39H2
Band2 A1|2 1.95 cMStart3,456,852 bp[2]
End3,476,068 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • secondary oocyte

  • left testis

  • right testis

  • ventricular zone

  • ganglionic eminence

  • gonad

  • testicle

  • stromal cell of endometrium

  • islet of Langerhans
Top expressed in
  • tail of embryo

  • secondary oocyte

  • genital tubercle

  • zygote

  • spermatid

  • primary oocyte

  • ventricular zone

  • epiblast

  • primitive streak

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • methyltransferase activity
  • transferase activity
  • histone methyltransferase activity (H3-K9 specific)
  • transcription cis-regulatory region binding
  • metal ion binding
  • protein binding
  • histone-lysine N-methyltransferase activity
  • zinc ion binding
  • S-adenosyl-L-methionine binding
Cellular component
  • chromosome
  • nucleoplasm
  • chromatin
  • chromosome, centromeric region
  • nucleus
Biological process
  • chromatin remodeling
  • cell differentiation
  • regulation of transcription, DNA-templated
  • rhythmic process
  • histone H3-K9 dimethylation
  • negative regulation of circadian rhythm
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • histone H3-K9 trimethylation
  • methylation
  • histone lysine methylation
  • cell cycle
  • negative regulation of transcription, DNA-templated
  • cellular response to hypoxia
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79723

64707

Ensembl

ENSG00000152455

ENSMUSG00000026646

UniProt

Q9H5I1

Q9EQQ0

RefSeq (mRNA)

NM_001193424
NM_001193425
NM_001193426
NM_001193427
NM_024670

NM_022724

RefSeq (protein)

NP_001180353
NP_001180354
NP_001180355
NP_001180356
NP_078946

NP_073561

Location (UCSC)Chr 10: 14.88 – 14.9 MbChr 2: 3.46 – 3.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152455 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026646 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T (Dec 2000). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression". Mol Cell Biol. 20 (24): 9423–33. doi:10.1128/MCB.20.24.9423-9433.2000. PMC 102198. PMID 11094092.
  6. ^ "Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Rea S, Eisenhaber F, O'Carroll D, et al. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–9. doi:10.1038/35020506. PMID 10949293. S2CID 205008015.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ait-Si-Ali S, Guasconi V, Fritsch L, et al. (2005). "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells". EMBO J. 23 (3): 605–15. doi:10.1038/sj.emboj.7600074. PMC 1271807. PMID 14765126.
  • Frontelo P, Leader JE, Yoo N, et al. (2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression". Oncogene. 23 (30): 5242–51. doi:10.1038/sj.onc.1207660. PMID 15107829.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Yoon KA, Hwangbo B, Kim IJ, et al. (2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer". Carcinogenesis. 27 (11): 2217–22. doi:10.1093/carcin/bgl084. PMID 16774942.


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