• proteinska fosfataza tip 2A kompleks • hromozom, centromerni region • pol vretena • nukleus • mitohondrija
Biološki proces
• nuklearno-transkribovani iRNK katabolički proces • inaktivacija MAPK aktivnosti • regulacija DNK replikacija • regulacija transkripcije, DNK-zavisna
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta
Čovek
Miš
Entrez
5515
19052
Ensembl
ENSG00000113575
ENSMUSG00000020349
UniProt
P67775
P63330
RefSeq (mRNA)
NM_002715.2
NM_019411.4
RefSeq (protein)
NP_002706.1
NP_062284.1
Lokacija (UCSC)
Chr 5: 133.53 - 133.56 Mb
Chr 11: 52.1 - 52.13 Mb
PubMed pretraga
[1]
[2]
Serin/treonin proteinska fosfataza 2A katalitička podjedinica alfa izoforma je enzim koji je kod ljudi kodiran PPP2CA genom.[1]
Proteinska fosfataza 2A je jedna od četiri glavne Ser/Thr fosfataze. Ona učestvuje u negativnoj kontroli ćelijskog rasta i deobe. Ona se sastoji od heteromerne enzimske osnove, koji ima katalitičku i konstantnu regulatornu podjedinicu, za koji se vezuje niz regulatornih podjedinica. Ovaj gen kodira alfa izoformu katalitičke podjedinice.[2]
↑Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). „Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively”. Cytogenet Cell Genet63 (1): 35–41. DOI:10.1159/000133497. PMID 8383590.
↑Bennin, David A; Don Aruni S Arachchige, Brake Tiffany, McKenzie Jennifer L, Rosenbaum Heidi, Ortiz Linette, DePaoli-Roach Anna A, Horne Mary C (July 2002). „Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest”. J. Biol. Chem. (United States) 277 (30): 27449–67. DOI:10.1074/jbc.M111693200. ISSN 0021-9258. PMID 11956189.
↑ 4,004,014,024,034,044,054,064,074,084,094,104,114,124,134,144,15Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). „A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein”. Mol. Cell Proteomics (United States) 8 (1): 157–71. DOI:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
↑Marmorstein, Lihua Y; McLaughlin Precious J, Stanton J Brett, Yan Lin, Crabb John W, Marmorstein Alan D (August 2002). „Bestrophin interacts physically and functionally with protein phosphatase 2A”. J. Biol. Chem. (United States) 277 (34): 30591–7. DOI:10.1074/jbc.M204269200. ISSN 0021-9258. PMID 12058047.
↑Kawabe, T; Muslin A J, Korsmeyer S J (January 1997). „HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint”. Nature (ENGLAND) 385 (6615): 454–8. DOI:10.1038/385454a0. ISSN 0028-0836. PMID 9009195.
↑Deng, X; Ito T, Carr B, Mumby M, May W S (December 1998). „Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A”. J. Biol. Chem. (UNITED STATES) 273 (51): 34157–63. DOI:10.1074/jbc.273.51.34157. ISSN 0021-9258. PMID 9852076.
↑Yan, Z; Fedorov S A, Mumby M C, Williams R S (February 2000). „PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells”. Mol. Cell. Biol. (UNITED STATES) 20 (3): 1021–9. DOI:10.1128/MCB.20.3.1021-1029.2000. ISSN 0270-7306. PMC 85219. PMID 10629059.
↑ 9,09,1Cheng, A; Kaldis P, Solomon M J (November 2000). „Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms”. J. Biol. Chem. (UNITED STATES) 275 (44): 34744–9. DOI:10.1074/jbc.M006210200. ISSN 0021-9258. PMID 10934208.
↑Chen, J; Peterson R T, Schreiber S L (June 1998). „Alpha 4 associates with protein phosphatases 2A, 4, and 6”. Biochem. Biophys. Res. Commun. (UNITED STATES) 247 (3): 827–32. DOI:10.1006/bbrc.1998.8792. ISSN 0006-291X. PMID 9647778.
↑Chung, H; Nairn A C, Murata K, Brautigan D L (August 1999). „Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2”. Biochemistry (UNITED STATES) 38 (32): 10371–6. DOI:10.1021/bi990902g. ISSN 0006-2960. PMID 10441131.
↑ 13,013,113,213,313,4McCright, B; Rivers A M, Audlin S, Virshup D M (September 1996). „The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm”. J. Biol. Chem. (UNITED STATES) 271 (36): 22081–9. DOI:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017.
↑Kamibayashi, C; Lickteig R L, Estes R, Walter G, Mumby M C (October 1992). „Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits”. J. Biol. Chem. (UNITED STATES) 267 (30): 21864–72. ISSN 0021-9258. PMID 1328247.
↑ 15,015,1Zhou, Jin; Pham Huong T, Ruediger Ralf, Walter Gernot (January 2003). „Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution”. Biochem. J. (England) 369 (Pt 2): 387–98. DOI:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081.
↑Ito, A; Kataoka T R, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (February 2000). „A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation”. EMBO J. (ENGLAND) 19 (4): 562–71. DOI:10.1093/emboj/19.4.562. ISSN 0261-4189. PMC 305594. PMID 10675325.
Literatura
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McCright B, Rivers AM, Audlin S, Virshup DM (1996). „The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.”. J. Biol. Chem.271 (36): 22081–9. DOI:10.1074/jbc.271.36.22081. PMID 8703017.
