MUC16 |
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Ідентифікатори |
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Символи | MUC16, CA125, mucin 16, cell surface associated |
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Зовнішні ІД | OMIM: 606154 HomoloGene: 133291 GeneCards: MUC16 |
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Онтологія гена |
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Молекулярна функція | • GO:0001948, GO:0016582 protein binding |
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Клітинна компонента | • Golgi lumen • integral component of membrane • extracellular region • везикула • екзосома • мембрана • extrinsic component of membrane • міжклітинний простір • клітинна мембрана |
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Біологічний процес | • адгезія клітин • O-glycan processing • stimulatory C-type lectin receptor signaling pathway |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 19: 8.85 – 8.98 Mb | н/д |
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PubMed search | [1] | н/д |
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Вікідані |
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Муцин-16 (англ. Mucin 16, cell surface associated) – білок, який кодується геном MUC16, розташованим у людини на короткому плечі 19-ї хромосоми.[2] Довжина поліпептидного ланцюга білка становить 14 507 амінокислот, а молекулярна маса — 1 519 175[3].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MLKPSGLPGS | | SSPTRSLMTG | | SRSTKATPEM | | DSGLTGATLS | | PKTSTGAIVV |
TEHTLPFTSP | | DKTLASPTSS | | VVGRTTQSLG | | VMSSALPEST | | SRGMTHSEQR |
TSPSLSPQVN | | GTPSRNYPAT | | SMVSGLSSPR | | TRTSSTEGNF | | TKEASTYTLT |
VETTSGPVTE | | KYTVPTETST | | TEGDSTETPW | | DTRYIPVKIT | | SPMKTFADST |
ASKENAPVSM | | TPAETTVTDS | | HTPGRTNPSF | | GTLYSSFLDL | | SPKGTPNSRG |
ETSLELILST | | TGYPFSSPEP | | GSAGHSRIST | | SAPLSSSASV | | LDNKISETSI |
FSGQSLTSPL | | SPGVPEARAS | | TMPNSAIPFS | | MTLSNAETSA | | ERVRSTISSL |
GTPSISTKQT | | AETILTFHAF | | AETMDIPSTH | | IAKTLASEWL | | GSPGTLGGTS |
TSALTTTSPS | | TTLVSEETNT | | HHSTSGKETE | | GTLNTSMTPL | | ETSAPGEESE |
MTATLVPTLG | | FTTLDSKIRS | | PSQVSSSHPT | | RELRTTGSTS | | GRQSSSTAAH |
GSSDILRATT | | SSTSKASSWT | | SESTAQQFSE | | PQHTQWVETS | | PSMKTERPPA |
STSVAAPITT | | SVPSVVSGFT | | TLKTSSTKGI | | WLEETSADTL | | IGESTAGPTT |
HQFAVPTGIS | | MTGGSSTRGS | | QGTTHLLTRA | | TASSETSADL | | TLATNGVPVS |
VSPAVSKTAA | | GSSPPGGTKP | | SYTMVSSVIP | | ETSSLQSSAF | | REGTSLGLTP |
LNTRHPFSSP | | EPDSAGHTKI | | STSIPLLSSA | | SVLEDKVSAT | | STFSHHKATS |
SITTGTPEIS | | TKTKPSSAVL | | SSMTLSNAAT | | SPERVRNATS | | PLTHPSPSGE |
ETAGSVLTLS | | TSAETTDSPN | | IHPTGTLTSE | | SSESPSTLSL | | PSVSGVKTTF |
SSSTPSTHLF | | TSGEETEETS | | NPSVSQPETS | | VSRVRTTLAS | | TSVPTPVFPT |
MDTWPTRSAQ | | FSSSHLVSEL | | RATSSTSVTN | | STGSALPKIS | | HLTGTATMSQ |
TNRDTFNDSA | | APQSTTWPET | | SPRFKTGLPS | | ATTTVSTSAT | | SLSATVMVSK |
FTSPATSSME | | ATSIREPSTT | | ILTTETTNGP | | GSMAVASTNI | | PIGKGYITEG |
RLDTSHLPIG | | TTASSETSMD | | FTMAKESVSM | | SVSPSQSMDA | | AGSSTPGRTS |
QFVDTFSDDV | | YHLTSREITI | | PRDGTSSALT | | PQMTATHPPS | | PDPGSARSTW |
