CBR3

Protein-coding gene in the species Homo sapiens


CBR3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2HRB

Identifiers
AliasesCBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDsOMIM: 603608; MGI: 1309992; HomoloGene: 20332; GeneCards: CBR3; OMA:CBR3 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for CBR3
Genomic location for CBR3
Band21q22.12Start36,135,079 bp[1]
End36,146,562 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for CBR3
Genomic location for CBR3
Band16 C4|16 54.58 cMStart93,480,103 bp[2]
End93,487,878 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • tendon of biceps brachii

  • olfactory zone of nasal mucosa

  • parotid gland

  • cartilage tissue

  • minor salivary glands

  • vulva

  • oral cavity

  • mucosa of pharynx

  • Achilles tendon
Top expressed in
  • epithelium of stomach

  • pyloric antrum

  • mucous cell of stomach

  • cervix

  • esophagus

  • stroma of bone marrow

  • skin of external ear

  • ankle joint

  • lip

  • dorsal striatum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • oxidoreductase activity
  • NADPH binding
  • carbonyl reductase (NADPH) activity
  • 3-keto sterol reductase activity
  • protein binding
Cellular component
  • nucleoplasm
  • extracellular space
  • cytoplasm
  • cytosol
Biological process
  • phylloquinone catabolic process
  • cognition
  • xenobiotic metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

874

109857

Ensembl

ENSG00000159231

ENSMUSG00000022947

UniProt

O75828

Q8K354

RefSeq (mRNA)

NM_001236

NM_173047

RefSeq (protein)

NP_001227

NP_766635

Location (UCSC)Chr 21: 36.14 – 36.15 MbChr 16: 93.48 – 93.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.[5][6][7]

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159231 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022947 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.
  6. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. ^ a b "Entrez Gene: CBR3 carbonyl reductase 3".

External links

Further reading

  • Wermuth B, Mäder-Heinemann G, Ernst E (1995). "Cloning and expression of carbonyl reductase from rat testis". Eur. J. Biochem. 228 (2): 473–9. doi:10.1111/j.1432-1033.1995.tb20286.x (inactive 2024-05-07). PMID 7705364.{{cite journal}}: CS1 maint: DOI inactive as of May 2024 (link)
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
  • Ismail E, Al-Mulla F, Tsuchida S, et al. (2000). "Carbonyl reductase: a novel metastasis-modulating function". Cancer Res. 60 (5): 1173–6. PMID 10728668.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Umemoto M, Yokoyama Y, Sato S, et al. (2001). "Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer". Br. J. Cancer. 85 (7): 1032–6. doi:10.1038/sj.bjc.6692034. PMC 2375107. PMID 11592776.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lakhman SS, Ghosh D, Blanco JG (2005). "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)". Drug Metab. Dispos. 33 (2): 254–7. doi:10.1124/dmd.104.002006. PMID 15537833. S2CID 18027092.
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  • 2hrb: Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+
    2hrb: Crystal Structure of human Carbonyl Reductase 3, complexed with NADP+


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