DENND4A

Protein-coding gene in the species Homo sapiens

DENND4A
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2PSN, 3B97

Identifiers
AliasesDENND4A, IRLB, MYCPBP, DENN domain containing 4A
External IDsOMIM: 600382; MGI: 2142979; HomoloGene: 55933; GeneCards: DENND4A; OMA:DENND4A - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for DENND4A
Genomic location for DENND4A
Band15q22.31Start65,658,046 bp[1]
End65,792,293 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for DENND4A
Genomic location for DENND4A
Band9|9 CStart64,718,622 bp[2]
End64,826,949 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • body of pancreas

  • testicle

  • cerebellar hemisphere

  • sural nerve

  • right hemisphere of cerebellum

  • epithelium of colon

  • right lobe of liver

  • islet of Langerhans

  • anterior pituitary
Top expressed in
  • granulocyte

  • substantia nigra

  • bone marrow

  • right lobe of liver

  • zygote

  • spleen

  • blood

  • pineal gland

  • piriform cortex

  • otolith organ
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • guanyl-nucleotide exchange factor activity
  • protein binding
Cellular component
  • nucleus
  • cytosol
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10260

102442

Ensembl

ENSG00000174485

ENSMUSG00000053641

UniProt

Q7Z401

n/a

RefSeq (mRNA)

NM_001144823
NM_005848
NM_001320835
NM_001376919
NM_001376920

NM_001162917
NM_176935

RefSeq (protein)

NP_001138295
NP_001307764
NP_005839
NP_001363848
NP_001363849

n/a

Location (UCSC)Chr 15: 65.66 – 65.79 MbChr 9: 64.72 – 64.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-myc promoter-binding protein is a protein that in humans is encoded by the DENND4A gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174485 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053641 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stasiv YZ, Mashkova TD, Chernov BK, Sokolova IV, Itkes AV, Kisselev LL (Sep 1994). "Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element". Gene. 145 (2): 267–72. doi:10.1016/0378-1119(94)90018-3. PMID 8056341.
  6. ^ Semova N, Kapanadze B, Corcoran M, Kutsenko A, Baranova A, Semov A (Aug 2003). "Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges small star, filled". Genomics. 82 (3): 343–54. doi:10.1016/S0888-7543(03)00103-4. PMID 12906859.
  7. ^ "Entrez Gene: DENND4A DENN/MADD domain containing 4A".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Uramoto H, Izumi H, Ise T, et al. (2002). "p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression". J. Biol. Chem. 277 (35): 31694–702. doi:10.1074/jbc.M200266200. PMID 12080043.


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