YAP1(yes-associated protein 1)は、転写因子として機能するタンパク質であり、細胞増殖に関与する遺伝子の転写を活性化しアポトーシスに関与する遺伝子を抑制する。YAP、YAP65とも呼ばれる。YAP1は、器官のサイズの制御や腫瘍の抑制を可能にするHippoシグナル伝達経路によって阻害される。YAP1はYes(英語版)やSrcといったチロシンキナーゼのSH3ドメインに結合することから初めて同定された[5]。YAP1をコードするYAP1遺伝子は強力ながん遺伝子であり、ヒトのさまざまながんで増幅されている[6][7]。
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