Integrin beta 5

Protein-coding gene in the species Homo sapiens
ITGB5
Identifiers
AliasesITGB5, Integrin, beta 5, integrin subunit beta 5
External IDsOMIM: 147561; MGI: 96614; HomoloGene: 20511; GeneCards: ITGB5; OMA:ITGB5 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ITGB5
Genomic location for ITGB5
Band3q21.2Start124,761,948 bp[1]
End124,901,418 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for ITGB5
Genomic location for ITGB5
Band16|16 B3Start33,650,035 bp[2]
End33,769,708 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • right coronary artery

  • ascending aorta

  • Descending thoracic aorta

  • pancreatic ductal cell

  • tendon of biceps brachii

  • cartilage tissue

  • left coronary artery

  • metanephric glomerulus

  • popliteal artery
Top expressed in
  • tunica media of zone of aorta

  • epithelium of lens

  • decidua

  • calvaria

  • ciliary body

  • molar

  • external carotid artery

  • gastrula

  • stria vascularis

  • stroma of bone marrow
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • virus receptor activity
  • protein binding
  • integrin binding
  • signaling receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • focal adhesion
  • receptor complex
  • plasma membrane
  • cell surface
  • integrin complex
  • phagocytic vesicle
  • integrin alphav-beta5 complex
  • extracellular exosome
Biological process
  • muscle contraction
  • endodermal cell differentiation
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • extracellular matrix organization
  • epithelial cell-cell adhesion
  • stress fiber assembly
  • cell adhesion
  • integrin-mediated signaling pathway
  • viral entry into host cell
  • cell-matrix adhesion
  • viral process
  • transforming growth factor beta receptor signaling pathway
  • cell migration
  • cell adhesion mediated by integrin
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3693

16419

Ensembl

ENSG00000082781

ENSMUSG00000022817

UniProt

P18084

O70309

RefSeq (mRNA)

NM_002213
NM_001354764
NM_001354765
NM_001354766

NM_001145884
NM_010580

RefSeq (protein)

NP_002204
NP_001341693
NP_001341694
NP_001341695

NP_001139356
NP_034710
NP_001391992

Location (UCSC)Chr 3: 124.76 – 124.9 MbChr 16: 33.65 – 33.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]

Interactions

Integrin, beta 5 has been shown to interact with PTK2,[7] Annexin A5[8] and PAK4.[9]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[10]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000082781 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022817 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi:10.1016/S0021-9258(17)44878-2. PMID 2211615.
  6. ^ "Entrez Gene: ITGB5 integrin, beta 5".
  7. ^ Eliceiri BP, Puente Xose S, Hood John D, Stupack Dwayne G, Schlaepfer David D, Huang Xiaozhu Z, Sheppard Dean, Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
  8. ^ Cardó-Vila M, Arap Wadih, Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.
  9. ^ Zhang H, Li Zhilun, Viklund Eva-Karin, Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.
  10. ^ Zhang Ly, Guo Q, Guan Gf, Cheng W, Cheng P, Wu Ah (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi:10.3389/fonc.2019.00904. ISSN 2234-943X. PMC 6764112. PMID 31616629.
  11. ^ Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. S2CID 5097233.

Further reading

  • Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216. S2CID 23712246.
  • Smith JW, Vestal DJ, Irwin SV, et al. (1990). "Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin". J. Biol. Chem. 265 (19): 11008–13. doi:10.1016/S0021-9258(19)38549-7. PMID 1694173.
  • Adams JC, Watt FM (1991). "Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes". J. Cell Biol. 115 (3): 829–41. doi:10.1083/jcb.115.3.829. PMC 2289188. PMID 1918165.
  • Ramaswamy H, Hemler ME (1990). "Cloning, primary structure and properties of a novel human integrin beta subunit". EMBO J. 9 (5): 1561–8. doi:10.1002/j.1460-2075.1990.tb08275.x. PMC 551850. PMID 2328726.
  • Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit". Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5354–8. Bibcode:1990PNAS...87.5354S. doi:10.1073/pnas.87.14.5354. PMC 54322. PMID 2371275.
  • Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5". J. Biol. Chem. 270 (44): 26232–8. doi:10.1074/jbc.270.44.26232. PMID 7592829.
  • Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin". J. Cell Biol. 121 (2): 461–8. doi:10.1083/jcb.121.2.461. PMC 2200091. PMID 7682219.
  • Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies". J. Cell Sci. 105 (1): 101–11. doi:10.1242/jcs.105.1.101. PMID 7689573.
  • Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes". Journal of Immunology. 157 (3): 974–7. doi:10.4049/jimmunol.157.3.974. PMID 8757599.
  • Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney". Am. J. Nephrol. 16 (5): 402–8. doi:10.1159/000169032. PMID 8886177.
  • Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
  • Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin". J. Cell Sci. 111 (4): 425–33. doi:10.1242/jcs.111.4.425. PMID 9443892.
  • Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing". Biochem. J. 331 (2): 631–7. doi:10.1042/bj3310631. PMC 1219398. PMID 9531507.
  • Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin". Journal of Immunology. 163 (4): 1929–35. doi:10.4049/jimmunol.163.4.1929. PMID 10438928.
  • Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer". Cancer Res. 59 (20): 5307–14. PMID 10537314.
  • Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726.
  • Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells". J. Cell Biol. 150 (6): 1445–60. doi:10.1083/jcb.150.6.1445. PMC 2150716. PMID 10995448.
  • Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654. S2CID 7535200.
  • Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.
  • Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur J Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.
  • ITGB5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
  • v
  • t
  • e
AlphaBetaDimers
Cytoadhesin receptor:
Fibrinogen receptor:
Fibronectin receptor:
Leukocyte-adhesion receptor:
Very late antigen receptor:
Vitronectin receptor:
see also cell surface receptor deficiencies


Stub icon

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e