Tioredoksin-disulfid reduktaza
| Tioredoksin-disulfid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Tioredoksin-disulfid reduktaza 1, dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.8.1.9 | ||||||||
| CAS broj | 9074-14-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Tioredoksin-disulfid reduktaza (EC 1.8.1.9, NADP-tioredoksin reduktaza, NADPH-tioredoksin reduktaza, tioredoksin reduktaza (NADPH), NADPH2:oksidovani tioredoksin oksidoreduktaza) je enzim sa sistematskim imenom tioredoksin:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tioredoksin + NADP+ tioredoksin disulfid + NADPH + H+
Ovaj enzim je flavoprotein (FAD).
Reference
- ↑ Moore, E.C., Reichard, P. and Thelander, L. (1964). „Enzymatic synthesis of deoxyribonucleotides. V. Purification and properties of thioredoxin reductase from Escherichia coli B”. J. Biol. Chem. 239: 3445-3452. PMID 14245401.
- ↑ Speranza, M.L., Ronchi, S. and Minchiotti, L. (1973). „Purification and characterization of yeast thioredoxin reductase”. Biochim. Biophys. Acta 327: 274-281. PMID 4149839.
- ↑ Arner, E.S. and Holmgren, A. (2000). „Physiological functions of thioredoxin and thioredoxin reductase”. Eur. J. Biochem. 267: 6102-6109. PMID 11012661.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Thioredoxin-disulfide+reductase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
