Endopeptidaza K
| Endopeptidaza K | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.21.64 | ||||||||
| CAS broj | 39450-01-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Endopeptidaza K (EC 3.4.21.64, Tritirachium alkaline proteinaza, Tritirachium album serin proteinaza, proteinaza K, Tritirachium album proteinaza K) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza keratina, i drugih proteina sa subtilisinu sličnom specifičnošću. Dolazi do hidrolize peptidnih amida
Ovaj enzim je izolovan iz plesni Tritirachium album Limber.
Reference
- ↑ Ebeling, W., Hennrich, N., Klockow, M., Metz, H., Orth, H.D. and Lang, H. (1974). „Proteinase K from Tritirachium album Limber”. Eur. J. Biochem. 47: 91-97. PMID 4373242.
- ↑ Morihara, K. and Tsuzuki, H. (1975). „Specificity of proteinase K from Tritirachium album Limber for synthetic peptides”. Agric. Biol. Chem. 39: 1489-1492.
- ↑ Kraus, E., Klitz, H.H. and Fembert, U.F. (1976). „The specificity of proteinase K against oxidized insulin B chain”. Hoppe-Seyler's Z. Physiol. Chem. 357: 233-237. PMID 943367.
- ↑ Jany, K.-D., Lederer, G. and Mayer, B. (1986). „Amino acid sequence of proteinase K from the mold Tritirachium album Limber”. FEBS Lett. 199: 139-144.
- ↑ Betzel, C., Teplyakov, A.V., Harutyunyan, E.H., Saenger, W. and Wilson, K.S. (1990). „Thermitase and proteinase K: a comparison of the refined three-dimensional structures of the native enzymes”. Protein Engineering 3: 161-172. PMID 2184432.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Peptidase+K
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