LGILSSSPSS | | PTPKVTMSST | | FSTQRVTTSM | | IMDTVETSRW | | NMPNLPSTTS |
LTPSNIPTSG | | AIGKSTLVPL | | DTPSPATSLE | | ASEGGLPTLS | | TYPESTNTPS |
IHLGAHASSE | | SPSTIKLTMA | | SVVKPGSYTP | | LTFPSIETHI | | HVSTARMAYS |
SGSSPEMTAP | | GETNTGSTWD | | PTTYITTTDP | | KDTSSAQVST | | PHSVRTLRTT |
ENHPKTESAT | | PAAYSGSPKI | | SSSPNLTSPA | | TKAWTITDTT | | EHSTQLHYTK |
LAEKSSGFET | | QSAPGPVSVV | | IPTSPTIGSS | | TLELTSDVPG | | EPLVLAPSEQ |
TTITLPMATW | | LSTSLTEEMA | | STDLDISSPS | | SPMSTFAIFP | | PMSTPSHELS |
KSEADTSAIR | | NTDSTTLDQH | | LGIRSLGRTG | | DLTTVPITPL | | TTTWTSVIEH |
STQAQDTLSA | | TMSPTHVTQS | | LKDQTSIPAS | | ASPSHLTEVY | | PELGTQGRSS |
SEATTFWKPS | | TDTLSREIET | | GPTNIQSTPP | | MDNTTTGSSS | | SGVTLGIAHL |
PIGTSSPAET | | STNMALERRS | | STATVSMAGT | | MGLLVTSAPG | | RSISQSLGRV |
SSVLSESTTE | | GVTDSSKGSS | | PRLNTQGNTA | | LSSSLEPSYA | | EGSQMSTSIP |
LTSSPTTPDV | | EFIGGSTFWT | | KEVTTVMTSD | | ISKSSARTES | | SSATLMSTAL |
GSTENTGKEK | | LRTASMDLPS | | PTPSMEVTPW | | ISLTLSNAPN | | TTDSLDLSHG |
VHTSSAGTLA | | TDRSLNTGVT | | RASRLENGSD | | TSSKSLSMGN | | STHTSMTYTE |
KSEVSSSIHP | | RPETSAPGAE | | TTLTSTPGNR | | AISLTLPFSS | | IPVEEVISTG |
ITSGPDINSA | | PMTHSPITPP | | TIVWTSTGTI | | EQSTQPLHAV | | SSEKVSVQTQ |
STPYVNSVAV | | SASPTHENSV | | SSGSSTSSPY | | SSASLESLDS | | TISRRNAITS |
WLWDLTTSLP | | TTTWPSTSLS | | EALSSGHSGV | | SNPSSTTTEF | | PLFSAASTSA |
AKQRNPETET | | HGPQNTAAST | | LNTDASSVTG | | LSETPVGASI | | SSEVPLPMAI |
TSRSDVSGLT | | SESTANPSLG | | TASSAGTKLT | | RTISLPTSES | | LVSFRMNKDP |
WTVSIPLGSH | | PTTNTETSIP | | VNSAGPPGLS | | TVASDVIDTP | | SDGAESIPTV |
SFSPSPDTEV | | TTISHFPEKT | | THSFRTISSL | | THELTSRVTP | | IPGDWMSSAM |
STKPTGASPS | | ITLGERRTIT | | SAAPTTSPIV | | LTASFTETST | | VSLDNETTVK |
TSDILDARKT | | NELPSDSSSS | | SDLINTSIAS | | STMDVTKTAS | | ISPTSISGMT |
ASSSPSLFSS | | DRPQVPTSTT | | ETNTATSPSV | | SSNTYSLDGG | | SNVGGTPSTL |
PPFTITHPVE | | TSSALLAWSR | | PVRTFSTMVS | | TDTASGENPT | | SSNSVVTSVP |
APGTWTSVGS | | TTDLPAMGFL | | KTSPAGEAHS | | LLASTIEPAT | | AFTPHLSAAV |
VTGSSATSEA | | SLLTTSESKA | | IHSSPQTPTT | | PTSGANWETS | | ATPESLLVVT |
ETSDTTLTSK | | ILVTDTILFS | | TVSTPPSKFP | | STGTLSGASF | | PTLLPDTPAI |
PLTATEPTSS | | LATSFDSTPL | | VTIASDSLGT | | VPETTLTMSE | | TSNGDALVLK |
TVSNPDRSIP | | GITIQGVTES | | PLHPSSTSPS | | KIVAPRNTTY | | EGSITVALST |
LPAGTTGSLV | | FSQSSENSET | | TALVDSSAGL | | ERASVMPLTT | | GSQGMASSGG |
IRSGSTHSTG | | TKTFSSLPLT | | MNPGEVTAMS | | EITTNRLTAT | | QSTAPKGIPV |
KPTSAESGLL | | TPVSASSSPS | | KAFASLTTAP | | PTWGIPQSTL | | TFEFSEVPSL |
DTKSASLPTP | | GQSLNTIPDS | | DASTASSSLS | | KSPEKNPRAR | | MMTSTKAISA |
SSFQSTGFTE | | TPEGSASPSM | | AGHEPRVPTS | | GTGDPRYASE | | SMSYPDPSKA |
SSAMTSTSLA | | SKLTTLFSTG | | QAARSGSSSS | | PISLSTEKET | | SFLSPTASTS |
RKTSLFLGPS | | MARQPNILVH | | LQTSALTLSP | | TSTLNMSQEE | | PPELTSSQTI |
AEEEGTTAET | | QTLTFTPSET | | PTSLLPVSSP | | TEPTARRKSS | | PETWASSISV |
PAKTSLVETT | | DGTLVTTIKM | | SSQAAQGNST | | WPAPAEETGS | | SPAGTSPGSP |
EMSTTLKIMS | | SKEPSISPEI | | RSTVRNSPWK | | TPETTVPMET | | TVEPVTLQST |
ALGSGSTSIS | | HLPTGTTSPT | | KSPTENMLAT | | ERVSLSPSPP | | EAWTNLYSGT |
PGGTRQSLAT | | MSSVSLESPT | | ARSITGTGQQ | | SSPELVSKTT | | GMEFSMWHGS |
