BMP7 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/97/PDB_1m4u_EBI.jpg/250px-PDB_1m4u_EBI.jpg) |
Available structures |
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PDB | Pretraga ortologa: PDBe RCSB |
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List of PDB id codes |
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1BMP, 1LX5, 1LXI, 1M4U |
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Identifikatori |
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Alijasi | BMP7 |
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Spoljašnji ID | OMIM: 112267 MGI: 103302 HomoloGene: 20410 GeneCards: BMP7 |
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Genska lokacija (miš) |
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![Chromosome 2 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Hr. | Chromosome 2 (mouse)[1] |
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| Band | 2 H3|2 95.54 cM | Start | 172,709,805 bp[1] |
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Kraj | 172,782,114 bp[1] |
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Genska ontologija |
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Molecular function | • везивање хепарина • активност цитокина • transforming growth factor beta receptor binding • активност фактора раста • BMP receptor binding • GO:0001948, GO:0016582 везивање за протеине плазме
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Cellular component | • ванћелијска област • GO:0005578 Екстрацелуларни матрикс • ванћелијски простор • везикула • collagen-containing extracellular matrix
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Biological process | • eye development • pattern specification process • skeletal system development • ureteric bud development • negative regulation of neuron differentiation • embryonic pattern specification • mesenchyme development • anatomical structure formation involved in morphogenesis • negative regulation of cell cycle • mesonephros development • odontogenesis of dentin-containing tooth • mesenchymal cell differentiation • negative regulation of mitotic nuclear division • animal organ morphogenesis • metanephric mesenchyme morphogenesis • metanephros development • cellular response to hypoxia • regulation of pathway-restricted SMAD protein phosphorylation • regulation of removal of superoxide radicals • steroid hormone mediated signaling pathway • negative regulation of Notch signaling pathway • negative regulation of cell population proliferation • branching involved in salivary gland morphogenesis • regulation of apoptotic process • SMAD protein signal transduction • ossification • развој бубрега • negative regulation of cell death • tube morphogenesis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of prostatic bud formation • cartilage development • embryonic limb morphogenesis • negative regulation of MAP kinase activity • embryonic camera-type eye morphogenesis • positive regulation of neuron differentiation • positive regulation of cell differentiation • negative regulation of phosphorylation • regulation of branching involved in prostate gland morphogenesis • диференцијација • neuron projection morphogenesis • nephrogenic mesenchyme morphogenesis • positive regulation of heterotypic cell-cell adhesion • epithelial cell differentiation • response to vitamin D • positive regulation of hyaluranon cable assembly • positive regulation of bone mineralization • dendrite development • negative regulation of neurogenesis • regulation of phosphorylation • BMP signaling pathway • positive regulation of osteoblast differentiation • epithelial to mesenchymal transition • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • branching morphogenesis of an epithelial tube • negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis • negative regulation of glomerular mesangial cell proliferation • response to estradiol • monocyte aggregation • metanephric mesenchymal cell proliferation involved in metanephros development • positive regulation of cell death • cell development • negative regulation of striated muscle cell apoptotic process • positive regulation of pathway-restricted SMAD protein phosphorylation • mesoderm formation • response to peptide hormone • cellular response to BMP stimulus • positive regulation of dendrite development • salivary gland morphogenesis • axon guidance • multicellular organism development • positive regulation of peptidyl-threonine phosphorylation • positive regulation of apoptotic process • protein localization to nucleus • embryonic skeletal joint morphogenesis • camera-type eye morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • endocardial cushion formation • pericardium morphogenesis • neural fold elevation formation • hindbrain development • cardiac muscle tissue development • pharyngeal system development • cardiac septum morphogenesis • chorio-allantoic fusion • heart trabecula morphogenesis • allantois development • positive regulation of epithelial to mesenchymal transition • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis • regulation of signaling receptor activity • GO:1901313 positive regulation of gene expression • negative regulation of NIK/NF-kappaB signaling • regulation of MAPK cascade
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Sources:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | n/a | Chr 2: 172.71 – 172.78 Mb |
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PubMed search | [2] | [3] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Koštani morfogenetički protein 7 ili BMP7 (takođe poznat kao osteogenski protein-1 ili OP-1) je protein koji je kod ljudi kodiran BMP7 genom.[4]
Funkcija
Protein kodiran ovim genom je član TGF-β superfamilije. Poput drugih članova familije koštano morfogenetičkih proteina, on ima značajnu ulogu u transformaciji mesenhimalnih ćelija u kost i hrskavicu. Njega inhibira nogin i slični protein, hordin. Smatra se da BMP7 doprinosi koštanoh homeostazi. On je izražen u mozgu, bubrezima i bešiki.[5]
BMP7 indukuje fosforilaciju SMAD1 i SMAD5, koji zatim indukuju transkripciju brojnih osteogenih gena.[6] Pokazano je da je BMP7 tretman dovoljan da se indukuju svi genetički markeri osteoblastne diferencijacije u mnoštvu ćelijskih tipova.[5]
Reference
- ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000008999 - Ensembl, May 2017
- ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (1992). „A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7”. Genomics. 14 (3): 759—62. PMID 1427904. doi:10.1016/S0888-7543(05)80181-8.
- ^ а б Chen D, Zhao M, Mundy GR (2004). „Bone morphogenetic proteins”. Growth Factors. 22 (4): 233—41. PMID 15621726. doi:10.1080/08977190412331279890.
