Koštani morfogenetički protein 7

BMP7
Available structures
PDBPretraga ortologa: PDBe RCSB
List of PDB id codes

1BMP, 1LX5, 1LXI, 1M4U

Identifikatori
AlijasiBMP7
Spoljašnji IDOMIM: 112267 MGI: 103302 HomoloGene: 20410 GeneCards: BMP7
Genska lokacija (miš)
Chromosome 2 (mouse)
Hr.Chromosome 2 (mouse)[1]
Chromosome 2 (mouse)
Genomska lokacija za BMP7
Genomska lokacija za BMP7
Band2 H3|2 95.54 cMStart172,709,805 bp[1]
Kraj172,782,114 bp[1]
Genska ontologija
Molecular function везивање хепарина
активност цитокина
transforming growth factor beta receptor binding
активност фактора раста
BMP receptor binding
GO:0001948, GO:0016582 везивање за протеине плазме
Cellular component ванћелијска област
GO:0005578 Екстрацелуларни матрикс
ванћелијски простор
везикула
collagen-containing extracellular matrix
Biological process eye development
pattern specification process
skeletal system development
ureteric bud development
negative regulation of neuron differentiation
embryonic pattern specification
mesenchyme development
anatomical structure formation involved in morphogenesis
negative regulation of cell cycle
mesonephros development
odontogenesis of dentin-containing tooth
mesenchymal cell differentiation
negative regulation of mitotic nuclear division
animal organ morphogenesis
metanephric mesenchyme morphogenesis
metanephros development
cellular response to hypoxia
regulation of pathway-restricted SMAD protein phosphorylation
regulation of removal of superoxide radicals
steroid hormone mediated signaling pathway
negative regulation of Notch signaling pathway
negative regulation of cell population proliferation
branching involved in salivary gland morphogenesis
regulation of apoptotic process
SMAD protein signal transduction
ossification
развој бубрега
negative regulation of cell death
tube morphogenesis
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
negative regulation of prostatic bud formation
cartilage development
embryonic limb morphogenesis
negative regulation of MAP kinase activity
embryonic camera-type eye morphogenesis
positive regulation of neuron differentiation
positive regulation of cell differentiation
negative regulation of phosphorylation
regulation of branching involved in prostate gland morphogenesis
диференцијација
neuron projection morphogenesis
nephrogenic mesenchyme morphogenesis
positive regulation of heterotypic cell-cell adhesion
epithelial cell differentiation
response to vitamin D
positive regulation of hyaluranon cable assembly
positive regulation of bone mineralization
dendrite development
negative regulation of neurogenesis
regulation of phosphorylation
BMP signaling pathway
positive regulation of osteoblast differentiation
epithelial to mesenchymal transition
GO:0045996 negative regulation of transcription, DNA-templated
negative regulation of NF-kappaB transcription factor activity
branching morphogenesis of an epithelial tube
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
negative regulation of glomerular mesangial cell proliferation
response to estradiol
monocyte aggregation
metanephric mesenchymal cell proliferation involved in metanephros development
positive regulation of cell death
cell development
negative regulation of striated muscle cell apoptotic process
positive regulation of pathway-restricted SMAD protein phosphorylation
mesoderm formation
response to peptide hormone
cellular response to BMP stimulus
positive regulation of dendrite development
salivary gland morphogenesis
axon guidance
multicellular organism development
positive regulation of peptidyl-threonine phosphorylation
positive regulation of apoptotic process
protein localization to nucleus
embryonic skeletal joint morphogenesis
camera-type eye morphogenesis
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
endocardial cushion formation
pericardium morphogenesis
neural fold elevation formation
hindbrain development
cardiac muscle tissue development
pharyngeal system development
cardiac septum morphogenesis
chorio-allantoic fusion
heart trabecula morphogenesis
allantois development
positive regulation of epithelial to mesenchymal transition
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of signaling receptor activity
GO:1901313 positive regulation of gene expression
negative regulation of NIK/NF-kappaB signaling
regulation of MAPK cascade
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

655

12162

Ensembl

ENSG00000101144

ENSMUSG00000008999

UniProt

P18075

P23359

RefSeq (mRNA)