TGGTTGDTHV | | SLSTSSNILE | | DPVTSPNSVS | | SLTDKSKHKT | | ETWVSTTAIP |
STVLNNKIMA | | AEQQTSRSVD | | EAYSSTSSWS | | DQTSGSDITL | | GASPDVTNTL |
YITSTAQTTS | | LVSLPSGDQG | | ITSLTNPSGG | | KTSSASSVTS | | PSIGLETLRA |
NVSAVKSDIA | | PTAGHLSQTS | | SPAEVSILDV | | TTAPTPGIST | | TITTMGTNSI |
STTTPNPEVG | | MSTMDSTPAT | | ERRTTSTEHP | | STWSSTAASD | | SWTVTDMTSN |
LKVARSPGTI | | STMHTTSFLA | | SSTELDSMST | | PHGRITVIGT | | SLVTPSSDAS |
AVKTETSTSE | | RTLSPSDTTA | | STPISTFSRV | | QRMSISVPDI | | LSTSWTPSST |
EAEDVPVSMV | | STDHASTKTD | | PNTPLSTFLF | | DSLSTLDWDT | | GRSLSSATAT |
TSAPQGATTP | | QELTLETMIS | | PATSQLPFSI | | GHITSAVTPA | | AMARSSGVTF |
SRPDPTSKKA | | EQTSTQLPTT | | TSAHPGQVPR | | SAATTLDVIP | | HTAKTPDATF |
QRQGQTALTT | | EARATSDSWN | | EKEKSTPSAP | | WITEMMNSVS | | EDTIKEVTSS |
SSVLRTLNTL | | DINLESGTTS | | SPSWKSSPYE | | RIAPSESTTD | | KEAIHPSTNT |
VETTGWVTSS | | EHASHSTIPA | | HSASSKLTSP | | VVTTSTREQA | | IVSMSTTTWP |
ESTRARTEPN | | SFLTIELRDV | | SPYMDTSSTT | | QTSIISSPGS | | TAITKGPRTE |
ITSSKRISSS | | FLAQSMRSSD | | SPSEAITRLS | | NFPAMTESGG | | MILAMQTSPP |
GATSLSAPTL | | DTSATASWTG | | TPLATTQRFT | | YSEKTTLFSK | | GPEDTSQPSP |
PSVEETSSSS | | SLVPIHATTS | | PSNILLTSQG | | HSPSSTPPVT | | SVFLSETSGL |
GKTTDMSRIS | | LEPGTSLPPN | | LSSTAGEALS | | TYEASRDTKA | | IHHSADTAVT |
NMEATSSEYS | | PIPGHTKPSK | | ATSPLVTSHI | | MGDITSSTSV | | FGSSETTEIE |
TVSSVNQGLQ | | ERSTSQVASS | | ATETSTVITH | | VSSGDATTHV | | TKTQATFSSG |
TSISSPHQFI | | TSTNTFTDVS | | TNPSTSLIMT | | ESSGVTITTQ | | TGPTGAATQG |
PYLLDTSTMP | | YLTETPLAVT | | PDFMQSEKTT | | LISKGPKDVS | | WTSPPSVAET |
SYPSSLTPFL | | VTTIPPATST | | LQGQHTSSPV | | SATSVLTSGL | | VKTTDMLNTS |
MEPVTNSPQN | | LNNPSNEILA | | TLAATTDIET | | IHPSINKAVT | | NMGTASSAHV |
LHSTLPVSSE | | PSTATSPMVP | | ASSMGDALAS | | ISIPGSETTD | | IEGEPTSSLT |
AGRKENSTLQ | | EMNSTTESNI | | ILSNVSVGAI | | TEATKMEVPS | | FDATFIPTPA |
QSTKFPDIFS | | VASSRLSNSP | | PMTISTHMTT | | TQTGSSGATS | | KIPLALDTST |
LETSAGTPSV | | VTEGFAHSKI | | TTAMNNDVKD | | VSQTNPPFQD | | EASSPSSQAP |
VLVTTLPSSV | | AFTPQWHSTS | | SPVSMSSVLT | | SSLVKTAGKV | | DTSLETVTSS |
PQSMSNTLDD | | ISVTSAATTD | | IETTHPSINT | | VVTNVGTTGS | | AFESHSTVSA |
YPEPSKVTSP | | NVTTSTMEDT | | TISRSIPKSS | | KTTRTETETT | | SSLTPKLRET |
SISQEITSST | | ETSTVPYKEL | | TGATTEVSRT | | DVTSSSSTSF | | PGPDQSTVSL |
DISTETNTRL | | STSPIMTESA | | EITITTQTGP | | HGATSQDTFT | | MDPSNTTPQA |
GIHSAMTHGF | | SQLDVTTLMS | | RIPQDVSWTS | | PPSVDKTSSP | | SSFLSSPAMT |
TPSLISSTLP | | EDKLSSPMTS | | LLTSGLVKIT | | DILRTRLEPV | | TSSLPNFSST |
SDKILATSKD | | SKDTKEIFPS | | INTEETNVKA | | NNSGHESHSP | | ALADSETPKA |
TTQMVITTTV | | GDPAPSTSMP | | VHGSSETTNI | | KREPTYFLTP | | RLRETSTSQE |
SSFPTDTSFL | | LSKVPTGTIT | | EVSSTGVNSS | | SKISTPDHDK | | STVPPDTFTG |
EIPRVFTSSI | | KTKSAEMTIT | | TQASPPESAS | | HSTLPLDTST | | TLSQGGTHST |
VTQGFPYSEV | | TTLMGMGPGN | | VSWMTTPPVE | | ETSSVSSLMS | | SPAMTSPSPV |
SSTSPQSIPS | | SPLPVTALPT | | SVLVTTTDVL | | GTTSPESVTS | | SPPNLSSITH |
ERPATYKDTA | | HTEAAMHHST | | NTAVTNVGTS | | GSGHKSQSSV | | LADSETSKAT |
PLMSTTSTLG | | DTSVSTSTPN | | ISQTNQIQTE | | PTASLSPRLR | | ESSTSEKTSS |
TTETNTAFSY | | VPTGAITQAS | | RTEISSSRTS | | ISDLDRPTIA | | PDISTGMITR |
