Matrilizin
| Matrilizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.23 | ||||||||
| CAS broj | 141256-52-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Matrilizin (EC 3.4.24.23, matrin, uterinska metaloendopeptidaza, matriks metaloproteinaza 7, matriks metaloproteinazna pumpa 1, MMP 7, PUMP-1 proteinaza, PUMP, metaloproteinazna pumpa-1, MMP) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Ala14-Leu i Tyr16-Leu u B lancu insulina. Ne dolazi do razlaganja kolagenskih tipova I, II, IV, V. Razlaže se želatinski lanac alfa2(I) > alfa1(I)
Ovaj enzim je prisutan u materici pacova.
Reference
- ↑ Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J. and Breathnach, R. (1988). „The collagenase gene family in humans consists of at least four members”. Biochem. J. 253: 187-192. PMID 2844164.
- ↑ Woessner, J.F., Jr. and Taplin, C.J. (1988). „Purification and properties of a small latent matrix metalloproteinase of the rat uterus”. J. Biol. Chem. 263: 16918-16925. PMID 3182822.
- ↑ Quantin, B., Murphy, G. and Breathnach, R. (1989). „Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members”. Biochemistry 28: 5327-5334. PMID 2550050.
- ↑ Miyazaki, K., Hattori, Y., Umenishi, F., Yasumitsu, H. and Umeda, M. (1990). „Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line”. Cancer Res. 50: 7758-7764. PMID 2253219.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Matrilysin
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