NM_001719

NM_007557

RefSeq (protein)

NP_001710
NP_001710.1

NP_031583

Location (UCSC)n/aChr 2: 172.71 – 172.78 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Koštani morfogenetički protein 7 ili BMP7 (takođe poznat kao osteogenski protein-1 ili OP-1) je protein koji je kod ljudi kodiran BMP7 genom.[4]

Funkcija

Protein kodiran ovim genom je član TGF-β superfamilije. Poput drugih članova familije koštano morfogenetičkih proteina, on ima značajnu ulogu u transformaciji mesenhimalnih ćelija u kost i hrskavicu. Njega inhibira nogin i slični protein, hordin. Smatra se da BMP7 doprinosi koštanoh homeostazi. On je izražen u mozgu, bubrezima i bešiki.[5]

BMP7 indukuje fosforilaciju SMAD1 i SMAD5, koji zatim indukuju transkripciju brojnih osteogenih gena.[6] Pokazano je da je BMP7 tretman dovoljan da se indukuju svi genetički markeri osteoblastne diferencijacije u mnoštvu ćelijskih tipova.[5]

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000008999 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (1992). „A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7”. Genomics. 14 (3): 759—62. PMID 1427904. doi:10.1016/S0888-7543(05)80181-8. 
  5. ^ а б Chen D, Zhao M, Mundy GR (2004). „Bone morphogenetic proteins”. Growth Factors. 22 (4): 233—41. PMID 15621726. doi:10.1080/08977190412331279890. 
  6. ^ Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (2001). „Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads”. EMBO J. 20 (15): 4132—42. PMC 149146 Слободан приступ. PMID 11483516. doi:10.1093/emboj/20.15.4132. 