LFTSPIMTKS | | AEMTVTTQTT | | TPGATSQGIL | | PWDTSTTLFQ | | GGTHSTVSQG |
FPHSEITTLR | | SRTPGDVSWM | | TTPPVEETSS | | GFSLMSPSMT | | SPSPVSSTSP |
ESIPSSPLPV | | TALLTSVLVT | | TTNVLGTTSP | | EPVTSSPPNL | | SSPTQERLTT |
YKDTAHTEAM | | HASMHTNTAV | | ANVGTSISGH | | ESQSSVPADS | | HTSKATSPMG |
ITFAMGDTSV | | STSTPAFFET | | RIQTESTSSL | | IPGLRDTRTS | | EEINTVTETS |
TVLSEVPTTT | | TTEVSRTEVI | | TSSRTTISGP | | DHSKMSPYIS | | TETITRLSTF |
PFVTGSTEMA | | ITNQTGPIGT | | ISQATLTLDT | | SSTASWEGTH | | SPVTQRFPHS |
EETTTMSRST | | KGVSWQSPPS | | VEETSSPSSP | | VPLPAITSHS | | SLYSAVSGSS |
PTSALPVTSL | | LTSGRRKTID | | MLDTHSELVT | | SSLPSASSFS | | GEILTSEAST |
NTETIHFSEN | | TAETNMGTTN | | SMHKLHSSVS | | IHSQPSGHTP | | PKVTGSMMED |
AIVSTSTPGS | | PETKNVDRDS | | TSPLTPELKE | | DSTALVMNST | | TESNTVFSSV |
SLDAATEVSR | | AEVTYYDPTF | | MPASAQSTKS | | PDISPEASSS | | HSNSPPLTIS |
THKTIATQTG | | PSGVTSLGQL | | TLDTSTIATS | | AGTPSARTQD | | FVDSETTSVM |
NNDLNDVLKT | | SPFSAEEANS | | LSSQAPLLVT | | TSPSPVTSTL | | QEHSTSSLVS |
VTSVPTPTLA | | KITDMDTNLE | | PVTRSPQNLR | | NTLATSEATT | | DTHTMHPSIN |
TAVANVGTTS | | SPNEFYFTVS | | PDSDPYKATS | | AVVITSTSGD | | SIVSTSMPRS |
SAMKKIESET | | TFSLIFRLRE | | TSTSQKIGSS | | SDTSTVFDKA | | FTAATTEVSR |
TELTSSSRTS | | IQGTEKPTMS | | PDTSTRSVTM | | LSTFAGLTKS | | EERTIATQTG |
PHRATSQGTL | | TWDTSITTSQ | | AGTHSAMTHG | | FSQLDLSTLT | | SRVPEYISGT |
SPPSVEKTSS | | SSSLLSLPAI | | TSPSPVPTTL | | PESRPSSPVH | | LTSLPTSGLV |
KTTDMLASVA | | SLPPNLGSTS | | HKIPTTSEDI | | KDTEKMYPST | | NIAVTNVGTT |
TSEKESYSSV | | PAYSEPPKVT | | SPMVTSFNIR | | DTIVSTSMPG | | SSEITRIEME |
STFSLAHGLK | | GTSTSQDPIV | | STEKSAVLHK | | LTTGATETSR | | TEVASSRRTS |
IPGPDHSTES | | PDISTEVIPS | | LPISLGITES | | SNMTIITRTG | | PPLGSTSQGT |
FTLDTPTTSS | | RAGTHSMATQ | | EFPHSEMTTV | | MNKDPEILSW | | TIPPSIEKTS |
FSSSLMPSPA | | MTSPPVSSTL | | PKTIHTTPSP | | MTSLLTPSLV | | MTTDTLGTSP |
EPTTSSPPNL | | SSTSHEILTT | | DEDTTAIEAM | | HPSTSTAATN | | VETTSSGHGS |
QSSVLADSEK | | TKATAPMDTT | | STMGHTTVST | | SMSVSSETTK | | IKRESTYSLT |
PGLRETSISQ | | NASFSTDTSI | | VLSEVPTGTT | | AEVSRTEVTS | | SGRTSIPGPS |
QSTVLPEIST | | RTMTRLFASP | | TMTESAEMTI | | PTQTGPSGST | | SQDTLTLDTS |
TTKSQAKTHS | | TLTQRFPHSE | | MTTLMSRGPG | | DMSWQSSPSL | | ENPSSLPSLL |
SLPATTSPPP | | ISSTLPVTIS | | SSPLPVTSLL | | TSSPVTTTDM | | LHTSPELVTS |
SPPKLSHTSD | | ERLTTGKDTT | | NTEAVHPSTN | | TAASNVEIPS | | SGHESPSSAL |
ADSETSKATS | | PMFITSTQED | | TTVAISTPHF | | LETSRIQKES | | ISSLSPKLRE |
TGSSVETSSA | | IETSAVLSEV | | SIGATTEISR | | TEVTSSSRTS | | ISGSAESTML |
PEISTTRKII | | KFPTSPILAE | | SSEMTIKTQT | | SPPGSTSEST | | FTLDTSTTPS |
LVITHSTMTQ | | RLPHSEITTL | | VSRGAGDVPR | | PSSLPVEETS | | PPSSQLSLSA |
MISPSPVSST | | LPASSHSSSA | | SVTSLLTPGQ | | VKTTEVLDAS | | AEPETSSPPS |
LSSTSVEILA | | TSEVTTDTEK | | IHPFSNTAVT | | KVGTSSSGHE | | SPSSVLPDSE |
TTKATSAMGT | | ISIMGDTSVS | | TLTPALSNTR | | KIQSEPASSL | | TTRLRETSTS |
EETSLATEAN | | TVLSKVSTGA | | TTEVSRTEAI | | SFSRTSMSGP | | EQSTMSQDIS |
IGTIPRISAS | | SVLTESAKMT | | ITTQTGPSES | | TLESTLNLNT | | ATTPSWVETH |
SIVIQGFPHP | | EMTTSMGRGP | | GGVSWPSPPF | | VKETSPPSSP | | LSLPAVTSPH |
PVSTTFLAHI | | PPSPLPVTSL | | LTSGPATTTD | | ILGTSTEPGT | | SSSSSLSTTS |
