Gama-glutamilna hidrolaza
| Gama-glutamilna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.19.9 | ||||||||
| CAS broj | 9074-87-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Gama-glutamilna hidrolaza (EC 3.4.19.9, konjugaza, folatna konjugaza, lizozomalna gama-glutamilna karboksipeptidaza, gama-Glu-X karboksipeptidaza, pteroil-poli-gama-glutamatna hidrolaza, karboksipeptidaza G, folno kiselinska konjugaza, poli(gama-glutaminsko kiselinska) endohidrolaza, poliglutamatna hidrolaza, poli(glutaminsko kiselinska) hidrolaza II, pteroilpoli-gama-glutamilna hidrolaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza gama-glutamilne veze
Ova lizozomalna ili izlučena, tiol-zavisna peptidaza je najaktivnija na kiselom pH.
Reference
- ↑ McGuire, J.J. and Coward, J.K. (1984). „Pteroylpolyglutamates: biosynthesis, degradation and function.”. u: Blakley, R.L. and Benkovic, S.J.. Folates and Pterins. New York: John Wiley and Sons. str. 135-191.
- ↑ Wang, Y., Nimec, Z., Ryan, T.J., Dias, J.A. and Galivan, J. (1993). „The properties of the secreted γ-glutamyl hydrolases from H35 hepatoma cells”. Biochim. Biophys. Acta 1164: 227-235. PMID 8343522.
- ↑ Yao, R., Rhee, M.S. and Galivan, J. (1995). „Effects of γ-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells”. Mol. Pharmacol. 48: 505-511. PMID 7565632.
- ↑ Yao, R., Schneider, E., Ryan, T.J. and Galivan, J. (1996). „Human γ-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro”. Proc. Natl. Acad. Sci. USA 93: 10134-10138. PMID 8816764.
- ↑ Yao, R., Nimec, Z., Ryan, T.J. and Galivan, J. (1996). „Identification, cloning, and sequencing of a cDNA coding for rat γ-glutamyl hydrolase”. J. Biol. Chem. 271: 8525-8528. PMID 8621474.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- McGuire, J.J. and Coward, J.K. (1984). „Pteroylpolyglutamates: biosynthesis, degradation and function.”. u: Blakley, R.L. and Benkovic, S.J.. Folates and Pterins. New York: John Wiley and Sons. str. 135-191.
Spoljašnje veze
- MeSH Gamma-glutamyl+hydrolase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
