YY1

Cấu trúc được biết đến

PDB

Tìm trên Human UniProt: PDBe RCSB

Danh sách mã id PDB
1UBD, 1ZNM, 4C5I

Mã định danh

Danh pháp

YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS

ID ngoài

OMIM: 600013 HomoloGene: 2556 GeneCards: YY1

Vị trí gen (Người)

NST	Nhiễm sắc thể 14 (người)^[1]

Băng	14q32.2	Bắt đầu	100,238,298 bp^[1]
Băng	14q32.2	Kết thúc	100,282,788 bp^[1]

Mẫu hình biểu hiện RNA

Thêm nguồn tham khảo về sự biểu hiện

Bản thể gen
Chức năng phân tử	• DNA binding • GO:0001106 transcription corepressor activity • GO:0001105 transcription coactivator activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • four-way junction DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • RNA binding • nucleic acid binding • SMAD binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • histone deacetylase binding
Thành phần tế bào	• Ino80 complex • nuclear matrix • nhân tế bào • Chất nhân • transcription regulator complex • tế bào chất • PcG protein complex
Quá trình sinh học	• biệt hóa tế bào • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to UV • negative regulation of gene expression • transcription, DNA-templated • cellular response to DNA damage stimulus • double-strand break repair via homologous recombination • Sự tạo tinh • GO:0100026 Sửa chữa DNA • protein deubiquitination • negative regulation of interferon-beta production • GO:1901227 negative regulation of transcription by RNA polymerase II • RNA localization • anterior/posterior pattern specification • response to UV-C • GO:1901313 positive regulation of gene expression • response to prostaglandin F • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • camera-type eye morphogenesis • GO:0051312, GO:0007083 chromosome organization • cellular response to interleukin-1 • negative regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of cell growth involved in cardiac muscle cell development
Nguồn: Amigo / QuickGO

Gen cùng nguồn

Loài

Người

Chuột

Entrez


7528


n/a

Ensembl


ENSG00000100811


n/a

UniProt


P25490


n/a

RefSeq (mRNA)


NM_003403


n/a

RefSeq (protein)


NP_003394


n/a

Vị trí gen (UCSC)

Chr 14: 100.24 – 100.28 Mb

n/a

PubMed

^[2]

n/a

Wikidata

Xem/Sửa Người

YY1 (Yin Yang 1)^[3] là một protein ở người được mã hóa bởi gen YY1.^[4]^[5]

Tương tác

YY1 đã cho thấy có tương tác với:

ATF6,^[6]
EP300,^[7]^[8]
FKBP3,^[9]
HDAC3,^[7]^[10]
Histone deacetylase 2,^[7]^[10]^[11]
Myc,^[12]
NOTCH1,^[13]
RYBP,^[14] và
SAP30.^[15]
Seryl-tRNA Synthetase.^[16]

Tham khảo

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100811 - Ensembl, May 2017
^ “Human PubMed Reference:”.
^ Thiaville MM, Kim J (2011). “Oncogenic potential of yin yang 1 mediated through control of imprinted genes”. Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
^ Shi Y, Seto E, Chang LS, Shenk T (tháng 10 năm 1991). “Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein”. Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281.
^ Zhu W, Lossie AC, Camper SA, Gumucio DL (tháng 4 năm 1994). “Chromosomal localization of the transcription factor YY1 in the mouse and human”. Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. PMID 7912122.
^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (tháng 7 năm 2000). “ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1”. Molecular and Cellular Biology. 20 (14): 5096–106. doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.
^ ^a ^b ^c Yao YL, Yang WM, Seto E (tháng 9 năm 2001). “Regulation of transcription factor YY1 by acetylation and deacetylation”. Molecular and Cellular Biology. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.
^ Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (tháng 5 năm 1995). “Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300”. Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
^ Yang WM, Yao YL, Seto E (tháng 9 năm 2001). “The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1”. The EMBO Journal. 20 (17): 4814–25. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
^ ^a ^b Yang WM, Yao YL, Sun JM, Davie JR, Seto E (tháng 10 năm 1997). “Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family”. The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (tháng 2 năm 1997). “Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1”. Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
^ Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (tháng 12 năm 1993). “Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc”. Science. 262 (5141): 1889–92. doi:10.1126/science.8266081. PMID 8266081.
^ Yeh TS, Lin YM, Hsieh RH, Tseng MJ (tháng 10 năm 2003). “Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch”. The Journal of Biological Chemistry. 278 (43): 41963–9. doi:10.1074/jbc.M304353200. PMID 12913000.
^ García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (tháng 6 năm 1999). “RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1”. The EMBO Journal. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
^ Huang NE, Lin CH, Lin YS, Yu WC (tháng 6 năm 2003). “Modulation of YY1 activity by SAP30”. Biochemical and Biophysical Research Communications. 306 (1): 267–75. doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.
^ Fu CY, Wang P, Tsai HJ (tháng 11 năm 2017). “Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis”. Nucleic Acids Research. 45 (5): 2423–2437. doi:10.1093/nar/gkw1187.