HERLTTYKDT | | AHTEAVHPST | | NTGGTNVATT | | SSGYKSQSSV | | LADSSPMCTT |
STMGDTSVLT | | STPAFLETRR | | IQTELASSLT | | PGLRESSGSE | | GTSSGTKMST |
VLSKVPTGAT | | TEISKEDVTS | | IPGPAQSTIS | | PDISTRTVSW | | FSTSPVMTES |
AEITMNTHTS | | PLGATTQGTS | | TLDTSSTTSL | | TMTHSTISQG | | FSHSQMSTLM |
RRGPEDVSWM | | SPPLLEKTRP | | SFSLMSSPAT | | TSPSPVSSTL | | PESISSSPLP |
VTSLLTSGLA | | KTTDMLHKSS | | EPVTNSPANL | | SSTSVEILAT | | SEVTTDTEKT |
HPSSNRTVTD | | VGTSSSGHES | | TSFVLADSQT | | SKVTSPMVIT | | STMEDTSVST |
STPGFFETSR | | IQTEPTSSLT | | LGLRKTSSSE | | GTSLATEMST | | VLSGVPTGAT |
AEVSRTEVTS | | SSRTSISGFA | | QLTVSPETST | | ETITRLPTSS | | IMTESAEMMI |
KTQTDPPGST | | PESTHTVDIS | | TTPNWVETHS | | TVTQRFSHSE | | MTTLVSRSPG |
DMLWPSQSSV | | EETSSASSLL | | SLPATTSPSP | | VSSTLVEDFP | | SASLPVTSLL |
NPGLVITTDR | | MGISREPGTS | | STSNLSSTSH | | ERLTTLEDTV | | DTEDMQPSTH |
TAVTNVRTSI | | SGHESQSSVL | | SDSETPKATS | | PMGTTYTMGE | | TSVSISTSDF |
FETSRIQIEP | | TSSLTSGLRE | | TSSSERISSA | | TEGSTVLSEV | | PSGATTEVSR |
TEVISSRGTS | | MSGPDQFTIS | | PDISTEAITR | | LSTSPIMTES | | AESAITIETG |
SPGATSEGTL | | TLDTSTTTFW | | SGTHSTASPG | | FSHSEMTTLM | | SRTPGDVPWP |
SLPSVEEASS | | VSSSLSSPAM | | TSTSFFSTLP | | ESISSSPHPV | | TALLTLGPVK |
TTDMLRTSSE | | PETSSPPNLS | | STSAEILATS | | EVTKDREKIH | | PSSNTPVVNV |
GTVIYKHLSP | | SSVLADLVTT | | KPTSPMATTS | | TLGNTSVSTS | | TPAFPETMMT |
QPTSSLTSGL | | REISTSQETS | | SATERSASLS | | GMPTGATTKV | | SRTEALSLGR |
TSTPGPAQST | | ISPEISTETI | | TRISTPLTTT | | GSAEMTITPK | | TGHSGASSQG |
TFTLDTSSRA | | SWPGTHSAAT | | HRSPHSGMTT | | PMSRGPEDVS | | WPSRPSVEKT |
SPPSSLVSLS | | AVTSPSPLYS | | TPSESSHSSP | | LRVTSLFTPV | | MMKTTDMLDT |
SLEPVTTSPP | | SMNITSDESL | | ATSKATMETE | | AIQLSENTAV | | TQMGTISARQ |
EFYSSYPGLP | | EPSKVTSPVV | | TSSTIKDIVS | | TTIPASSEIT | | RIEMESTSTL |
TPTPRETSTS | | QEIHSATKPS | | TVPYKALTSA | | TIEDSMTQVM | | SSSRGPSPDQ |
STMSQDISTE | | VITRLSTSPI | | KTESTEMTIT | | TQTGSPGATS | | RGTLTLDTST |
TFMSGTHSTA | | SQGFSHSQMT | | ALMSRTPGDV | | PWLSHPSVEE | | ASSASFSLSS |
PVMTSSSPVS | | STLPDSIHSS | | SLPVTSLLTS | | GLVKTTELLG | | TSSEPETSSP |
PNLSSTSAEI | | LAITEVTTDT | | EKLEMTNVVT | | SGYTHESPSS | | VLADSVTTKA |
TSSMGITYPT | | GDTNVLTSTP | | AFSDTSRIQT | | KSKLSLTPGL | | METSISEETS |
SATEKSTVLS | | SVPTGATTEV | | SRTEAISSSR | | TSIPGPAQST | | MSSDTSMETI |
TRISTPLTRK | | ESTDMAITPK | | TGPSGATSQG | | TFTLDSSSTA | | SWPGTHSATT |
QRFPQSVVTT | | PMSRGPEDVS | | WPSPLSVEKN | | SPPSSLVSSS | | SVTSPSPLYS |
TPSGSSHSSP | | VPVTSLFTSI | | MMKATDMLDA | | SLEPETTSAP | | NMNITSDESL |
AASKATTETE | | AIHVFENTAA | | SHVETTSATE | | ELYSSSPGFS | | EPTKVISPVV |
TSSSIRDNMV | | STTMPGSSGI | | TRIEIESMSS | | LTPGLRETRT | | SQDITSSTET |
STVLYKMPSG | | ATPEVSRTEV | | MPSSRTSIPG | | PAQSTMSLDI | | SDEVVTRLST |
SPIMTESAEI | | TITTQTGYSL | | ATSQVTLPLG | | TSMTFLSGTH | | STMSQGLSHS |
EMTNLMSRGP | | ESLSWTSPRF | | VETTRSSSSL | | TSLPLTTSLS | | PVSSTLLDSS |
PSSPLPVTSL | | ILPGLVKTTE | | VLDTSSEPKT | | SSSPNLSSTS | | VEIPATSEIM |
TDTEKIHPSS | | NTAVAKVRTS | | SSVHESHSSV | | LADSETTITI | | PSMGITSAVD |
DTTVFTSNPA | | FSETRRIPTE | | PTFSLTPGFR | | ETSTSEETTS | | ITETSAVLYG |
VPTSATTEVS | | MTEIMSSNRI | | HIPDSDQSTM | | SPDIITEVIT | | RLSSSSMMSE |
STQMTITTQK | | SSPGATAQST | | LTLATTTAPL | | ARTHSTVPPR | | FLHSEMTTLM |
