Magnolizin
Magnolizin | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.24.62 | ||||||||
CAS broj | 162875-09-4 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Magnolizin (EC 3.4.24.62, prooksitocin/neurofizin konvertaza, prooksifizinska proteinaza, prooksitocinska konvertaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza polipeptida sa Arg ili Lys u P1 i P2, e.g. hidroliza prooksitocina u -Lys-Arg-Ala-Val-. Dalja specifičnos je zavisna od organizacije beta-zaokret-alfa-heliksa sa devet ili više ostataka koji sadrže parove baznih aminokiselina blizo centra
Ova endopeptidaza je prisutna u goveđoj hipofizi.
Reference
- ↑ Clamagirand, C., Creminon, C., Fahy, C., Boussetta, H. and Cohen, P. (1987). „Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytosin/neurophysin peptides at the basic amino acid doublet”. Biochemistry 26: 6018-6023. PMID 2825769.
- ↑ Créminon, C., Rholam, M., Boussetta, H., Marrakchi, N. and Cohen, P. (1988). „Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme”. J. Chromatogt. 440: 439-448. PMID 3042797.
- ↑ Brakch, N., Boussetta, H., Rholam, M. and Cohen, P. (1989). „Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model”. J. Biol. Chem. 264: 15912-15916. PMID 2674120.
- ↑ Plevrakis, I, Créminon, C., Clamagirand, C., Brakch, N., Rholam, M. and Cohen, P. (1989). „Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor”. Biochemistry 28: 2705-2710. PMID 2659078.
- ↑ Guillou, M.D., Camier, M. and Clamagirand, C. (1994). „Evidence for the presence of pro-oxytocin/neurophysin converting enzyme in the human ovary”. J. Endocrinol. 142: 345-352. PMID 7931007.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Magnolysin
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6