12-O-Tetradekanoilforbol-13-acetat
12-O-Tetradekanoilforbol-13-acetat | |||
---|---|---|---|
IUPAC ime |
| ||
Drugi nazivi | TPA, PMA, Forbol miristat acetat, Tetradekanoilforbol acetat. | ||
Identifikacija | |||
CAS registarski broj | 16561-29-8 Y | ||
PubChem[1][2] | 10475874 | ||
ChemSpider[3] | 17215855 Y | ||
KEGG[4] | C05151 | ||
ChEMBL[5] | CHEMBL279115 Y | ||
Jmol-3D slike | Slika 1 | ||
| |||
| |||
Svojstva | |||
Molekulska formula | C36H56O8 | ||
Molarna masa | 616.83 g mol−1 | ||
Y (šta je ovo?) (verifikuj) Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
12-O-tetradekanoilforbol-13-acetat (TPA) (tetradekanoilforbol acetat, tetradekanoil forbol acetat, forbol 12-miristat 13-acetat, PMA) je diestar forbola i potentan promoter tumora koji se često koristi u biomedicinskim istraživanjima za aktiviranje prenosa signala enzima proteinska kinaza C (PKC).[6][7][8] TPA deluje na PKC usled njegove sličnosti sa prirodnim aktivatorom klasičnih PKC izoformi, diacilglicerolom.
TPA se istražuje kao potencijalni lek za tretman hematološkog kancera.
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Castagna et al (1982). „Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters”. Journal of Biological Chemistry 257 (13): 7847–7851.
- ↑ Blumberg (1988). „Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture”. Cancer Research 48: 1–8.
- ↑ Niedel et al (1983). „Phorbol Diester Receptor Copurifies with Protein Kinase C”. Proceedings of the National Academy of Sciences 80: 36–40. DOI:10.1073/pnas.80.1.36.
Spoljašnje veze
Portal Hemija |
- MeSH Tetradecanoylphorbol+Acetate
- „NCI Dictionary Entry”. Arhivirano iz originala na datum 2005-09-01. Pristupljeno 02. 07. 2005.
- „Phase 1 Clinical Trials”. Pristupljeno 02. 07. 2005.