Tiroksin 5-dejodinaza
Tiroksin 5-dejodinaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.97.1.11 | ||||||||
CAS broj | 74506-30-2 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Tiroksin 5-dejodinaza (EC 1.97.1.11, dijodotironinska 5'-dejodinaza, jodotironinska 5-dejodinaza, monodejodinaza jodotironinskog unutrašnjeg prstena, tip III jodotironinska dejodinaza) je enzim sa sistematskim imenom akceptor:3,3',5'-trijodo-L-tironin oksidoreduktaza (jodinacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- 3,3',5'-trijodo-L-tironin + jodid + A + H+ L-tiroksin + AH2
Reakcija teče u smeru 5-dejodinacije. Uklanjanje 5-joda, i.e. sa unutrašnjeg prstena, u znatnoj meri inaktivira hormon tiroksin.
Reference
- ^ Chopra, I.J. & Teco, G.N.C. (1982). „Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines”. Endocrinology. 110: 89—97. PMID 7053997.
- ^ Körhle, J. (2002). „Iodothyronine deiodinases”. Methods Enzymol. 347: 125—167. PMID 11898402.
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
- Thyroxine+5-deiodinase на US National Library of Medicine Medical Subject Headings (MeSH)
- п
- р
- у
- EC1 Oksidoreduktaze /spisak
- EC2 Transferaze /spisak
- EC3 Hidrolaze /spisak
- EC4 Lijaze /spisak
- EC5 Izomeraze /spisak
- EC6 Ligaze /spisak
- B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6