RIPK1 |
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PDBに登録されている構造 |
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PDB | オルソログ検索: RCSB PDBe PDBj |
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PDBのIDコード一覧 |
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4ITH, 4ITI, 4ITJ, 4NEU, 5HX6 |
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識別子 |
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記号 | RIPK1, RIP, RIP1, RIP-1, receptor interacting serine/threonine kinase 1, IMD57, AIEFL |
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外部ID | OMIM: 603453 MGI: 108212 HomoloGene: 2820 GeneCards: RIPK1 |
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遺伝子の位置 (ヒト) |
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| 染色体 | 6番染色体 (ヒト)[1] |
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| バンド | データ無し | 開始点 | 3,063,824 bp[1] |
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終点 | 3,115,187 bp[1] |
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遺伝子の位置 (マウス) |
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| 染色体 | 13番染色体 (マウス)[2] |
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| バンド | データ無し | 開始点 | 34,186,346 bp[2] |
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終点 | 34,221,130 bp[2] |
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遺伝子オントロジー |
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分子機能 | • トランスフェラーゼ活性 • protein kinase activity • ヌクレオチド結合 • death domain binding • キナーゼ活性 • protein serine/threonine kinase activity • 血漿タンパク結合 • identical protein binding • ATP binding • ubiquitin protein ligase binding • シグナルトランスデューサー活性 • protein-containing complex binding • death receptor binding • JUN kinase kinase kinase activity
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細胞の構成要素 | • 膜 • receptor complex • 細胞膜 • ミトコンドリア • 細胞死誘導シグナル伝達複合体 • 脂質ラフト • 細胞質 • 細胞質基質 • endosome membrane • ripoptosome • 高分子複合体
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生物学的プロセス | • T cell apoptotic process • positive regulation of protein phosphorylation • amyloid fibril formation • positive regulation of cell death • リン酸化 • regulation of ATP:ADP antiporter activity • peptidyl-serine autophosphorylation • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of macrophage differentiation • cellular response to tumor necrosis factor • cellular response to growth factor stimulus • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of programmed cell death • tumor necrosis factor-mediated signaling pathway • positive regulation of JNK cascade • regulation of reactive oxygen species metabolic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • TRIF-dependent toll-like receptor signaling pathway • response to tumor necrosis factor • positive regulation of necroptotic process • タンパク質リン酸化 • positive regulation of reactive oxygen species metabolic process • death-inducing signaling complex assembly • positive regulation of NF-kappaB transcription factor activity • necroptotic signaling pathway • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of extrinsic apoptotic signaling pathway • 自己リン酸化 • regulation of extrinsic apoptotic signaling pathway via death domain receptors • ネクロトーシス(またはネクロプトーシス) • positive regulation of phosphorylation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • I-kappaB kinase/NF-kappaB signaling • activation of cysteine-type endopeptidase activity involved in apoptotic process • protein homooligomerization • positive regulation of transcription by RNA polymerase II • ripoptosome assembly • シグナル伝達 • positive regulation of MAPK cascade • positive regulation of hydrogen peroxide-induced cell death • apoptotic signaling pathway • アポトーシス • プログラム細胞死 • extrinsic apoptotic signaling pathway • positive regulation of necrotic cell death • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • protein deubiquitination • ripoptosome assembly involved in necroptotic process • MyD88-independent toll-like receptor signaling pathway • toll-like receptor 3 signaling pathway • viral process • protein heterooligomerization • MAPK cascade • negative regulation of cardiac muscle cell proliferation • cellular response to hydrogen peroxide • programmed necrotic cell death • positive regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of production of miRNAs involved in gene silencing by miRNA • negative regulation of G1/S transition of mitotic cell cycle
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出典:Amigo / QuickGO |
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オルソログ |
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種 | ヒト | マウス |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_003804 NM_001317061 NM_001354930 NM_001354931 NM_001354932
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NM_001354933 NM_001354934 |
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RefSeq (タンパク質) | NP_001303990 NP_003795 NP_001341859 NP_001341860 NP_001341861
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NP_001341862 NP_001341863 |
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場所 (UCSC) | Chr 6: 3.06 – 3.12 Mb | Chr 6: 34.19 – 34.22 Mb |
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PubMed検索 | [3] | [4] |
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ウィキデータ |
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