ERLIN2

Protein-coding gene in the species Homo sapiens
ERLIN2
Identifiers
AliasesERLIN2, C8orf2, Erlin-2, NET32, SPFH2, SPG18, ER lipid raft associated 2
External IDsOMIM: 611605; MGI: 2387215; HomoloGene: 5193; GeneCards: ERLIN2; OMA:ERLIN2 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ERLIN2
Genomic location for ERLIN2
Band8p11.23Start37,736,601 bp[1]
End37,758,422 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for ERLIN2
Genomic location for ERLIN2
Band8|8 A2Start27,513,289 bp[2]
End27,530,356 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Epithelium of choroid plexus

  • renal medulla

  • Achilles tendon

  • islet of Langerhans

  • parotid gland

  • germinal epithelium

  • mucosa of paranasal sinus

  • bronchial epithelial cell

  • kidney tubule

  • caput epididymis
Top expressed in
  • spermatocyte

  • otolith organ

  • utricle

  • Epithelium of choroid plexus

  • right kidney

  • vestibular membrane of cochlear duct

  • decidua

  • superior cervical ganglion

  • gastrula

  • proximal tubule
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • cholesterol binding
  • protein binding
  • protein tyrosine kinase activity
  • ubiquitin protein ligase binding
Cellular component
  • integral component of membrane
  • membrane raft
  • membrane
  • endoplasmic reticulum
  • plasma membrane
  • endoplasmic reticulum membrane
  • cytosol
  • protein-containing complex
Biological process
  • SREBP signaling pathway
  • steroid metabolic process
  • cholesterol metabolic process
  • negative regulation of cholesterol biosynthetic process
  • negative regulation of fatty acid biosynthetic process
  • lipid metabolism
  • ubiquitin-dependent ERAD pathway
  • peptidyl-tyrosine phosphorylation
  • transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11160

244373

Ensembl

ENSG00000147475

ENSMUSG00000031483

UniProt

O94905

Q8BFZ9

RefSeq (mRNA)

NM_001003790
NM_001003791
NM_007175
NM_001362878
NM_001362880

NM_153592
NM_001364476
NM_001364477
NM_001379175
NM_001379176

NM_001379177
NM_001379178

RefSeq (protein)

NP_001003790
NP_001003791
NP_009106
NP_001349807
NP_001349809

NP_705820
NP_001351405
NP_001351406
NP_001366104
NP_001366105

NP_001366106
NP_001366107
NP_001391043
NP_001391044
NP_001391045

Location (UCSC)Chr 8: 37.74 – 37.76 MbChr 8: 27.51 – 27.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene.[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147475 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031483 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenetics and Cell Genetics. 85 (3–4): 227–31. doi:10.1159/000015298. PMID 10449903. S2CID 39559998.
  6. ^ Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes". Oncogene. 24 (33): 5235–45. doi:10.1038/sj.onc.1208741. PMID 15897872.
  7. ^ Browman DT, Resek ME, Zajchowski LD, Robbins SM (Aug 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". Journal of Cell Science. 119 (Pt 15): 3149–60. doi:10.1242/jcs.03060. PMID 16835267.
  8. ^ "Entrez Gene: ERLIN2 ER lipid raft associated 2".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Pearce MM, Wang Y, Kelley GG, Wojcikiewicz RJ (Jul 2007). "SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells". The Journal of Biological Chemistry. 282 (28): 20104–15. doi:10.1074/jbc.M701862200. PMID 17502376.


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