Aquaporina 1

Aquaporina 1 (Colton blood group)
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1FQY, 1H6I, 1IH5
Identificadores
Símbolos	AQP1; AQP-CHIP; CHIP28; CO
IDs externos	OMIM: 107776 MGI: 103201 HomoloGene: 68051 IUPHAR: AQP1 GeneCards: AQP1 Gene
Ontologia do gene Função molecular •intracellular cGMP activated cation channel activity •potassium channel activity •water transmembrane transporter activity •protein binding •ammonium transmembrane transporter activity •potassium ion transmembrane transporter activity •glycerol transmembrane transporter activity •water channel activity •transmembrane transporter activity •nitric oxide transmembrane transporter activity •carbon dioxide transmembrane transporter activity Componente celular •nucleus •cytoplasm •plasma membrane •integral component of plasma membrane •brush border •basal plasma membrane •basolateral plasma membrane •apical plasma membrane •symbiont-containing vacuole •symbiont-containing vacuole membrane •brush border membrane •nuclear membrane •sarcolemma •apical part of cell •extracellular vesicular exosome Processo biológico •renal water transport •cGMP biosynthetic process •potassium ion transport •water transport •cell volume homeostasis •carbon dioxide transport •ammonium transport •bicarbonate transport •glycerol transport •cellular homeostasis •lateral ventricle development •pancreatic juice secretion •nitric oxide transport •establishment or maintenance of actin cytoskeleton polarity •cerebrospinal fluid secretion •cellular response to stress •cellular response to UV •transepithelial water transport •carbon dioxide transmembrane transport •odontogenesis •response to drug •negative regulation of apoptotic process •negative regulation of cysteine-type endopeptidase activity involved in apoptotic process •small molecule metabolic process •positive regulation of angiogenesis •positive regulation of saliva secretion •positive regulation of fibroblast proliferation •multicellular organismal water homeostasis •transmembrane transport •cellular response to hydrogen peroxide •cellular response to inorganic substance •cellular response to mechanical stimulus •cellular response to copper ion •cellular response to mercury ion •cellular response to retinoic acid •cellular response to cAMP •cellular response to hypoxia •cellular response to salt stress •cellular hyperosmotic response •cellular response to dexamethasone stimulus •cellular response to nitric oxide •potassium ion transmembrane transport •ammonium transmembrane transport •maintenance of symbiont-containing vacuole by host Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	358	11826
Ensembl	ENSG00000240583	ENSMUSG00000004655
UniProt	P29972	Q02013
RefSeq (mRNA)	NM_000385	NM_007472
RefSeq (proteína)	NP_001171989	NP_031498
Localização (UCSC)	Chr 7: 30.89 – 30.97 Mb	Chr 6: 55.34 – 55.35 Mb
Busca PubMed	[1]	[2]
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A aquaporina 1 (AQP1) é um canal de água amplamente expresso em células, e cujas funções fisiológicas nos rins têm sido muito estudadas.

É encontrada na membrana basolateral e na membrana apical dos túbulos próximais, na porção descendente da alça de Henle e na porção descendente dos capilares peritubulares (vasa recta).

É adicionalmente encontrada em eritrócitos, no endotélio vascular, no tracto gastrointestinal, glândulas sudoríparas e nos pulmões.

Esta proteína não sofre regulação pela vasopressina