Tiroksin 5-dejodinaza

Tiroksin 5-dejodinaza
Identifikatori
EC broj1.97.1.11
CAS broj74506-30-2
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Pretraga
PMCčlanci
PubMedčlanci
NCBIproteini

Tiroksin 5-dejodinaza (EC 1.97.1.11, dijodotironinska 5'-dejodinaza, jodotironinska 5-dejodinaza, monodejodinaza jodotironinskog unutrašnjeg prstena, tip III jodotironinska dejodinaza) je enzim sa sistematskim imenom akceptor:3,3',5'-trijodo-L-tironin oksidoreduktaza (jodinacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:

3,3',5'-trijodo-L-tironin + jodid + A + H+ {\displaystyle \rightleftharpoons } L-tiroksin + AH2

Reakcija teče u smeru 5-dejodinacije. Uklanjanje 5-joda, i.e. sa unutrašnjeg prstena, u znatnoj meri inaktivira hormon tiroksin.

Reference

  1. ^ Chopra, I.J. & Teco, G.N.C. (1982). „Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines”. Endocrinology. 110: 89—97. PMID 7053997. 
  2. ^ Körhle, J. (2002). „Iodothyronine deiodinases”. Methods Enzymol. 347: 125—167. PMID 11898402. 

Literatura

  • Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097. 

Spoljašnje veze

  • Thyroxine+5-deiodinase на US National Library of Medicine Medical Subject Headings (MeSH)
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TemeTipovi
  • B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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