• citokinska aktivnost • proteinsko vezivanje • aktivnost faktora rasta
Ćelijska komponenta
• ekstracelularni region • ekstracelularni prostor
Biološki proces
• rezviće skeletalnog sistema • osifikacija • metanefrosno razviće
Ortolozi
Vrsta
Čovek
Miš
Entrez
655
12162
Ensembl
ENSG00000101144
ENSMUSG00000008999
UniProt
P18075
P23359
Ref. Sekv. (iRNK)
NM_001719
NM_007557
Ref. Sekv. (protein)
NP_001710
NP_031583
Lokacija (UCSC)
Chr 20: 55.74 - 55.84 Mb
Chr 2: 172.87 - 172.94 Mb
PubMed pretraga
[1]
[2]
Koštani morfogenetički protein 7 ili BMP7 (takođe poznat kao osteogenski protein-1 ili OP-1) je protein koji je kod ljudi kodiran BMP7 genom.[1]
Sadržaj
1Funkcija
2Reference
3Literatura
4Vanjske veze
Funkcija
Protein kodiran ovim genom je član TGF-β superfamilije. Poput drugih članova familije koštano morfogenetičkih proteina, on ima značajnu ulogu u transformaciji mesenhimalnih ćelija u kost i hrskavicu. Njega inhibira nogin i slični protein, hordin. Smatra se da BMP7 doprinosi koštanoh homeostazi. On je izražen u mozgu, bubrezima i bešiki.[2]
BMP7 indukuje fosforilaciju SMAD1 i SMAD5, koji zatim indukuju transkripciju brojnih osteogenih gena.[3] Pokazano je da je BMP7 tretman dovoljan da se indukuju svi genetički markeri osteoblastne diferencijacije u mnoštvu ćelijskih tipova.[2]
Reference
↑Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (November 1992). „A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7”. Genomics14 (3): 759–62. DOI:10.1016/S0888-7543(05)80181-8. PMID 1427904.
↑ 2,02,1Chen D, Zhao M, Mundy GR (December 2004). „Bone morphogenetic proteins”. Growth Factors22 (4): 233–41. DOI:10.1080/08977190412331279890. PMID 15621726.
↑Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). „Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads”. EMBO J.20 (15): 4132–42. DOI:10.1093/emboj/20.15.4132. PMC 149146. PMID 11483516.
Literatura
Xiao HQ, Shi W, Zhang Y, Liang YZ (2009). „[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]”. Nan Fang Yi Ke Da Xue Xue Bao29 (4): 671–5. PMID 19403392.
Murray LA, Hackett TL, Warner SM, et al. (2008). Eickelberg, Oliver. ur. „BMP-7 does not protect against bleomycin-induced lung or skin fibrosis.”. PLoS ONE3 (12): e4039. DOI:10.1371/journal.pone.0004039. PMC 2603595. PMID 19112509.
Freedman BI, Bowden DW, Ziegler JT, et al. (2009). „Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study”. J. Bone Miner. Res.24 (10): 1719–27. DOI:10.1359/jbmr.090501. PMC 2743282. PMID 19453255.
Garriock HA, Kraft JB, Shyn SI, et al. (2010). „A genomewide association study of citalopram response in major depressive disorder”. Biol. Psychiatry67 (2): 133–8. DOI:10.1016/j.biopsych.2009.08.029. PMC 2794921. PMID 19846067.
Reddi AH (2000). „Bone morphogenetic proteins and skeletal development: the kidney-bone connection”. Pediatr. Nephrol.14 (7): 598–601. DOI:10.1007/s004670000364. PMID 10912525.
Gautschi OP, Cadosch D, Zellweger R, et al. (2009). „Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7”. J Musculoskelet Neuronal Interact9 (1): 53–60. PMID 19240369.
Alarmo EL, Pärssinen J, Ketolainen JM, et al. (2009). „BMP7 influences proliferation, migration, and invasion of breast cancer cells”. Cancer Lett.275 (1): 35–43. DOI:10.1016/j.canlet.2008.09.028. PMID 18980801.
Elshaier AM, Hakimiyan AA, Rappoport L, et al. (2009). „Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes”. Arthritis Rheum.60 (1): 143–54. DOI:10.1002/art.24151. PMC 2626196. PMID 19116903.
Yerges LM, Klei L, Cauley JA, et al. (2009). „High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men”. J. Bone Miner. Res.24 (12): 2039–49. DOI:10.1359/jbmr.090524. PMC 2791518. PMID 19453261.
Dudas PL, Argentieri RL, Farrell FX (2009). „BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells”. Nephrol. Dial. Transplant.24 (5): 1406–16. DOI:10.1093/ndt/gfn662. PMID 19056781.
Honsawek S, Chayanupatkul M, Tanavalee A, et al. (2009). „Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study”. Int Orthop33 (4): 1171–5. DOI:10.1007/s00264-009-0751-z. PMC 2898966. PMID 19301001.
Sengle G, Ono RN, Lyons KM, et al. (2008). „A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7”. J. Mol. Biol.381 (4): 1025–39. DOI:10.1016/j.jmb.2008.06.074. PMC 2705212. PMID 18621057.
Mitu G, Hirschberg R (2008). „Bone morphogenetic protein-7 (BMP7) in chronic kidney disease”. Front. Biosci.13: 4726–39. PMID 18508541.
Brown A, Stock G, Patel AA, et al. (2006). „Osteogenic protein-1 : a review of its utility in spinal applications”. BioDrugs20 (4): 243–51. DOI:10.2165/00063030-200620040-00005. PMID 16831023.
Fajardo M, Liu CJ, Egol K (2009). „Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study”. Clin. Orthop. Relat. Res.467 (12): 3071–8. DOI:10.1007/s11999-009-0981-9. PMC 2772945. PMID 19597895.
Giannoudis PV, Kanakaris NK, Dimitriou R, et al. (2009). „The synergistic effect of autograft and BMP-7 in the treatment of atrophic nonunions”. Clin. Orthop. Relat. Res.467 (12): 3239–48. DOI:10.1007/s11999-009-0846-2. PMC 2772926. PMID 19396502.
Kalluri R, Neilson EG (2003). „Epithelial-mesenchymal transition and its implications for fibrosis”. J. Clin. Invest.112 (12): 1776–84. DOI:10.1172/JCI20530. PMC 297008. PMID 14679171.
Zhu L, Chuanchang D, Wei L, et al. (2010). „Enhanced healing of goat femur-defect using BMP7 gene-modified BMSCs and load-bearing tissue-engineered bone”. J. Orthop. Res.28 (3): 412–8. DOI:10.1002/jor.20973. PMID 19725097.
Vieira AR, McHenry TG, Daack-Hirsch S, et al. (2008). „Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts”. Genet. Med.10 (9): 668–74. DOI:10.1097/GIM.0b013e3181833793. PMC 2734954. PMID 18978678.
Kron K, Pethe V, Briollais L, et al. (2009). Blagosklonny, Mikhail V.. ur. „Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays”. PLoS ONE4 (3): e4830. DOI:10.1371/journal.pone.0004830. PMC 2653233. PMID 19283074.