Literatura

  • Xiao HQ, Shi W, Zhang Y, Liang YZ (2009). „[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]”. Nan Fang Yi Ke Da Xue Xue Bao. 29 (4): 671—5. PMID 19403392. 
  • Murray LA, Hackett TL, Warner SM, et al. (2008). Eickelberg O, ур. „BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.”. PLoS ONE. 3 (12): e4039. PMC 2603595 Слободан приступ. PMID 19112509. doi:10.1371/journal.pone.0004039. 
  • Freedman BI, Bowden DW, Ziegler JT, et al. (2009). „Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study”. J. Bone Miner. Res. 24 (10): 1719—27. PMC 2743282 Слободан приступ. PMID 19453255. doi:10.1359/jbmr.090501. 
  • Garriock HA, Kraft JB, Shyn SI, et al. (2010). „A genomewide association study of citalopram response in major depressive disorder”. Biol. Psychiatry. 67 (2): 133—8. PMC 2794921 Слободан приступ. PMID 19846067. doi:10.1016/j.biopsych.2009.08.029. 
  • Reddi AH (2000). „Bone morphogenetic proteins and skeletal development: the kidney-bone connection”. Pediatr. Nephrol. 14 (7): 598—601. PMID 10912525. doi:10.1007/s004670000364. 
  • Gautschi OP, Cadosch D, Zellweger R, et al. (2009). „Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7”. J Musculoskelet Neuronal Interact. 9 (1): 53—60. PMID 19240369. 
  • Alarmo EL, Pärssinen J, Ketolainen JM, et al. (2009). „BMP7 influences proliferation, migration, and invasion of breast cancer cells”. Cancer Lett. 275 (1): 35—43. PMID 18980801. doi:10.1016/j.canlet.2008.09.028. 
  • Elshaier AM, Hakimiyan AA, Rappoport L, et al. (2009). „Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes”. Arthritis Rheum. 60 (1): 143—54. PMC 2626196 Слободан приступ. PMID 19116903. doi:10.1002/art.24151. 
  • Yerges LM, Klei L, Cauley JA, et al. (2009). „High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men”. J. Bone Miner. Res. 24 (12): 2039—49. PMC 2791518 Слободан приступ. PMID 19453261. doi:10.1359/jbmr.090524. 
  • Dudas PL, Argentieri RL, Farrell FX (2009). „BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells”. Nephrol. Dial. Transplant. 24 (5): 1406—16. PMID 19056781. doi:10.1093/ndt/gfn662. 
  • Honsawek S, Chayanupatkul M, Tanavalee A, et al. (2009). „Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study”. Int Orthop. 33 (4): 1171—5. PMC 2898966 Слободан приступ. PMID 19301001. doi:10.1007/s00264-009-0751-z. 
  • Sengle G, Ono RN, Lyons KM, et al. (2008). „A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7”. J. Mol. Biol. 381 (4): 1025—39. PMC 2705212 Слободан приступ. PMID 18621057. doi:10.1016/j.jmb.2008.06.074. 
  • Mitu G, Hirschberg R (2008). „Bone morphogenetic protein-7 (BMP7) in chronic kidney disease”. Front. Biosci. 13: 4726—39. PMID 18508541. doi:10.2741/3035. 
  • Brown A, Stock G, Patel AA, et al. (2006). „Osteogenic protein-1 : a review of its utility in spinal applications”. BioDrugs. 20 (4): 243—51. PMID 16831023. doi:10.2165/00063030-200620040-00005. 
  • Fajardo M, Liu CJ, Egol K (2009). „Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study”. Clin. Orthop. Relat. Res. 467 (12): 3071—8. PMC 2772945 Слободан приступ. PMID 19597895. doi:10.1007/s11999-009-0981-9. 
  • Giannoudis PV, Kanakaris NK, Dimitriou R, et al. (2009). „The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions”. Clin. Orthop. Relat. Res. 467 (12): 3239—48. PMC 2772926 Слободан приступ. PMID 19396502. doi:10.1007/s11999-009-0846-2. 
  • Kalluri R, Neilson EG (2003). „Epithelial-mesenchymal transition and its implications for fibrosis”. J. Clin. Invest. 112 (12): 1776—84. PMC 297008 Слободан приступ. PMID 14679171. doi:10.1172/JCI20530. 
  • Zhu L, Chuanchang D, Wei L, et al. (2010). „Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone”. J. Orthop. Res. 28 (3): 412—8. PMID 19725097. doi:10.1002/jor.20973. 
  • Vieira AR, McHenry TG, Daack-Hirsch S, et al. (2008). „Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts”. Genet. Med. 10 (9): 668—74. PMC 2734954 Слободан приступ. PMID 18978678. doi:10.1097/GIM.0b013e3181833793. 
  • Kron K, Pethe V, Briollais L, et al. (2009). Blagosklonny MV, ур. „Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays”. PLoS ONE. 4 (3): e4830. PMC 2653233 Слободан приступ. PMID 19283074. doi:10.1371/journal.pone.0004830. 

Spoljašnje veze

  • bone morphogenetic protein 7 на US National Library of Medicine Medical Subject Headings (MeSH)
  • BMP7 as Molecule of the Year 2011
  • п
  • р
  • у
PDB Galerija
  • 1lxi​: Refinacija BMP7 kristalne strukture
    1lxi: Refinacija BMP7 kristalne strukture
  • 1bmp​: Koštani morfogenetički protein 7
    1bmp: Koštani morfogenetički protein 7
  • 1lx5​: Kristalna struktura kompleksa BMP7/ActRII ekstracelularnog domena
    1lx5: Kristalna struktura kompleksa BMP7/ActRII ekstracelularnog domena
  • 1m4u​: Kristalna struktura koštanog morfogenetičkog proteina 7 (BMP-7) u kompleksu sa Noginom
    1m4u: Kristalna struktura koštanog morfogenetičkog proteina 7 (BMP-7) u kompleksu sa Noginom
  • п
  • р
  • у
Lekovi za tretman bolesti kostiju (M05)
Bisfosfonati
Koštani morfogenetički proteini
Drugi
Inhibitor resorpcije (Ipriflavon) • Aluminijum hlorohidrat • Koštani agens dualnog dejstva (Stroncijum ranelat) • RANKL inhibitor (Denosumab) • Katepsin K inhibitor (Odanakatib)

M: BON/CAR

anat(t,c,f,k,f,u,p,l)/phys/devp

noco/cong/tumr, sysi/epon, injr

proc, lek(M5)