SRSPENPSWK | | SSLFVEKTSS | | SSSLLSLPVT | | TSPSVSSTLP | | QSIPSSSFSV |
TSLLTPGMVK | | TTDTSTEPGT | | SLSPNLSGTS | | VEILAASEVT | | TDTEKIHPSS |
SMAVTNVGTT | | SSGHELYSSV | | SIHSEPSKAT | | YPVGTPSSMA | | ETSISTSMPA |
NFETTGFEAE | | PFSHLTSGFR | | KTNMSLDTSS | | VTPTNTPSSP | | GSTHLLQSSK |
TDFTSSAKTS | | SPDWPPASQY | | TEIPVDIITP | | FNASPSITES | | TGITSFPESR |
FTMSVTESTH | | HLSTDLLPSA | | ETISTGTVMP | | SLSEAMTSFA | | TTGVPRAISG |
SGSPFSRTES | | GPGDATLSTI | | AESLPSSTPV | | PFSSSTFTTT | | DSSTIPALHE |
ITSSSATPYR | | VDTSLGTESS | | TTEGRLVMVS | | TLDTSSQPGR | | TSSSPILDTR |
MTESVELGTV | | TSAYQVPSLS | | TRLTRTDGIM | | EHITKIPNEA | | AHRGTIRPVK |
GPQTSTSPAS | | PKGLHTGGTK | | RMETTTTALK | | TTTTALKTTS | | RATLTTSVYT |
PTLGTLTPLN | | ASMQMASTIP | | TEMMITTPYV | | FPDVPETTSS | | LATSLGAETS |
TALPRTTPSV | | FNRESETTAS | | LVSRSGAERS | | PVIQTLDVSS | | SEPDTTASWV |
IHPAETIPTV | | SKTTPNFFHS | | ELDTVSSTAT | | SHGADVSSAI | | PTNISPSELD |
ALTPLVTISG | | TDTSTTFPTL | | TKSPHETETR | | TTWLTHPAET | | SSTIPRTIPN |
FSHHESDATP | | SIATSPGAET | | SSAIPIMTVS | | PGAEDLVTSQ | | VTSSGTDRNM |
TIPTLTLSPG | | EPKTIASLVT | | HPEAQTSSAI | | PTSTISPAVS | | RLVTSMVTSL |
AAKTSTTNRA | | LTNSPGEPAT | | TVSLVTHPAQ | | TSPTVPWTTS | | IFFHSKSDTT |
PSMTTSHGAE | | SSSAVPTPTV | | STEVPGVVTP | | LVTSSRAVIS | | TTIPILTLSP |
GEPETTPSMA | | TSHGEEASSA | | IPTPTVSPGV | | PGVVTSLVTS | | SRAVTSTTIP |
ILTFSLGEPE | | TTPSMATSHG | | TEAGSAVPTV | | LPEVPGMVTS | | LVASSRAVTS |
TTLPTLTLSP | | GEPETTPSMA | | TSHGAEASST | | VPTVSPEVPG | | VVTSLVTSSS |
GVNSTSIPTL | | ILSPGELETT | | PSMATSHGAE | | ASSAVPTPTV | | SPGVSGVVTP |
LVTSSRAVTS | | TTIPILTLSS | | SEPETTPSMA | | TSHGVEASSA | | VLTVSPEVPG |
MVTSLVTSSR | | AVTSTTIPTL | | TISSDEPETT | | TSLVTHSEAK | | MISAIPTLAV |
SPTVQGLVTS | | LVTSSGSETS | | AFSNLTVASS | | QPETIDSWVA | | HPGTEASSVV |
PTLTVSTGEP | | FTNISLVTHP | | AESSSTLPRT | | TSRFSHSELD | | TMPSTVTSPE |
AESSSAISTT | | ISPGIPGVLT | | SLVTSSGRDI | | SATFPTVPES | | PHESEATASW |
VTHPAVTSTT | | VPRTTPNYSH | | SEPDTTPSIA | | TSPGAEATSD | | FPTITVSPDV |
PDMVTSQVTS | | SGTDTSITIP | | TLTLSSGEPE | | TTTSFITYSE | | THTSSAIPTL |
PVSPGASKML | | TSLVISSGTD | | STTTFPTLTE | | TPYEPETTAI | | QLIHPAETNT |
MVPRTTPKFS | | HSKSDTTLPV | | AITSPGPEAS | | SAVSTTTISP | | DMSDLVTSLV |
PSSGTDTSTT | | FPTLSETPYE | | PETTATWLTH | | PAETSTTVSG | | TIPNFSHRGS |
DTAPSMVTSP | | GVDTRSGVPT | | TTIPPSIPGV | | VTSQVTSSAT | | DTSTAIPTLT |
PSPGEPETTA | | SSATHPGTQT | | GFTVPIRTVP | | SSEPDTMASW | | VTHPPQTSTP |
VSRTTSSFSH | | SSPDATPVMA | | TSPRTEASSA | | VLTTISPGAP | | EMVTSQITSS |
GAATSTTVPT | | LTHSPGMPET | | TALLSTHPRT | | ETSKTFPAST | | VFPQVSETTA |
SLTIRPGAET | | STALPTQTTS | | SLFTLLVTGT | | SRVDLSPTAS | | PGVSAKTAPL |
STHPGTETST | | MIPTSTLSLG | | LLETTGLLAT | | SSSAETSTST | | LTLTVSPAVS |
GLSSASITTD | | KPQTVTSWNT | | ETSPSVTSVG | | PPEFSRTVTG | | TTMTLIPSEM |
PTPPKTSHGE | | GVSPTTILRT | | TMVEATNLAT | | TGSSPTVAKT | | TTTFNTLAGS |
LFTPLTTPGM | | STLASESVTS | | RTSYNHRSWI | | STTSSYNRRY | | WTPATSTPVT |
STFSPGISTS | | SIPSSTAATV | | PFMVPFTLNF | | TITNLQYEED | | MRHPGSRKFN |
ATERELQGLL | | KPLFRNSSLE | | YLYSGCRLAS | | LRPEKDSSAT | | AVDAICTHRP |
DPEDLGLDRE | | RLYWELSNLT | | NGIQELGPYT | | LDRNSLYVNG | | FTHRSSMPTT |
