Ribozilpirimidinska nukleozidaza
| Ribozilpirimidinska nukleozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.8 | ||||||||
| CAS broj | 37288-60-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ribozilpirimidinska nukleozidaza (EC 3.2.2.8, N-ribozilpirimidinska nukleozidaza, pirimidinska nukleozidaza, N-ribozilpirimidinska ribohidrolaza, pirimidinska nukleozidna hidrolaza, RihB, YeiK, nukleozidna ribohidrolaza) je enzim sa sistematskim imenom pirimidin-nukleozidna ribohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- pirimidinski nukleozid + H2O D-riboza + pirimidinska baza
Ovaj enzim takođe u manjoj meri hidrolizuje purin D-ribonukleozide. 2'-, 3'- i 5'-dezoksinukleozidi nisu supstrati.
Reference
- ↑ Terada, M., Tatibana, M. and Hayaishi, O. (1967). „Preparation and properties of nucleoside hydrolase from Pseudomonas fluorescens”. J. Biol. Chem. 242: 5578-5585. PMID 12325375.
- ↑ Petersen, C. and Møller, L.B. (2001). „The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation”. J. Biol. Chem. 276: 884-894. PMID 11027694.
- ↑ Giabbai, B. and Degano, M. (2004). „Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK”. Acta Crystallogr. D Biol. Crystallogr. 60: 524-527. PMID 14993681.
- ↑ Giabbai, B. and Degano, M. (2004). „Crystal structure to 1.7 Å of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy”. Structure 12: 739-749. PMID 15130467.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Ribosylpyrimidine+nucleosidase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
