Ets variant 2

Protein-coding gene in the species Homo sapiens
ETV2
Identifiers
AliasesETV2, ER71, ETSRP71, Ets variant 2, ETS variant transcription factor 2
External IDsOMIM: 609358; MGI: 99253; HomoloGene: 7308; GeneCards: ETV2; OMA:ETV2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ETV2
Genomic location for ETV2
Band19q13.12Start35,641,745 bp[1]
End35,644,871 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ETV2
Genomic location for ETV2
Band7|7 B1Start30,333,041 bp[2]
End30,335,277 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • testicle

  • mucosa of transverse colon

  • stromal cell of endometrium

  • granulocyte

  • right lobe of liver

  • skin of abdomen

  • body of pancreas

  • skin of leg
Top expressed in
  • embryo

  • urethra

  • male urethra

  • primitive streak

  • morula

  • epiblast

  • embryo

  • seminiferous tubule

  • blastocyst

  • pharynx
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • Notch signaling pathway
  • cell differentiation
  • positive regulation of endothelial cell differentiation
  • regulation of transcription, DNA-templated
  • blood vessel morphogenesis
  • placenta development
  • regulation of transcription by RNA polymerase II
  • mesoderm formation
  • in utero embryonic development
  • Wnt signaling pathway
  • transcription by RNA polymerase II
  • positive regulation of mesoderm development
  • positive regulation of gene expression
  • BMP signaling pathway involved in mesodermal cell fate specification
  • erythrocyte differentiation
  • blastocyst development
  • positive regulation of transcription by RNA polymerase II
  • hemopoiesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2116

14008

Ensembl

ENSG00000105672

ENSMUSG00000006311

UniProt

O00321

P41163

RefSeq (mRNA)

NM_001300974
NM_001304549
NM_014209

NM_007959

RefSeq (protein)

NP_001287903
NP_001291478
NP_055024

NP_031985

Location (UCSC)Chr 19: 35.64 – 35.64 MbChr 7: 30.33 – 30.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ets variant 2 is a protein that in humans is encoded by the ETV2 gene.[5] It is a transcription factor and also plays a role in vascular endothelial cell development.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105672 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006311 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ets variant 2".
  6. ^ Oh SY, Kim JY, Park C (December 2015). "The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development". Molecules and Cells. 38 (12): 1029–36. doi:10.14348/molcells.2015.0331. PMC 4696993. PMID 26694034.
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