E2F7

Protein-coding gene in humans
E2F7
Identifiers
AliasesE2F7, E2F transcription factor 7
External IDsOMIM: 612046; MGI: 1289147; HomoloGene: 18685; GeneCards: E2F7; OMA:E2F7 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for E2F7
Genomic location for E2F7
Band12q21.2Start77,021,248 bp[1]
End77,065,569 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for E2F7
Genomic location for E2F7
Band10 D1|10 57.74 cMStart110,581,300 bp[2]
End110,623,245 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • thymus

  • gonad

  • ganglionic eminence

  • testicle

  • secondary oocyte

  • stromal cell of endometrium

  • mucosa of ileum

  • bone marrow cells

  • pancreatic ductal cell
Top expressed in
  • otic vesicle

  • hand

  • primitive streak

  • fossa

  • tail of embryo

  • condyle

  • yolk sac

  • genital tubercle

  • abdominal wall

  • mandibular prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • transcription corepressor activity
  • protein binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • identical protein binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • transcription factor binding
  • sequence-specific DNA binding
Cellular component
  • transcription regulator complex
  • nucleus
  • nucleoplasm
  • nuclear speck
  • RNA polymerase II transcription regulator complex
Biological process
  • trophoblast giant cell differentiation
  • regulation of transcription, DNA-templated
  • chorionic trophoblast cell differentiation
  • negative regulation of transcription involved in G1/S transition of mitotic cell cycle
  • placenta development
  • DNA damage response, signal transduction by p53 class mediator
  • hepatocyte differentiation
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • cellular response to DNA damage stimulus
  • negative regulation of G1/S transition of mitotic cell cycle
  • cell cycle
  • negative regulation of cytokinesis
  • positive regulation of DNA endoreduplication
  • positive regulation of transcription by RNA polymerase II
  • sprouting angiogenesis
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • negative regulation of cell population proliferation
  • regulation of cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

144455

52679

Ensembl

ENSG00000165891

ENSMUSG00000020185

UniProt

Q96AV8

Q6S7F2

RefSeq (mRNA)

NM_203394

NM_178609
NM_001358560

RefSeq (protein)

NP_976328

NP_848724
NP_001345489

Location (UCSC)Chr 12: 77.02 – 77.07 MbChr 10: 110.58 – 110.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor E2F7 is a protein that in humans is encoded by the E2F7 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165891 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020185 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G (Oct 2003). "Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation". J Biol Chem. 278 (43): 42041–9. doi:10.1074/jbc.M308105200. PMID 12893818.
  6. ^ "Entrez Gene: E2F7 E2F transcription factor 7".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Reimer D, Sadr S, Wiedemair A, et al. (2007). "Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patients". Clin. Cancer Res. 13 (1): 144–51. doi:10.1158/1078-0432.CCR-06-0780. PMID 17200349. S2CID 23881262.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Logan N, Graham A, Zhao X, et al. (2005). "E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7". Oncogene. 24 (31): 5000–4. doi:10.1038/sj.onc.1208703. PMID 15897886. S2CID 2042011.
  • Logan N, Delavaine L, Graham A, et al. (2004). "E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains". Oncogene. 23 (30): 5138–50. doi:10.1038/sj.onc.1207649. PMID 15133492.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Di Stefano L, Jensen MR, Helin K (2004). "E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes". EMBO J. 22 (23): 6289–98. doi:10.1093/emboj/cdg613. PMC 291854. PMID 14633988.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • v
  • t
  • e