COG3

Protein-coding gene in the species Homo sapiens
COG3
Identifiers
AliasesCOG3, SEC34, component of oligomeric golgi complex 3
External IDsOMIM: 606975; MGI: 2450151; HomoloGene: 5854; GeneCards: COG3; OMA:COG3 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for COG3
Genomic location for COG3
Band13q14.13Start45,464,898 bp[1]
End45,536,701 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for COG3
Genomic location for COG3
Band14|14 D3Start75,939,790 bp[2]
End75,991,998 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • right lobe of liver

  • Achilles tendon

  • rectum

  • olfactory zone of nasal mucosa

  • monocyte

  • mucosa of ileum

  • granulocyte

  • pancreatic ductal cell

  • left adrenal cortex
Top expressed in
  • otolith organ

  • utricle

  • Paneth cell

  • cumulus cell

  • seminal vesicula

  • hand

  • ciliary body

  • medullary collecting duct

  • lacrimal gland

  • iris
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • Golgi membrane
  • cis-Golgi network
  • membrane
  • Golgi apparatus
  • Golgi cisterna membrane
  • Golgi transport complex
  • trans-Golgi network membrane
  • cytosol
  • plasma membrane
Biological process
  • protein glycosylation
  • intracellular protein transport
  • protein stabilization
  • intra-Golgi vesicle-mediated transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • protein transport
  • Golgi organization
  • protein localization to organelle
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

83548

338337

Ensembl

ENSG00000136152

ENSMUSG00000034893

UniProt

Q96JB2

Q8CI04

RefSeq (mRNA)

NM_001204476
NM_031431

NM_177381

RefSeq (protein)

NP_113619

n/a

Location (UCSC)Chr 13: 45.46 – 45.54 MbChr 14: 75.94 – 75.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.[5][6]

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.[6]

Interactions

COG3 has been shown to interact with COG2[7] and COG1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136152 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034893 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (April 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". The Journal of Cell Biology. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  6. ^ a b "Entrez Gene: COG3 component of oligomeric golgi complex 3".
  7. ^ a b Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Kim DW, Sacher M, Scarpa A, Quinn AM, Ferro-Novick S (October 1999). "High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking". Molecular Biology of the Cell. 10 (10): 3317–29. doi:10.1091/mbc.10.10.3317. PMC 25597. PMID 10512869.
  • VanRheenen SM, Cao X, Sapperstein SK, Chiang EC, Lupashin VV, Barlowe C, Waters MG (November 1999). "Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p". The Journal of Cell Biology. 147 (4): 729–42. doi:10.1083/jcb.147.4.729. PMC 2156162. PMID 10562277.
  • Suvorova ES, Kurten RC, Lupashin VV (June 2001). "Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery". The Journal of Biological Chemistry. 276 (25): 22810–8. doi:10.1074/jbc.M011624200. PMID 11292827.
  • Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Loh E, Hong W (June 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". The Journal of Biological Chemistry. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.


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