Protein višestrukog PDZ domena

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PDB prikaz baziran na 2fcf.

Dostupne strukture

2FCF, 2FNE, 2IWN, 2IWO, 2IWP, 2IWQ, 2O2T, 2OPG, 2QG1

Identifikatori

Simboli

MPDZ; MUPP1

Vanjski ID

OMIM: 603785 MGI: 1343489 HomoloGene: 2841 GeneCards: MPDZ Gene

Ontologija gena
Molekularna funkcija	• proteinsko vezivanje • vezivanje protein C-terminusa
Celularna komponenta	• citoplazma • postsinaptička gustina • apikalna ćelijska membran
Biološki proces	• ćelijska adhezija • virus-domaćin interacija

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

8777

17475

Ensembl

ENSG00000107186

ENSMUSG00000028402

UniProt

O75970

Q8VBX6

RefSeq (mRNA)

NM_001261406.1

NM_010820.2

RefSeq (protein)

NP_001248335.1

NP_034950.2

Lokacija (UCSC)

Chr 9:
13.11 - 13.28 Mb

Chr 4:
81.28 - 81.44 Mb

PubMed pretraga

[1]

[2]

Protein višestrukog PDZ domena je protein koji je kod ljudi kodiran MPDZ genom.^[1]

Interakcije

MPDZ formira interakcije sa CD117,^[2] PLEKHA1^[3] i 5-HT2C receptor.^[4]^[5]

Reference

↑ „Entrez Gene: MPDZ multiple PDZ domain protein”.
↑ Mancini, A; Koch A, Stefan M, Niemann H, Tamura T (September 2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Lett. (NETHERLANDS) 482 (1–2): 54–8. DOI:10.1016/S0014-5793(00)02036-6. ISSN 0014-5793. PMID 11018522.
↑ Kimber, Wendy A; Trinkle-Mulcahy Laura, Cheung Peter C F, Deak Maria, Marsden Louisa J, Kieloch Agnieszka, Watt Stephen, Javier Ronald T, Gray Alex, Downes C Peter, Lucocq John M, Alessi Dario R (February 2002). „Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo”. Biochem. J. (England) 361 (Pt 3): 525–36. DOI:10.1042/0264-6021:3610525. ISSN 0264-6021. PMC 1222335. PMID 11802782.
↑ Becamel, C; Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (April 2001). „Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1”. J. Biol. Chem. (United States) 276 (16): 12974–82. DOI:10.1074/jbc.M008089200. ISSN 0021-9258. PMID 11150294.
↑ Ullmer, C; Schmuck K, Figge A, Lübbert H (March 1998). „Cloning and characterization of MUPP1, a novel PDZ domain protein”. FEBS Lett. (NETHERLANDS) 424 (1–2): 63–8. DOI:10.1016/S0014-5793(98)00141-0. ISSN 0014-5793. PMID 9537516.

Literatura

Ullmer C, Schmuck K, Figge A, Lübbert H (1998). „Cloning and characterization of MUPP1, a novel PDZ domain protein”. FEBS Lett. 424 (1–2): 63–8. DOI:10.1016/S0014-5793(98)00141-0. PMID 9537516.
Barritt DS, Pearn MT, Zisch AH i dr.. (2000). „The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2”. J. Cell. Biochem. 79 (2): 213–24. DOI:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMID 10967549.
Lee SS, Glaunsinger B, Mantovani F i dr.. (2000). „Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins”. J. Virol. 74 (20): 9680–93. DOI:10.1128/JVI.74.20.9680-9693.2000. PMC 112400. PMID 11000240.
Mancini A, Koch A, Stefan M i dr.. (2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Lett. 482 (1–2): 54–8. DOI:10.1016/S0014-5793(00)02036-6. PMID 11018522.
Becamel C, Figge A, Poliak S i dr.. (2001). „Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1”. J. Biol. Chem. 276 (16): 12974–82. DOI:10.1074/jbc.M008089200. PMID 11150294.
Vassilev A, Kaneko KJ, Shu H i dr.. (2001). „TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm”. Genes Dev. 15 (10): 1229–41. DOI:10.1101/gad.888601. PMC 313800. PMID 11358867.
Hamazaki Y, Itoh M, Sasaki H i dr.. (2002). „Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule”. J. Biol. Chem. 277 (1): 455–61. DOI:10.1074/jbc.M109005200. PMID 11689568.
Kimber WA, Trinkle-Mulcahy L, Cheung PC i dr.. (2002). „Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo”. Biochem. J. 361 (Pt 3): 525–36. DOI:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.
Poliak S, Matlis S, Ullmer C i dr.. (2002). „Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells”. J. Cell Biol. 159 (2): 361–72. DOI:10.1083/jcb.200207050. PMC 2173042. PMID 12403818.
Griffon N, Jeanneteau F, Prieur F i dr.. (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. 117 (1): 47–57. DOI:10.1016/S0169-328X(03)00283-3. PMID 14499480.
Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR i dr.. (2004). „DNA sequence and analysis of human chromosome 9”. Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053.
Krapivinsky G, Medina I, Krapivinsky L i dr.. (2004). „SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation”. Neuron 43 (4): 563–74. DOI:10.1016/j.neuron.2004.08.003. PMID 15312654.
van de Pavert SA (2005). „Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure”. J. Cell. Sci. 117 (Pt 18): 4169–77. DOI:10.1242/jcs.01301. PMID 15316081.
Coyne CB, Voelker T, Pichla SL, Bergelson JM (2005). „The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction”. J. Biol. Chem. 279 (46): 48079–84. DOI:10.1074/jbc.M409061200. PMID 15364909.
Okuhira K, Fitzgerald ML, Sarracino DA i dr.. (2006). „Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux”. J. Biol. Chem. 280 (47): 39653–64. DOI:10.1074/jbc.M510187200. PMID 16192269.
Heydecke D, Meyer D, Ackermann F i dr.. (2006). „The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa”. J. Androl. 27 (3): 390–404. DOI:10.2164/jandrol.05166. PMID 16452527.
Olsen JV, Blagoev B, Gnad F i dr.. (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983.
Szafranski K, Schindler S, Taudien S i dr.. (2007). „Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns”. Genome Biology 8 (8): R154. DOI:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.