IL12B |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Protein_IL12B_PDB_1f42.png/250px-Protein_IL12B_PDB_1f42.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1F42, 1F45, 3D85, 3D87, 3DUH, 3HMX, 3QWR, 4GRW, 4OE8, 4OG9 |
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Identifiers |
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Aliases | IL12B, CLMF, CLMF2, IL-12B, IMD28, NKSF, NKSF2, IMD29, Interleukin 12 subunit beta, interleukin 12B |
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External IDs | OMIM: 161561; MGI: 96540; HomoloGene: 1648; GeneCards: IL12B; OMA:IL12B - orthologs |
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Gene location (Human) |
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![Chromosome 5 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png) | Chr. | Chromosome 5 (human)[1] |
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| Band | 5q33.3 | Start | 159,314,780 bp[1] |
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End | 159,330,863 bp[1] |
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Gene location (Mouse) |
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![Chromosome 11 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11 B1.1|11 25.94 cM | Start | 44,290,890 bp[2] |
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End | 44,304,860 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- lymph node
- pituitary gland
- appendix
- tibialis anterior muscle
- anterior pituitary
- rectum
- gallbladder
- human kidney
- olfactory zone of nasal mucosa
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| Top expressed in | - embryo
- lumbar subsegment of spinal cord
- thymus
- tracheobronchial tree
- tibiofemoral joint
- spleen
- trachea
- right kidney
- gastrula
- carotid body
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/e/e3/PBB_GE_IL12B_207901_at_fs.png/250px-PBB_GE_IL12B_207901_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - cytokine activity
- interleukin-23 receptor binding
- protein homodimerization activity
- interleukin-12 receptor binding
- protein binding
- identical protein binding
- protein heterodimerization activity
- interleukin-12 alpha subunit binding
- cytokine receptor activity
- growth factor activity
- cytokine receptor binding
- cytokine binding
| Cellular component | - cytoplasm
- membrane
- interleukin-12 complex
- interleukin-23 complex
- extracellular region
- extracellular space
- endoplasmic reticulum lumen
- cytosol
- late endosome lumen
- cell surface
- external side of plasma membrane
- receptor complex
| Biological process | - positive regulation of cell adhesion
- negative regulation of interleukin-10 production
- negative regulation of smooth muscle cell proliferation
- positive regulation of inflammatory response
- sexual reproduction
- positive regulation of interleukin-12 production
- positive regulation of smooth muscle cell apoptotic process
- defense response to Gram-negative bacterium
- positive regulation of interleukin-10 production
- positive regulation of T cell mediated cytotoxicity
- natural killer cell activation
- positive regulation of natural killer cell activation
- positive regulation of interferon-gamma production
- positive regulation of osteoclast differentiation
- positive regulation of T-helper 17 cell lineage commitment
- response to organic substance
- positive regulation of NK T cell activation
- positive regulation of natural killer cell proliferation
- natural killer cell activation involved in immune response
- cell surface receptor signaling pathway
- positive regulation of NK T cell proliferation
- positive regulation of T-helper 17 type immune response
- negative regulation of inflammatory response to antigenic stimulus
- defense response to virus
- positive regulation of tissue remodeling
- positive regulation of T-helper 1 type immune response
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- positive regulation of granulocyte macrophage colony-stimulating factor production
- positive regulation of T cell proliferation
- positive regulation of memory T cell differentiation
- cellular response to interferon-gamma
- positive regulation of tumor necrosis factor production
- T-helper 1 type immune response
- sensory perception of pain
- response to UV-B
- positive regulation of interleukin-17 production
- cellular response to lipopolysaccharide
- negative regulation of interleukin-17 production
- T-helper cell differentiation
- cell migration
- positive regulation of lymphocyte proliferation
- positive regulation of mononuclear cell proliferation
- positive regulation of activated T cell proliferation
- defense response to protozoan
- positive regulation of defense response to virus by host
- positive regulation of activation of Janus kinase activity
- regulation of tyrosine phosphorylation of STAT protein
- positive regulation of tyrosine phosphorylation of STAT protein
- interleukin-12-mediated signaling pathway
- cell population proliferation
- regulation of signaling receptor activity
- T-helper 1 cell cytokine production
- cytokine-mediated signaling pathway
- interleukin-23-mediated signaling pathway
- positive regulation of NIK/NF-kappaB signaling
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 5: 159.31 – 159.33 Mb | Chr 11: 44.29 – 44.3 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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