Đọc thêm

Thomas MJ, Seto E (tháng 8 năm 1999). “Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?”. Gene. 236 (2): 197–208. doi:10.1016/S0378-1119(99)00261-9. PMID 10452940.
Park K, Atchison ML (tháng 11 năm 1991). “Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site”. Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9804–8. doi:10.1073/pnas.88.21.9804. PMC 52809. PMID 1946405.
Yang WM, Inouye CJ, Seto E (tháng 6 năm 1995). “Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity”. The Journal of Biological Chemistry. 270 (25): 15187–93. doi:10.1074/jbc.270.25.15187. PMID 7541038.
Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (tháng 5 năm 1995). “Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300”. Genes & Development. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
Zhou Q, Gedrich RW, Engel DA (tháng 7 năm 1995). “Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB”. Journal of Virology. 69 (7): 4323–30. PMC 189172. PMID 7769693.
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (tháng 12 năm 1993). “Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc”. Science. 262 (5141): 1889–92. doi:10.1126/science.8266081. PMID 8266081.
Becker KG, Swergold GD, Ozato K, Thayer RE (tháng 10 năm 1993). “Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element”. Human Molecular Genetics. 2 (10): 1697–702. doi:10.1093/hmg/2.10.1697. PMID 8268924.
Margolis DM, Somasundaran M, Green MR (tháng 2 năm 1994). “Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production”. Journal of Virology. 68 (2): 905–10. PMC 236527. PMID 8289393.
Lee JS, Galvin KM, Shi Y (tháng 7 năm 1993). “Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1”. Proceedings of the National Academy of Sciences of the United States of America. 90 (13): 6145–9. doi:10.1073/pnas.90.13.6145. PMC 46884. PMID 8327494.
Yang WM, Inouye C, Zeng Y, Bearss D, Seto E (tháng 11 năm 1996). “Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3”. Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12845–50. doi:10.1073/pnas.93.23.12845. PMC 24008. PMID 8917507.
Houbaviy HB, Usheva A, Shenk T, Burley SK (tháng 11 năm 1996). “Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator”. Proceedings of the National Academy of Sciences of the United States of America. 93 (24): 13577–82. doi:10.1073/pnas.93.24.13577. PMC 19349. PMID 8942976.
Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (tháng 2 năm 1997). “Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1”. Nucleic Acids Research. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
Cole EG, Gaston K (tháng 9 năm 1997). “A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors”. Nucleic Acids Research. 25 (18): 3705–11. doi:10.1093/nar/25.18.3705. PMC 146936. PMID 9278494.
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (tháng 10 năm 1997). “Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family”. The Journal of Biological Chemistry. 272 (44): 28001–7. doi:10.1074/jbc.272.44.28001. PMID 9346952.
Romerio F, Gabriel MN, Margolis DM (tháng 12 năm 1997). “Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF”. Journal of Virology. 71 (12): 9375–82. PMC 230241. PMID 9371597.
McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS (tháng 3 năm 1998). “Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking”. Journal of Cellular Biochemistry. 68 (4): 500–10. doi:10.1002/(SICI)1097-4644(19980315)68:4<500::AID-JCB9>3.0.CO;2-U. PMID 9493912.
Viles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM (tháng 6 năm 1998). “Design, synthesis and structure of a zinc finger with an artificial beta-turn”. Journal of Molecular Biology. 279 (4): 973–86. doi:10.1006/jmbi.1998.1764. PMID 9642075.
Yao YL, Dupont BR, Ghosh S, Fang Y, Leach RJ, Seto E (tháng 8 năm 1998). “Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1”. Nucleic Acids Research. 26 (16): 3776–83. doi:10.1093/nar/26.16.3776. PMC 147783. PMID 9685495.