Purinska nukleozidaza
| Purinska nukleozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Purinska nukleozidaza tetramer, Saccharolobus solfataricus | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.2.2.1 | ||||||||
| CAS broj | 9025-44-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Purinska nukleozidaza (EC 3.2.2.1, nukleozidaza, purin beta-ribozidaza, purin nukleozidna hidrolaza, purinska ribonukleozidaza, ribonukleozidna hidrolaza, nukleozidna hidrolaza, N-ribozil purinska ribohidrolaza, nukleozidaza g, N-D-ribozilpurinska ribohidrolaza, inozin-adenozin-guanozin preferentna nukleozidna hidrolaza, purin-specifična nukleozidna N-ribohidrolaza, IAG-nukleozidna hidrolaza, IAG-NH) je enzim sa sistematskim imenom purin-nukleozidna ribohidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- purinski nukleozid + H2O D-riboza + purinska baza
Enzim iz bakterije Ochrobactrum anthropi specifično katalizuje ireverzibilnu N-ribozidnu hidrolizu purinskih nukleozida.
Reference
- ↑ Heppel, L.A. and Hilmoe, R.J. (1952). „Phosphorolysis and hydrolysis of purine ribosides from yeast”. J. Biol. Chem. 198: 683-694. PMID 12999785.
- ↑ Kalckar, H.M. (1951). „Biosynthetic aspects of nucleosides and nucleic acids”. Pubbl. Staz. Zool. (Napoli) 23: 87-103.
- ↑ Takagi, Y. and Horecker, B.L. (1956). „Purification and properties of a bacterial riboside hydrolyase”. J. Biol. Chem. 225: 77-86. PMID 13416219.
- ↑ Tarr, H.L.A. (1955). „Fish muscle riboside hydrolases”. Biochem. J. 59: 386-391. PMID 14363106.
- ↑ Parkin, D.W. (1996). „Purine-specific nucleoside N-ribohydrolase from 'Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism”. J. Biol. Chem. 271: 21713-21719. PMID 8702965.
- ↑ Ogawa, J., Takeda, S., Xie, S.X., Hatanaka, H., Ashikari, T., Amachi, T. and Shimizu, S. (2001). „Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropi”. Appl. Environ. Microbiol. 67: 1783-1787. PMID 11282633.
- ↑ Versées, W., Decanniere, K., Van Holsbeke, E., Devroede, N. and Steyaert, J. (2002). „Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax”. J. Biol. Chem. 277: 15938-15946. PMID 11854281.
- ↑ Mazumder-Shivakumar, D. and Bruice, T.C. (2005). „Computational study of IAG-nucleoside hydrolase: determination of the preferred ground state conformation and the role of active site residues”. Biochemistry 44: 7805-7817. PMID 15909995.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Purine+nucleosidase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
