INSRR

Protein-coding gene in the species Homo sapiens
INSRR
Identifiers
AliasesINSRR, IRR, insulin receptor related receptor
External IDsOMIM: 147671; MGI: 1346037; HomoloGene: 56539; GeneCards: INSRR; OMA:INSRR - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for INSRR
Genomic location for INSRR
Band1q23.1Start156,840,063 bp[1]
End156,859,117 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for INSRR
Genomic location for INSRR
Band3 F1|3 38.7 cMStart87,704,258 bp[2]
End87,723,408 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of stomach

  • human kidney

  • body of uterus

  • right testis

  • apex of heart

  • myometrium

  • canal of the cervix

  • fundus

  • left testis

  • abdominal wall
Top expressed in
  • islet of Langerhans

  • right kidney

  • cingulate gyrus

  • embryo

  • internal carotid artery

  • external carotid artery

  • central gray substance of midbrain

  • glossopharyngeal ganglion

  • nucleus of stria terminalis

  • human kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transmembrane receptor protein tyrosine kinase activity
  • phosphatidylinositol 3-kinase binding
  • insulin receptor substrate binding
  • nucleotide binding
  • protein kinase activity
  • protein tyrosine kinase activity
  • transferase activity
  • ATP binding
  • kinase activity
  • receptor tyrosine kinase
  • transmembrane signaling receptor activity
  • insulin-activated receptor activity
Cellular component
  • receptor complex
  • integral component of membrane
  • integral component of plasma membrane
  • membrane
  • cytoplasm
  • insulin receptor complex
  • axon
Biological process
  • actin cytoskeleton reorganization
  • protein autophosphorylation
  • protein phosphorylation
  • cellular response to alkaline pH
  • male sex determination
  • phosphorylation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • peptidyl-tyrosine phosphorylation
  • insulin receptor signaling pathway
  • negative regulation of signal transduction
  • cell differentiation
  • glucose homeostasis
  • negative regulation of apoptotic process
  • positive regulation of ERK1 and ERK2 cascade
  • anatomical structure development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3645

23920

Ensembl

ENSG00000027644

ENSMUSG00000005640

UniProt

P14616

Q9WTL4

RefSeq (mRNA)

NM_014215

NM_011832

RefSeq (protein)

NP_055030

NP_035962

Location (UCSC)Chr 1: 156.84 – 156.86 MbChr 3: 87.7 – 87.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000027644 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005640 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem. 264 (25): 14605–8. doi:10.1016/S0021-9258(18)63737-8. PMID 2768234.
  6. ^ Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet. 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481.
  7. ^ "Entrez Gene: INSRR insulin receptor-related receptor".

Further reading

  • Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities". J. Biol. Chem. 267 (26): 18320–8. doi:10.1016/S0021-9258(19)36963-7. PMID 1326521.
  • Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney". Endocrinology. 136 (9): 4125–32. doi:10.1210/endo.136.9.7649121. PMID 7649121.
  • Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas". J. Biol. Chem. 270 (4): 1881–7. doi:10.1074/jbc.270.4.1881. PMID 7829525.
  • Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells". Biochemistry. 35 (45): 14326–30. doi:10.1021/bi9613032. PMID 8916919.
  • Hänze J, Berthold A, Klammt J, Gallaher B, Siebler T, Kratzsch J, Elmlinger M, Kiess W (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor". Horm. Metab. Res. 31 (2–3): 77–9. doi:10.1055/s-2007-978702. PMID 10226785. S2CID 260167556.
  • Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins". J. Biol. Chem. 274 (21): 15262–70. doi:10.1074/jbc.274.21.15262. PMID 10329736.
  • Elmlinger MW, Rauschnabel U, Koscielniak E, Haenze J, Ranke MB, Berthold A, Klammt J, Kiess W (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin". Regul. Pept. 84 (1–3): 37–42. doi:10.1016/S0167-0115(99)00065-8. PMID 10535406. S2CID 664805.
  • Whitmore TE, Maurer MF, Day HL, Jelmberg A, Dasovich M, Sundborg L, Burkhead S, Heipel M, Madden K (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping". Cytogenet. Cell Genet. 87 (1–2): 93–4. doi:10.1159/000015400. PMID 10640820. S2CID 36476566.
  • Weber A, Huesken C, Bergmann E, Kiess W, Christiansen NM, Christiansen H (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552.
  • Klammt J, Garten A, Barnikol-Oettler A, Beck-Sickinger AG, Kiess W (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:10.1016/j.bbrc.2004.12.039. PMID 15629149.
  • Dissen GA, Garcia-Rudaz C, Tapia V, Parada LF, Hsu SY, Ojeda SR (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary". Endocrinology. 147 (1): 155–65. doi:10.1210/en.2005-0386. PMID 16195402.
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