STPGTSTVDV | | GTSGTPSSSP | | SPTTAGPLLM | | PFTLNFTITN | | LQYEEDMRRT |
GSRKFNTMES | | VLQGLLKPLF | | KNTSVGPLYS | | GCRLTLLRPE | | KDGAATGVDA |
ICTHRLDPKS | | PGLNREQLYW | | ELSKLTNDIE | | ELGPYTLDRN | | SLYVNGFTHQ |
SSVSTTSTPG | | TSTVDLRTSG | | TPSSLSSPTI | | MAAGPLLVPF | | TLNFTITNLQ |
YGEDMGHPGS | | RKFNTTERVL | | QGLLGPIFKN | | TSVGPLYSGC | | RLTSLRSEKD |
GAATGVDAIC | | IHHLDPKSPG | | LNRERLYWEL | | SQLTNGIKEL | | GPYTLDRNSL |
YVNGFTHRTS | | VPTSSTPGTS | | TVDLGTSGTP | | FSLPSPATAG | | PLLVLFTLNF |
TITNLKYEED | | MHRPGSRKFN | | TTERVLQTLL | | GPMFKNTSVG | | LLYSGCRLTL |
LRSEKDGAAT | | GVDAICTHRL | | DPKSPGVDRE | | QLYWELSQLT | | NGIKELGPYT |
LDRNSLYVNG | | FTHWIPVPTS | | STPGTSTVDL | | GSGTPSSLPS | | PTTAGPLLVP |
FTLNFTITNL | | KYEEDMHCPG | | SRKFNTTERV | | LQSLLGPMFK | | NTSVGPLYSG |
CRLTLLRSEK | | DGAATGVDAI | | CTHRLDPKSP | | GVDREQLYWE | | LSQLTNGIKE |
LGPYTLDRNS | | LYVNGFTHQT | | SAPNTSTPGT | | STVDLGTSGT | | PSSLPSPTSA |
GPLLVPFTLN | | FTITNLQYEE | | DMHHPGSRKF | | NTTERVLQGL | | LGPMFKNTSV |
GLLYSGCRLT | | LLRPEKNGAA | | TGMDAICSHR | | LDPKSPGLNR | | EQLYWELSQL |
THGIKELGPY | | TLDRNSLYVN | | GFTHRSSVAP | | TSTPGTSTVD | | LGTSGTPSSL |
PSPTTAVPLL | | VPFTLNFTIT | | NLQYGEDMRH | | PGSRKFNTTE | | RVLQGLLGPL |
FKNSSVGPLY | | SGCRLISLRS | | EKDGAATGVD | | AICTHHLNPQ | | SPGLDREQLY |
WQLSQMTNGI | | KELGPYTLDR | | NSLYVNGFTH | | RSSGLTTSTP | | WTSTVDLGTS |
GTPSPVPSPT | | TTGPLLVPFT | | LNFTITNLQY | | EENMGHPGSR | | KFNITESVLQ |
GLLKPLFKST | | SVGPLYSGCR | | LTLLRPEKDG | | VATRVDAICT | | HRPDPKIPGL |
DRQQLYWELS | | QLTHSITELG | | PYTLDRDSLY | | VNGFTQRSSV | | PTTSTPGTFT |
VQPETSETPS | | SLPGPTATGP | | VLLPFTLNFT | | ITNLQYEEDM | | RRPGSRKFNT |
TERVLQGLLM | | PLFKNTSVSS | | LYSGCRLTLL | | RPEKDGAATR | | VDAVCTHRPD |
PKSPGLDRER | | LYWKLSQLTH | | GITELGPYTL | | DRHSLYVNGF | | THQSSMTTTR |
TPDTSTMHLA | | TSRTPASLSG | | PMTASPLLVL | | FTINFTITNL | | RYEENMHHPG |
SRKFNTTERV | | LQGLLRPVFK | | NTSVGPLYSG | | CRLTLLRPKK | | DGAATKVDAI |
CTYRPDPKSP | | GLDREQLYWE | | LSQLTHSITE | | LGPYTLDRDS | | LYVNGFTQRS |
SVPTTSIPGT | | PTVDLGTSGT | | PVSKPGPSAA | | SPLLVLFTLN | | FTITNLRYEE |
NMQHPGSRKF | | NTTERVLQGL | | LRSLFKSTSV | | GPLYSGCRLT | | LLRPEKDGTA |
TGVDAICTHH | | PDPKSPRLDR | | EQLYWELSQL | | THNITELGPY | | ALDNDSLFVN |
GFTHRSSVST | | TSTPGTPTVY | | LGASKTPASI | | FGPSAASHLL | | ILFTLNFTIT |
NLRYEENMWP | | GSRKFNTTER | | VLQGLLRPLF | | KNTSVGPLYS | | GCRLTLLRPE |
KDGEATGVDA | | ICTHRPDPTG | | PGLDREQLYL | | ELSQLTHSIT | | ELGPYTLDRD |
SLYVNGFTHR | | SSVPTTSTGV | | VSEEPFTLNF | | TINNLRYMAD | | MGQPGSLKFN |
ITDNVMQHLL | | SPLFQRSSLG | | ARYTGCRVIA | | LRSVKNGAET | | RVDLLCTYLQ |
PLSGPGLPIK | | QVFHELSQQT | | HGITRLGPYS | | LDKDSLYLNG | | YNEPGPDEPP |
TTPKPATTFL | | PPLSEATTAM | | GYHLKTLTLN | | FTISNLQYSP | | DMGKGSATFN |
STEGVLQHLL | | RPLFQKSSMG | | PFYLGCQLIS | | LRPEKDGAAT | | GVDTTCTYHP |
DPVGPGLDIQ | | QLYWELSQLT | | HGVTQLGFYV | | LDRDSLFING | | YAPQNLSIRG |
EYQINFHIVN | | WNLSNPDPTS | | SEYITLLRDI | | QDKVTTLYKG | | SQLHDTFRFC |
LVTNLTMDSV | | LVTVKALFSS | | NLDPSLVEQV | | FLDKTLNASF | | HWLGSTYQLV |
DIHVTEMESS | | VYQPTSSSST | | QHFYLNFTIT | | NLPYSQDKAQ | | PGTTNYQRNK |
RNIEDALNQL | | FRNSSIKSYF | | SDCQVSTFRS | | VPNRHHTGVD | | SLCNFSPLAR |
