Abl (gen)
ABL proto-onkogen 1, nereceptorska tirozinska kinaza | |||||||||||
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![]() PDB prikaz baziran na 1ab2. | |||||||||||
Dostupne strukture | |||||||||||
1AB2, 1ABL, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2F4J, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2O88, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3PYY, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD | |||||||||||
Identifikatori | |||||||||||
Simboli | ABL1; ABL; JTK7; bcr/abl; c-ABL; c-ABL1; p150; v-abl | ||||||||||
Vanjski ID | OMIM: 189980 MGI: 87859 HomoloGene: 3783 GeneCards: ABL1 Gene | ||||||||||
EC broj | 2.7.10.2 | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 25 | 11350 | |||||||||
Ensembl | ENSG00000097007 | ENSMUSG00000026842 | |||||||||
UniProt | P00519 | P00520 | |||||||||
RefSeq (mRNA) | NM_005157 | NM_001112703 | |||||||||
RefSeq (protein) | NP_005148 | NP_001106174 | |||||||||
Lokacija (UCSC) | Chr 9: 133.59 - 133.76 Mb | Chr 2: 31.69 - 31.8 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Abelsonov mišji leukemijski viralni onkogen homolog 1 (ABL1) protein je koji je kod ljudi kodiran ABL1 genom (raniji simbol ABL) lociranim na hromozomu 9.[1] c-Abl se ponekad koristi za imenovanje verzije gena prisutnog u genomu sisara, dok se v-Abl odnosi na viralni gen.
Interakcije
Abl gen formira interakcije sa:
- ABI1,[2][3][4]
- ABI2,[5][6]
- ABL2,[5]
- ATM,[7][8][9]
- BCAR1,[10][11]
- BCR,[12][13][14]
- BRCA1,[15]
- CAT,[16]
- CBL,[17][18]
- CRKL,[19][20][21]
- DOK1,[22][23]
- EPHB2,[24]
- GPX1,[25]
- GRB10,[26][27]
- MTOR,[28]
- GRB2,[19][29]
- MDM2,[30]
- NCK1,[17][19]
- NEDD9,[31][32]
- NTRK1,[33][34]
- P73,[35][36]
- PAG1,[37]
- PAK2,[38]
- PSTPIP1,[39]
- RAD9A,[40]
- RAD51,[7]
- RB1,[41][42]
- RFX1,[43]
- RYBP,[44]
- SHC1,[12][45]
- SORBS2,[18][46]
- SPTA1,[47]
- SPTAN1,[47]
- TERF1,[9]
- VAV1,[48] and
- YTHDC1.[49]
Regulacija
Postoje izvesni dokazi da je izražavanje Abl regulisano posredstvom mikroRNK miR-203.[50]
Vidi još
- BCR gen
Reference
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Literatura
- Shore SK, Tantravahi RV, Reddy EP (decembar 2002). „Transforming pathways activated by the v-Abl tyrosine kinase”. Oncogene. 21 (56): 8568—76. PMID 12476303. doi:10.1038/sj.onc.1206084.
- Shaul Y (2000). „c-Abl: activation and nuclear targets”. Cell Death Differ. 7 (1): 10—6. PMID 10713716. doi:10.1038/sj.cdd.4400626.
- Era T (2002). „Bcr-Abl is a "molecular switch" for the decision for growth and differentiation in hematopoietic stem cells”. Int. J. Hematol. 76 (1): 35—43. PMID 12138893. doi:10.1007/BF02982716.
- Pendergast AM (2003). „The Abl family kinases: mechanisms of regulation and signaling”. Adv. Cancer Res. 85: 51—100. PMID 12374288. doi:10.1016/S0065-230X(02)85003-5.
- Keung YK, Beaty M, Steward W, et al. (2003). „Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature”. Cancer Genet. Cytogenet. 138 (2): 139—42. PMID 12505259. doi:10.1016/S0165-4608(02)00609-X.
- Saglio G, Cilloni D (2005). „Abl: the prototype of oncogenic fusion proteins”. Cell. Mol. Life Sci. 61 (23): 2897—911. PMID 15583852. doi:10.1007/s00018-004-4271-0.
- Shaul Y, Ben-Yehoyada M (2005). „Role of c-Abl in the DNA damage stress response”. Cell Res. 15 (1): 33—5. PMID 15686624. doi:10.1038/sj.cr.7290261.
- Yoshida K (2007). „Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage”. Adv. Exp. Med. Biol. 604: 155—65. PMID 17695727. doi:10.1007/978-0-387-69116-9_15.
Spoljašnje veze
- Genes,+abl на US National Library of Medicine Medical Subject Headings (MeSH)
- Online Mendelovsko nasleđivanje kod čoveka (OMIM) 189980 (ABL)
- Abelson+Leukemia+Virus на US National Library of Medicine Medical Subject Headings (MeSH)
- Drosophila Abl tyrosine kinase - The Interactive Fly
- ABL1 Info with links in the Cell Migration Gateway
- ABL1 on the Atlas of Genetics and Cytogenetics in Oncology and Haematology