PDZD4

Protein-coding gene in the species Homo sapiens
PDZD4
Identifiers
AliasesPDZD4, LU1, PDZK4, PDZRN4L, PDZ domain containing 4, LNX5
External IDsOMIM: 300634; MGI: 2443483; HomoloGene: 13046; GeneCards: PDZD4; OMA:PDZD4 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for PDZD4
Genomic location for PDZD4
BandXq28Start153,802,166 bp[1]
End153,830,565 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for PDZD4
Genomic location for PDZD4
BandX|X A7.3Start72,836,965 bp[2]
End72,868,575 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • cingulate gyrus

  • anterior cingulate cortex

  • Brodmann area 9

  • prefrontal cortex

  • amygdala

  • nucleus accumbens

  • caudate nucleus

  • putamen
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • supraoptic nucleus

  • primary visual cortex

  • epiblast

  • ascending aorta

  • otic vesicle

  • ganglionic eminence

  • hippocampus proper

  • cerebellar cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ubiquitin protein ligase activity
  • protein binding
Cellular component
  • cytoplasm
  • cell cortex
Biological process
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57595

245469

Ensembl

ENSG00000067840

ENSMUSG00000002006

UniProt

Q76G19
Q17RL8

Q9QY39

RefSeq (mRNA)
NM_032512
NM_001303512
NM_001303513
NM_001303514
NM_001303515

NM_001303516

NM_001029868
NM_001290540

RefSeq (protein)
NP_001290441
NP_001290442
NP_001290443
NP_001290444
NP_001290445

NP_115901
NP_001290441.1

NP_001025039
NP_001277469

Location (UCSC)Chr X: 153.8 – 153.83 MbChr X: 72.84 – 72.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PDZ domain-containing protein 4 is a protein that in humans is encoded by the PDZD4 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067840 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002006 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. ^ Nagayama S, Iiizumi M, Katagiri T, Toguchida J, Nakamura Y (Jul 2004). "Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas". Oncogene. 23 (32): 5551–7. doi:10.1038/sj.onc.1207710. PMID 15077175.
  7. ^ "Entrez Gene: PDZD4 PDZ domain containing 4".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Katoh M, Katoh M (2004). "Identification and characterization of human PDZRN4L gene and mouse Pdzrn4l gene in silico". Int. J. Mol. Med. 13 (6): 923–7. doi:10.3892/ijmm.13.6.923. PMID 15138636.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
  • Sandoval N, Bauer D, Brenner V, et al. (1996). "The genomic organization of a human creatine transporter (CRTR) gene located in Xq28". Genomics. 35 (2): 383–5. doi:10.1006/geno.1996.0373. PMID 8661155.


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