Fibrolaza
| Fibrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.72 | ||||||||
| CAS broj | 116036-70-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fibrolaza (EC 3.4.24.72, fibrinolitička proteinaza, Agkistrodon contortrix contortrix metaloproteinaza, Agkistrodon contortrix contortrix venomna metaloproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -Ala14-Leu- u insulinskom B lancu i -Lys413-Leu- u Aalfa-lancu fibrinogena
Ovaj enzim je prisutan u venumu zmije Agkistrodon contortix contortix.
Reference
- ↑ Retzios, A.D. and Markland, F.S., Jr. (1988). „A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems”. Thromb. Res. 52: 541-552. PMID 3232124.
- ↑ Guan, A.L., Retzios, A.D., Henderson, G.N. and Markland, F.S., Jr. (1991). „Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix)”. Arch. Biochem. Biophys. 289: 197-207. PMID 1898066.
- ↑ Randolph, A., Chamberlain, S.H., Chu, H.L.C., Retzios, A.D., Markland, F.S. (1992). „Jr. and Masiarz, F.R. Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom”. Protein Sci. 1: 590-600. PMID 1304358.
- ↑ Loayza, S.L., Trikha, M., Markland, F.S., Riquelme, P. and Kuo, J. (1994). „Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities”. J. Chromatogr. B Biomed. Appl. 662: 227-243. PMID 7719479.
- ↑ Retzios, A.D. and Markland, F.S. (1994). „Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin”. Thromb. Res. 74: 355-367. PMID 8085237.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Fibrolase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
