C-Myc
c-Myc | |||||||||||||||||||||||||
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識別號 | |||||||||||||||||||||||||
别名 | MYC;, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc | ||||||||||||||||||||||||
外部ID | OMIM:190080 MGI:97250 HomoloGene:31092 GeneCards:MYC | ||||||||||||||||||||||||
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物種 | 人類 | 小鼠 | |||||||||||||||||||||||
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mRNA序列 |
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蛋白序列 |
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基因位置(UCSC) | Chr 8: 127.74 – 127.74 Mb | Chr 15: 61.86 – 61.86 Mb | |||||||||||||||||||||||
PubMed查找 | [3] | [4] | |||||||||||||||||||||||
維基數據 | |||||||||||||||||||||||||
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C-Myc或Myc是编码转录因子的调节基因。这一基因编码的蛋白在细胞核内被磷酸化,有多种功能:在细胞周期进程、细胞凋亡和细胞轉化中发挥作用。[5]
相互作用
Myc可与以下蛋白质发生交互作用:
- ACTL6A[6]
- BRCA1[7][8][9][10]
- Bcl-2[11]
- Cyclin T1[12]
- CHD8[13]
- DNMT3A[14]
- EP400[15]
- GTF2I[16]
- HTATIP[17]
- let-7[18][19][20]
- MAPK1[11][21][22]
- MAPK8[23]
- MAX[24][25][26][27][28][29][30][31][32][33][34][35][36]
- MLH1[28]
- MYCBP2[37]
- MYCBP[38]
- NMI[7]
- NFYB[39]
- NFYC[40]
- P73[41]
- PCAF[42]
- PFDN5[43][44]
- RuvB-like 1[6][15]
- SAP130[42]
- SMAD2[45]
- SMAD3[45]
- SMARCA4[6][24]
- SMARCB1[27]
- SUPT3H[42]
- TIAM1[46]
- TADA2L[42]
- TAF9[42]
- TBX3[47]
- TFAP2A[48]
- TRRAP[6][25][26][42]
- WDR5[49]
- YY1[50]
- ZBTB17.[51][52]
参考文献
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000136997 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000022346 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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