NLRC3 |
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Identifiers |
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Aliases | NLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3 |
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External IDs | OMIM: 615648; MGI: 2444070; HomoloGene: 18720; GeneCards: NLRC3; OMA:NLRC3 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16p13.3 | Start | 3,539,033 bp[1] |
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End | 3,577,403 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 16 (mouse)[2] |
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| Band | 16|16 A1 | Start | 3,762,871 bp[2] |
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End | 3,794,496 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - thymus
- granulocyte
- mucosa of ileum
- blood
- lymph node
- endothelial cell
- spleen
- appendix
- epithelium of nasopharynx
- tonsil
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| Top expressed in | - mesenteric lymph nodes
- blood
- thymus
- soleus muscle
- spleen
- lumbar subsegment of spinal cord
- stroma of bone marrow
- submandibular gland
- subcutaneous adipose tissue
- morula
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - nucleotide binding
- ATP binding
- protein binding
- phosphatidylinositol 3-kinase regulatory subunit binding
- molecular function
| Cellular component | - cytoplasm
- microtubule organizing center
- cytosol
- perinuclear region of cytoplasm
| Biological process | - negative regulation of interleukin-6 production
- negative regulation of tumor necrosis factor production
- I-kappaB kinase/NF-kappaB signaling
- negative regulation of NF-kappaB transcription factor activity
- T cell activation
- negative regulation of I-kappaB kinase/NF-kappaB signaling
- negative regulation of phosphatidylinositol 3-kinase signaling
- negative regulation of interferon-alpha production
- negative regulation of interferon-beta production
- negative regulation of innate immune response
- negative regulation of fibroblast proliferation
- negative regulation of epithelial cell proliferation
- negative regulation of inflammatory response
- negative regulation of cytokine production involved in inflammatory response
- negative regulation of NLRP3 inflammasome complex assembly
- negative regulation of NIK/NF-kappaB signaling
- intracellular signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 16: 3.54 – 3.58 Mb | Chr 16: 3.76 – 3.79 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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