- ^ Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (2001). „Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads”. EMBO J. 20 (15): 4132—42. PMC 149146
. PMID 11483516. doi:10.1093/emboj/20.15.4132.
Literatura
- Xiao HQ, Shi W, Zhang Y, Liang YZ (2009). „[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]”. Nan Fang Yi Ke Da Xue Xue Bao. 29 (4): 671—5. PMID 19403392.
- Murray LA, Hackett TL, Warner SM, et al. (2008). Eickelberg O, ур. „BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.”. PLoS ONE. 3 (12): e4039. PMC 2603595
. PMID 19112509. doi:10.1371/journal.pone.0004039. - Freedman BI, Bowden DW, Ziegler JT, et al. (2009). „Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study”. J. Bone Miner. Res. 24 (10): 1719—27. PMC 2743282
. PMID 19453255. doi:10.1359/jbmr.090501. - Garriock HA, Kraft JB, Shyn SI, et al. (2010). „A genomewide association study of citalopram response in major depressive disorder”. Biol. Psychiatry. 67 (2): 133—8. PMC 2794921
. PMID 19846067. doi:10.1016/j.biopsych.2009.08.029. - Reddi AH (2000). „Bone morphogenetic proteins and skeletal development: the kidney-bone connection”. Pediatr. Nephrol. 14 (7): 598—601. PMID 10912525. doi:10.1007/s004670000364.
- Gautschi OP, Cadosch D, Zellweger R, et al. (2009). „Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7”. J Musculoskelet Neuronal Interact. 9 (1): 53—60. PMID 19240369.
- Alarmo EL, Pärssinen J, Ketolainen JM, et al. (2009). „BMP7 influences proliferation, migration, and invasion of breast cancer cells”. Cancer Lett. 275 (1): 35—43. PMID 18980801. doi:10.1016/j.canlet.2008.09.028.
- Elshaier AM, Hakimiyan AA, Rappoport L, et al. (2009). „Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes”. Arthritis Rheum. 60 (1): 143—54. PMC 2626196
. PMID 19116903. doi:10.1002/art.24151. - Yerges LM, Klei L, Cauley JA, et al. (2009). „High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men”. J. Bone Miner. Res. 24 (12): 2039—49. PMC 2791518
. PMID 19453261. doi:10.1359/jbmr.090524. - Dudas PL, Argentieri RL, Farrell FX (2009). „BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells”. Nephrol. Dial. Transplant. 24 (5): 1406—16. PMID 19056781. doi:10.1093/ndt/gfn662.
- Honsawek S, Chayanupatkul M, Tanavalee A, et al. (2009). „Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study”. Int Orthop. 33 (4): 1171—5. PMC 2898966
. PMID 19301001. doi:10.1007/s00264-009-0751-z. - Sengle G, Ono RN, Lyons KM, et al. (2008). „A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7”. J. Mol. Biol. 381 (4): 1025—39. PMC 2705212
. PMID 18621057. doi:10.1016/j.jmb.2008.06.074. - Mitu G, Hirschberg R (2008). „Bone morphogenetic protein-7 (BMP7) in chronic kidney disease”. Front. Biosci. 13: 4726—39. PMID 18508541. doi:10.2741/3035.
- Brown A, Stock G, Patel AA, et al. (2006). „Osteogenic protein-1 : a review of its utility in spinal applications”. BioDrugs. 20 (4): 243—51. PMID 16831023. doi:10.2165/00063030-200620040-00005.
- Fajardo M, Liu CJ, Egol K (2009). „Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study”. Clin. Orthop. Relat. Res. 467 (12): 3071—8. PMC 2772945
. PMID 19597895. doi:10.1007/s11999-009-0981-9. - Giannoudis PV, Kanakaris NK, Dimitriou R, et al. (2009). „The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions”. Clin. Orthop. Relat. Res. 467 (12): 3239—48. PMC 2772926
. PMID 19396502. doi:10.1007/s11999-009-0846-2. - Kalluri R, Neilson EG (2003). „Epithelial-mesenchymal transition and its implications for fibrosis”. J. Clin. Invest. 112 (12): 1776—84. PMC 297008
. PMID 14679171. doi:10.1172/JCI20530. - Zhu L, Chuanchang D, Wei L, et al. (2010). „Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone”. J. Orthop. Res. 28 (3): 412—8. PMID 19725097. doi:10.1002/jor.20973.
- Vieira AR, McHenry TG, Daack-Hirsch S, et al. (2008). „Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts”. Genet. Med. 10 (9): 668—74. PMC 2734954
. PMID 18978678. doi:10.1097/GIM.0b013e3181833793. - Kron K, Pethe V, Briollais L, et al. (2009). Blagosklonny MV, ур. „Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays”. PLoS ONE. 4 (3): e4830. PMC 2653233
. PMID 19283074. doi:10.1371/journal.pone.0004830.
Spoljašnje veze
- bone morphogenetic protein 7 на US National Library of Medicine Medical Subject Headings (MeSH)
- BMP7 as Molecule of the Year 2011
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1lxi: Refinacija BMP7 kristalne strukture -
1bmp: Koštani morfogenetički protein 7 -
1lx5: Kristalna struktura kompleksa BMP7/ActRII ekstracelularnog domena -
1m4u: Kristalna struktura koštanog morfogenetičkog proteina 7 (BMP-7) u kompleksu sa Noginom |