SMO |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4JKV, 4N4W, 4O9R, 4QIM, 4QIN, 5L7I | | |
Ідентифікатори |
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Символи | SMO, FZD11, Gx, SMOH, smoothened, frizzled class receptor, CRJS, PHLS |
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Зовнішні ІД | OMIM: 601500 MGI: 108075 HomoloGene: 4115 GeneCards: SMO |
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Пов'язані генетичні захворювання |
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Curry-Jones syndrome[1] |
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Реагує на сполуку |
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saridegib, sonidegib, vismodegib, saridegib, vismodegib, sonidegib, BMS-833923, glasdegib, TAK-441[2] |
Онтологія гена |
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Молекулярна функція | • patched binding • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity • signal transducer activity • G protein-coupled receptor activity • Wnt-protein binding • Wnt-activated receptor activity |
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Клітинна компонента | • цитоплазма • endocytic vesicle membrane • мембрана • caveola • cell projection • екзосома • комплекс Ґольджі • внутрішньоклітинна мембранна органела • клітинна мембрана • ciliary tip • ciliary membrane • війка • integral component of membrane |
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Біологічний процес | • pattern specification process • pancreas morphogenesis • negative regulation of DNA binding • smoothened signaling pathway involved in ventral spinal cord patterning • васкулогенез • heart looping • odontogenesis of dentin-containing tooth • atrial septum morphogenesis • cell surface receptor signaling pathway • positive regulation of mesenchymal cell proliferation • cerebellar cortex morphogenesis • positive regulation of multicellular organism growth • hair follicle morphogenesis • regulation of heart morphogenesis • type B pancreatic cell development • positive regulation of neuroblast proliferation • renal system development • positive regulation of branching involved in ureteric bud morphogenesis • positive regulation of smoothened signaling pathway • осифікація • embryonic organ development • dentate gyrus development • epithelial-mesenchymal cell signaling • regulation of stem cell population maintenance • in utero embryonic development • cellular response to cholesterol • negative regulation of gene expression • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • forebrain morphogenesis • negative regulation of hair follicle development • central nervous system development • central nervous system neuron differentiation • positive regulation of protein import into nucleus • smoothened signaling pathway • G protein-coupled receptor signaling pathway • multicellular organism growth • thalamus development • positive regulation of epithelial cell proliferation • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation • cell fate specification • protein stabilization • positive regulation of organ growth • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • developmental growth • osteoblast differentiation • determination of left/right asymmetry in lateral mesoderm • cerebral cortex development • регуляція експресії генів • homeostasis of number of cells within a tissue • dorsal/ventral neural tube patterning • GO:0045996 negative regulation of transcription, DNA-templated • dorsal/ventral pattern formation • myoblast migration • positive regulation of hh target transcription factor activity • ventral midline determination • розвиток клітин • astrocyte activation • heart morphogenesis • mesenchymal to epithelial transition involved in metanephric renal vesicle formation • somite development • mammary gland epithelial cell differentiation • multicellular organism development • GO:1901313 positive regulation of gene expression • determination of left/right symmetry • skeletal muscle fiber development • neural crest cell migration • positive regulation of cell population proliferation • protein localization to nucleus • digestive tract development • negative regulation of epithelial cell differentiation • left/right axis specification • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 сигнальна трансдукція • midgut development • non-canonical Wnt signaling pathway • canonical Wnt signaling pathway |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/e/e2/PBB_GE_SMO_218629_at_fs.png/250px-PBB_GE_SMO_218629_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 7: 129.19 – 129.21 Mb | Хр. 6: 29.74 – 29.76 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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