RAB33B

Protein-coding gene in the species Homo sapiens

RAB33B

Identifiers

Aliases

RAB33B, SMC2, member RAS oncogene family

External IDs

OMIM: 605950; MGI: 1330805; HomoloGene: 9642; GeneCards: RAB33B; OMA:RAB33B - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q31.1	Start	139,453,232 bp^[1]
Band	4q31.1	End	139,476,609 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 C	Start	51,391,341 bp^[2]
Band	3\|3 C	End	51,403,653 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

saphenous vein

urethra

Region I of hippocampus proper

subthalamic nucleus

synovial joint

lateral nuclear group of thalamus

dorsal motor nucleus of vagus nerve

inferior olivary nucleus

superficial temporal artery

Top expressed in

transitional epithelium of urinary bladder

sciatic nerve

Ileal epithelium

iris

trigeminal ganglion

median eminence

ureter

vas deferens

medullary collecting duct

condyle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding nucleotide binding GTP binding GTPase activity
Cellular component	membrane Golgi lumen Golgi apparatus Golgi membrane presynapse endoplasmic reticulum membrane
Biological process	negative regulation of constitutive secretory pathway regulation of Golgi organization intra-Golgi vesicle-mediated transport regulation of epithelial cell proliferation regulation of retrograde vesicle-mediated transport, Golgi to ER protein transport skeletal system morphogenesis autophagy regulation of cell growth autophagosome assembly regulation of autophagosome assembly protein localization to Golgi apparatus intracellular protein transport endoplasmic reticulum to Golgi vesicle-mediated transport Rab protein signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


83452


19338

Ensembl


ENSG00000172007


ENSMUSG00000027739

UniProt


Q9H082


O35963

RefSeq (mRNA)


NM_031296


NM_016858

RefSeq (protein)


NP_112586


NP_058554

Location (UCSC)

Chr 4: 139.45 – 139.48 Mb

Chr 3: 51.39 – 51.4 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-33B is a protein that in humans is encoded by the RAB33B gene.^[5]

Mutations in this gene have been associated to cases of Dyggve-Melchior-Clausen syndrome.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172007 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027739 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "RAB33B, member RAS oncogene family".
^ Alshammari MJ, Al-Otaibi L, Alkuraya FS (May 2012). "Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve-Melchior-Clausen locus". J Med Genet. 49 (7): 455–61. doi:10.1136/jmedgenet-2011-100666. PMID 22652534. S2CID 206997124.

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Valsdottir R, Hashimoto H, Ashman K, et al. (2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Lett. 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. PMID 11718716. S2CID 21545088.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Zheng JY, Koda T, Fujiwara T, et al. (1998). "A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae". J. Cell Sci. 111 (8): 1061–9. doi:10.1242/jcs.111.8.1061. PMID 9512502.