RVDRVAIYEE | | FLRMTRNGTQ | | LQNFTLDRSS | | VLVDGYSPNR | | NEPLTGNSDL |
PFWAVILIGL | | AGLLGVITCL | | ICGVLVTTRR | | RKKEGEYNVQ | | QQCPGYYQSH |
LDLEDLQ |
Кодований геном білок за функцією належить до фосфопротеїнів. Локалізований у клітинній мембрані, а його фрагмент також секретований назовні.
Фізіологічна роль
Муцин-16 синтезується в клітинах епітелію бронхів, ендометрію, яєчників, рогівки. Низка протеаз, зокрема еластаза нейтрофілів, MMP7, MMP9, бактеріальна металопротеаза ZmpC тощо, здатні відщеплювати позаклітинну частину білка від трансмембранного якоря. Функція білка в здорових клітинах маловивчена, хоча встановлено, що в епітелії ока муцин-16 взаємодіє з галектином-3 та цей комплекс захищає око від вірусних та бактеріальних інфекцій.[4]
Медичне значення
1981 року група американських онкологів під керівництвом Роберта Баста (англ. Robert C. Bast) розробила моноклональне антитіло OC125, яке позитивно реагувало з тканиною злоякісної пухлини яєчника, але не взаємодіяло з іншими типами пухлин цього органу. Невідомий на той час білок, який розпізнавало це антитіло, був названий CA125 (від англ. Cancer Antigen). Попри те, що антитіло було створено задля лікування цього виду раку, надалі його почали використовувати для діагностики, зокрема щодо рецидивів раку яєчників. 2001 року було клоновано ген, який кодує цей білок, який виявився приналежним до родини муцинів. [5]
Висока експресія білка на поверхні ракових клітин захищає їх від моноцитів та природних кілерів[4].
Див. також
Література
- O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K. (2002). The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. Tumor Biol. 23: 154—169. PMID 12218296 DOI:10.1159/000064032
- Yin B.W.T., Lloyd K.O. (2001). Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J. Biol. Chem. 276: 27371—27375. PMID 11369781 DOI:10.1074/jbc.M103554200
- McLemore M.R., Aouizerat B. (2005). Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. Biol. Res. Nurs. 6: 262—267. PMID 15788735 DOI:10.1177/1099800404274445
- Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K. (2006). Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye. Invest. Ophthalmol. Vis. Sci. 47: 113—119. PMID 16384952 DOI:10.1167/iovs.05-0735
Примітки
- ↑ Human PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:15582 (англ.) . Архів оригіналу за 28 березня 2016. Процитовано 12 вересня 2017.
- ↑ UniProt, Q8WXI7 (англ.) . Архів оригіналу за 29 серпня 2017. Процитовано 12 вересня 2017.
- ↑ а б Felder, Mildred; Kapur, Arvinder; Gonzalez-Bosquet, Jesus; Horibata, Sachi; Heintz, Joseph; Albrecht, Ralph; Fass, Lucas; Kaur, Justanjyot; Hu, Kevin; Shojaei, Hadi; Whelan, Rebecca J; Patankar, Manish S (2014). MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress. Molecular Cancer. 13 (1): 129. doi:10.1186/1476-4598-13-129. ISSN 1476-4598.
{{cite journal}}
: Обслуговування CS1: Сторінки із непозначеним DOI з безкоштовним доступом (посилання)(англ.) - ↑ Das, S.; Batra, S. K. (2015). Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy. Cancer Research. 75 (22): 4669—4674. doi:10.1158/0008-5472.CAN-15-1050. ISSN 0008-5472.(англ.)
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