PTGS2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 5F1A, 5F19, 5IKQ, 5IKT, 5IKV, 5IKR | | |
Ідентифікатори |
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Символи | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2 |
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Зовнішні ІД | OMIM: 600262 MGI: 97798 HomoloGene: 31000 GeneCards: PTGS2 |
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шифр КФ | 1.14.99.1 |
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Реагує на сполуку |
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ацетилсаліцилова кислота, benzquinamide, carprofen, целекоксиб, диклофенак, етодолак, Еторикоксиб, флурбіпрофен, ібупрофен, кетопрофен, кеторолак, lumiracoxib, meclofenamic acid, мефенамінова кислота, мелоксикам, напроксен, німесулід, NS-398, oxaprozin, парацетамол, фенілбутазон, піроксикам, Резвератрол, рофекоксиб, suprofen, valdecoxib, напроксен, diclofenac sodium, iguratimod, oxaprozin, apricoxib, ацетилсаліцилова кислота, ібупрофен, polmacoxib, кеторолак, isoxicam, диклофенак, етодолак, bromfenac, (RS)-fenoprofen, діфлунізал, esflurbiprofen, diclofenac potassium, (RS)-fenoprofen calcium dihydrate, ketorolac tromethamine, naproxen sodium, tolmetin sodium[1] |
Онтологія гена |
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Молекулярна функція | • arachidonate 15-lipoxygenase activity • зв'язування з іоном металу • heme binding • enzyme binding • oxidoreductase activity • protein homodimerization activity • dioxygenase activity • GO:0001948, GO:0016582 protein binding • peroxidase activity • prostaglandin-endoperoxide synthase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • transferase activity |
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Клітинна компонента | • цитоплазма • endoplasmic reticulum lumen • мембрана • caveola • neuron projection • organelle membrane • ендоплазматичний ретикулум • внутрішньоклітинна мембранна органела • endoplasmic reticulum membrane • GO:0009327 protein-containing complex |
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Біологічний процес | • response to fructose • навчення • response to organic substance • lipoxygenase pathway • cellular response to mechanical stimulus • response to manganese ion • Ангіогенез • cellular response to hypoxia • embryo implantation • negative regulation of cell population proliferation • response to cytokine • negative regulation of smooth muscle contraction • пам'ять • GO:0001306 response to oxidative stress • maintenance of blood-brain barrier • response to lithium ion • response to tumor necrosis factor • fatty acid biosynthetic process • positive regulation of synaptic transmission, glutamatergic • positive regulation of vasoconstriction • response to organonitrogen compound • inflammatory response • positive regulation of smooth muscle contraction • bone mineralization • response to fatty acid • response to vitamin D • cellular response to UV • positive regulation of fever generation • cellular response to fluid shear stress • positive regulation of synaptic plasticity • regulation of blood pressure • response to lipopolysaccharide • positive regulation of platelet-derived growth factor production • regulation of inflammatory response • brown fat cell differentiation • sensory perception of pain • response to radiation • prostaglandin biosynthetic process • cellular response to ATP • овуляція • positive regulation of smooth muscle cell proliferation • hair cycle • response to estradiol • positive regulation of cell death • positive regulation of cell migration involved in sprouting angiogenesis • GO:1904578 response to organic cyclic compound • lipid metabolism • positive regulation of nitric oxide biosynthetic process • response to glucocorticoid • cyclooxygenase pathway • fatty acid metabolic process • positive regulation of fibroblast growth factor production • decidualization • regulation of cell population proliferation • positive regulation of cell population proliferation • negative regulation of calcium ion transport • positive regulation of apoptotic process • positive regulation of transforming growth factor beta production • positive regulation of vascular endothelial growth factor production • positive regulation of brown fat cell differentiation • negative regulation of synaptic transmission, dopaminergic • cellular oxidant detoxification • GO:0010260 старіння людини • NAD biosynthesis via nicotinamide riboside salvage pathway • cellular response to heat • positive regulation of prostaglandin biosynthetic process • positive regulation of peptidyl-serine phosphorylation • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular response to non-ionic osmotic stress • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • cellular response to lead ion • response to angiotensin • prostaglandin metabolic process • positive regulation of protein import into nucleus • cytokine-mediated signaling pathway • long-chain fatty acid biosynthetic process • negative regulation of cell cycle • regulation of neuroinflammatory response |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 1: 186.67 – 186.68 Mb | Хр. 1: 149.98 – 149.98 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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