INHA

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Inhibin, alfa
Identifikatori
SimbolINHA
Vanjski IDOMIM: 147380 MGI: 96569 HomoloGene: 1652 GeneCards: INHA Gene
Ontologija gena
Molekularna funkcija • receptorsko vezivanje
• citokinska aktivnost
• hormonska aktivnost
Celularna komponenta • fotoreceptorski spoljašnji segment
• fotoreceptorski unutrašnji segment
• ekstracelularni region
Biološki proces • razviće skeletalnog sistema
• razviće folikula jajnika
• indukcija apoptoze
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez362316322
EnsemblENSG00000123999ENSMUSG00000032968
UniProtP05111Q04997
RefSeq (mRNA)NM_002191.3NM_010564.4
RefSeq (protein)NP_002182.1NP_034694.3
Lokacija (UCSC)Chr 2:
220.43 - 220.44 Mb		Chr 1:
75.51 - 75.51 Mb
PubMed pretraga[1][2]

Inhibin, alfa (INHA) je protein koji je kod ljudi kodiran INHA genom.[1]

Funkcija

Inhibin alfa podjedinica zajedno sa još jednom beta A ili beta B podjedinicom formira hipofizni FSH sekretorni inhibitor. Inhibin negativno reguliše proliferaciju gonadalnih stromalnih ćelija i ima supresivno dejstvo na tumour. Serumski nivoi inhibina odražavaju veličinu granulosa-ćelija tumora i mogu se koristiti kao marker za primarnu kao i rekurentnu bolest. Kod kancera prostate, izražavanje gena inhibin alfa-podjedinice je potisnuto i ne može se detektovati kod slabo diferenciranih ćelija tumora.[2]

Reference

  1. ↑ Burger HG, Igarashi M (April 1988). „Inhibin: definition and nomenclature, including related substances”. Endocrinology 122 (4): 1701–2. DOI:10.1210/endo-122-4-1701. PMID 3345731. 
  2. ↑ „Entrez Gene: INHA inhibin, alpha”. 

Literatura

  • Mellor SL, Richards MG, Pedersen JS i dr.. (1998). „Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer”. J. Clin. Endocrinol. Metab. 83 (3): 969–75. DOI:10.1210/jc.83.3.969. PMID 9506758. 
  • Munz B, Hübner G, Tretter Y i dr.. (1999). „A novel role of activin in inflammation and repair”. J. Endocrinol. 161 (2): 187–93. DOI:10.1677/joe.0.1610187. PMID 10320815. 
  • Welt C, Sidis Y, Keutmann H, Schneyer A (2002). „Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium”. Exp. Biol. Med. (Maywood) 227 (9): 724–52. PMID 12324653. 
  • Shav-Tal Y, Zipori D (2003). „The role of activin a in regulation of hemopoiesis”. Stem Cells 20 (6): 493–500. DOI:10.1634/stemcells.20-6-493. PMID 12456957. 
  • Shao L, Frigon NL, Young AL i dr.. (1992). „Effect of activin A on globin gene expression in purified human erythroid progenitors”. Blood 79 (3): 773–81. PMID 1310063. 
  • Vannelli GB, Barni T, Forti G i dr.. (1992). „Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study”. Cell Tissue Res. 269 (2): 221–7. PMID 1423490. 
  • Matzuk MM, Finegold MJ, Su JG i dr.. (1992). „Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice”. Nature 360 (6402): 313–9. DOI:10.1038/360313a0. PMID 1448148. 
  • Shimonaka M, Inouye S, Shimasaki S, Ling N (1991). „Follistatin binds to both activin and inhibin through the common subunit”. Endocrinology 128 (6): 3313–5. DOI:10.1210/endo-128-6-3313. PMID 2036994. 
  • Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). „Activin B: precursor sequences, genomic structure and in vitro activities”. Mol. Endocrinol. 3 (9): 1352–8. DOI:10.1210/mend-3-9-1352. PMID 2575216. 
  • Barton DE, Yang-Feng TL, Mason AJ i dr.. (1989). „Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice”. Genomics 5 (1): 91–9. DOI:10.1016/0888-7543(89)90091-8. PMID 2767687. 
  • Lappöhn RE, Burger HG, Bouma J i dr.. (1989). „Inhibin as a marker for granulosa-cell tumors”. N. Engl. J. Med. 321 (12): 790–3. DOI:10.1056/NEJM198909213211204. PMID 2770810. 
  • Mayo KE, Cerelli GM, Spiess J i dr.. (1986). „Inhibin A-subunit cDNAs from porcine ovary and human placenta”. Proc. Natl. Acad. Sci. U.S.A. 83 (16): 5849–53. DOI:10.1073/pnas.83.16.5849. PMC 386393. PMID 3016724. 
  • Ramasharma K, Li CH (1987). „Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes”. Proc. Natl. Acad. Sci. U.S.A. 84 (11): 3595–8. DOI:10.1073/pnas.84.11.3595. PMC 304921. PMID 3035540. 
  • Murata M, Eto Y, Shibai H i dr.. (1988). „Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain”. Proc. Natl. Acad. Sci. U.S.A. 85 (8): 2434–8. DOI:10.1073/pnas.85.8.2434. PMC 280011. PMID 3267209. 
  • Burger HG, Igarashi M (1988). „Inhibin: definition and nomenclature, including related substances”. Endocrinology 122 (4): 1701–2. DOI:10.1210/endo-122-4-1701. PMID 3345731. 
  • Mason AJ, Niall HD, Seeburg PH (1986). „Structure of two human ovarian inhibins”. Biochem. Biophys. Res. Commun. 135 (3): 957–64. DOI:10.1016/0006-291X(86)91021-1. PMID 3754442. 
  • Stewart AG, Milborrow HM, Ring JM i dr.. (1986). „Human inhibin genes. Genomic characterisation and sequencing”. FEBS Lett. 206 (2): 329–34. DOI:10.1016/0014-5793(86)81006-7. PMID 3758355. 
  • Xu J, McKeehan K, Matsuzaki K, McKeehan WL (1995). „Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism”. J. Biol. Chem. 270 (11): 6308–13. DOI:10.1074/jbc.270.11.6308. PMID 7890768. 
  • Nishihara T, Okahashi N, Ueda N (1994). „Activin A induces apoptotic cell death”. Biochem. Biophys. Res. Commun. 197 (2): 985–91. DOI:10.1006/bbrc.1993.2576. PMID 8267637. 
  • Mason AJ, Farnworth PG, Sullivan J (1997). „Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A”. Mol. Endocrinol. 10 (9): 1055–65. DOI:10.1210/me.10.9.1055. PMID 8885240. 

Povezano

  • p
  • r
  • u
Endokrine
žlezde
Hipotalamusno-
hipofizni
Druge endokrine
žlezde
Neendokrine
žlezde

M: END

anat/phys/devp/horm/cell

noco(d)/cong/tumr, sysi/epon

proc, lek (A10/H1/H2/H3/H5)