KLC2

Protein-coding gene in the species Homo sapiens

KLC2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3CEQ, 3EDT

Identifiers

Aliases

KLC2, kinesin light chain 2

External IDs

OMIM: 611729; MGI: 107953; HomoloGene: 22468; GeneCards: KLC2; OMA:KLC2 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.2	Start	66,257,294 bp^[1]
Band	11q13.2	End	66,267,860 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19 A\|19 4.25 cM	Start	5,157,774 bp^[2]
Band	19 A\|19 4.25 cM	End	5,168,588 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

right frontal lobe

prefrontal cortex

Brodmann area 9

anterior cingulate cortex

right testis

endothelial cell

left testis

anterior pituitary

primary visual cortex

Top expressed in

superior frontal gyrus

primary visual cortex

cerebellar cortex

dentate gyrus of hippocampal formation granule cell

neural layer of retina

pontine nuclei

superior colliculus

inferior colliculus

muscle of thigh

medulla oblongata

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	microtubule motor activity protein binding kinesin binding cadherin binding
Cellular component	cytoplasm cytosol microtubule cytoskeleton membrane kinesin I complex kinesin complex nucleoplasm mitochondrion plasma membrane protein-containing complex
Biological process	microtubule-based movement antigen processing and presentation of exogenous peptide antigen via MHC class II retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64837


16594

Ensembl


ENSG00000174996


ENSMUSG00000024862

UniProt


Q9H0B6


O88448

RefSeq (mRNA)


NM_001134774 NM_001134775 NM_001134776 NM_022822 NM_001318734


NM_008451 NM_001369360 NM_001369361 NM_001369362

RefSeq (protein)


NP_001128246 NP_001128247 NP_001128248 NP_001305663 NP_073733


n/a

Location (UCSC)

Chr 11: 66.26 – 66.27 Mb

Chr 19: 5.16 – 5.17 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.^[5]^[6]

Interactions

KLC2 has been shown to interact with MAPK8IP3^[7] and KIF5B.^[5]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174996 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024862 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122.
^ "Entrez Gene: KLC2 kinesin light chain 2".
^ Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. S2CID 247102.
^ Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.

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