Mir-449 microRNA precursor family

miR-449
Identifiers
Symbol	miR-449
Rfam	RF00711
miRBase family	MIPF0000133
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology, microRNAs function to regulate the expression levels of other genes by several mechanisms. The miR-449 microRNA family encompasses three homologous small RNA molecules (miR-449a/b/c). This miR-449 cluster is located in the second intron of the CDC20B gene which both are co-transcribed.^[1] This miR-449 family belongs to the miR-34/miR-449 superfamily of microRNAs that is composed of six homologous miRNAs, named miR-34a/b/c and miR-449a/b/c.^[1]^[2] They are grouped together in the same superfamily, as their seed region and their adjacent nucleotide sequences are largely conserved. The miR-449 miRNAs control the differentiation of multiciliated cells in vertebrates.^[1]^[2]

References

^ ^a ^b ^c Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P. (2011). ""Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway"". Nature Cell Biology. 13 (6): 693–9. doi:10.1038/ncb2241. PMID 21602795. S2CID 11514412.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ ^a ^b Ioannis Loukas, Margarita Skamnelou , Stavroula Tsaridou , Spyridoula Bournaka, Sokratis Grigoriadis, Stavros Taraviras, Zoi Lygerou and Marina Arbi (2021). "Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members". Biological Reviews. 96 (5): 2321–2332. doi:10.1111/brv.12755. PMID 34132477. S2CID 235449908.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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