MIZF

Protein-coding gene in the species Homo sapiens

HINFP
Identifiers
AliasesHINFP, HiNF-P, MIZF, ZNF743, histone H4 transcription factor
External IDsOMIM: 607099; MGI: 2429620; HomoloGene: 9174; GeneCards: HINFP; OMA:HINFP - orthologs
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[1]
Chromosome 9 (mouse)
Genomic location for HINFP
Genomic location for HINFP
Band9|9 A5.2Start44,203,737 bp[1]
End44,216,968 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
Top expressed in
  • neural layer of retina

  • ascending aorta

  • aortic valve

  • granulocyte

  • Rostral migratory stream

  • spermatocyte

  • yolk sac

  • ventricular zone

  • tail of embryo

  • zygote
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • transcription coactivator activity
  • histone binding
  • metal ion binding
  • protein binding
  • nucleic acid binding
  • enzyme binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • chromatin binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • Cajal body
  • nucleoplasm
  • nucleolus
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • establishment of protein localization
  • DNA damage checkpoint signaling
  • regulation of transcription involved in G1/S transition of mitotic cell cycle
  • negative regulation of gene expression
  • transcription, DNA-templated
  • regulation of gene expression
  • myoblast differentiation
  • negative regulation of transcription, DNA-templated
  • DNA repair
  • negative regulation of transcription by RNA polymerase II
  • in utero embryonic development
  • positive regulation of gene expression
  • positive regulation of transcription, DNA-templated
  • G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25988

102423

Ensembl

ENSG00000172273

ENSMUSG00000032119

UniProt

Q9BQA5

Q8K1K9

RefSeq (mRNA)

NM_001243259
NM_015517
NM_198971

NM_172162

RefSeq (protein)
NP_001230188
NP_056332
NP_945322
NP_001338886
NP_001338887

NP_001338888
NP_001338889
NP_001338890
NP_001338891
NP_001338892
NP_001338893
NP_001338894
NP_001338895
NP_001338898
NP_001338900
NP_001338901
NP_001338903

NP_751894
NP_001391993
NP_001391994
NP_001391995

Location (UCSC)n/aChr 9: 44.2 – 44.22 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene.[4][5]

Function

HINFP is a protein that binds to a highly conserved DNA motif found in most histone H4 genes. HINFP activates H4 gene expression through interactions with the CDK2 substrate NPAT which is localized in Histone Locus Bodies. HINFP was independently described as a protein called "MBD2 interacting zinc finger protein" (MIZF). MIZF was reported to interact with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex. MIZF is thought to play a role in DNA methylation and transcription repression.[supplied by OMIM][5]

Interactions

One key partner protein of HINFP is NPAT, a CDK2 substrate that localizes to Histone Locus Bodies. MIZF has been reported to interact with Methyl-CpG-binding domain protein 2[4] and DHX9.[6]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032119 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (November 2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.
  5. ^ a b "Entrez Gene: MIZF MBD2-interacting zinc finger".
  6. ^ Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A, Nakajima T (April 2003). "Antithetic effects of MBD2a on gene regulation". Mol. Cell. Biol. 23 (8): 2645–57. doi:10.1128/MCB.23.8.2645-2657.2003. PMC 152551. PMID 12665568.

Further reading

  • Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS (2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes". Cancer Res. 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.
  • Mitra P, Xie R, Harper JW, Stein JL, Stein GS, van Wijnen AJ (2007). "HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription". J. Cell. Biochem. 101 (1): 181–91. doi:10.1002/jcb.21157. PMID 17163457. S2CID 23552843.
  • Fukushige S, Kondo E, Gu Z, Suzuki H, Horii A (2006). "RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression". Biochem. Biophys. Res. Commun. 351 (1): 85–92. doi:10.1016/j.bbrc.2006.10.005. PMID 17049487.
  • Pulukuri SM, Rao JS (2006). "CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2". Oncogene. 25 (33): 4559–72. doi:10.1038/sj.onc.1209462. PMC 1526774. PMID 16786000.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Miele A, Braastad CD, Holmes WF, Mitra P, Medina R, Xie R, Zaidi SK, Ye X, Wei Y, Harper JW, van Wijnen AJ, Stein JL, Stein GS (2005). "HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition". Mol. Cell. Biol. 25 (14): 6140–53. doi:10.1128/MCB.25.14.6140-6153.2005. PMC 1168814. PMID 15988025.
  • Sekimata M, Homma Y (2004). "Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation". Biochem. Biophys. Res. Commun. 325 (3): 653–9. doi:10.1016/j.bbrc.2004.10.090. PMID 15541338.
  • Sekimata M, Homma Y (2004). "Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF". Nucleic Acids Res. 32 (2): 590–7. doi:10.1093/nar/gkh249. PMC 373363. PMID 14752047.
  • Mitra P, Xie RL, Medina R, Hovhannisyan H, Zaidi SK, Wei Y, Harper JW, Stein JL, van Wijnen AJ, Stein GS (2003). "Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase". Mol. Cell. Biol. 23 (22): 8110–23. doi:10.1128/MCB.23.22.8110-8123.2003. PMC 262391. PMID 14585971.


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