Akuaporin 3

AQP3
Pengidentifikasi
AliasAQP3, AQP-3, GIL, aquaporin 3 (Gill blood group)
ID eksternalOMIM: 600170 MGI: 1333777 HomoloGene: 21025 GeneCards: AQP3
Ontologi gen
Fungsi molekuler• aktivitas saluran air
• glycerol channel activity
• aktivitas transporter
• aktivitas saluran
• urea transmembrane transporter activity
Komponen seluler• sitoplasma
• komponen integral membran
• membran
• cell-cell junction
• Membran sel
• membran plasma basolateral
• Inti sel
Proses biologis• positive regulation of immune system process
• Ekskresi
• respons terhadap vitamin D
• respons terhadap asam retinoat
• transpor air
• urea transport
• odontogenesis
• response to calcium ion
• renal water homeostasis
• regulation of keratinocyte differentiation
• renal water absorption
• glycerol transport
• cellular response to oxygen-glucose deprivation
• respons seluler terhadap hipoksia
• transpor transmembran
• urea transmembrane transport
Sumber:Amigo / QuickGO
Ortolog
SpesiesManusiaTikus
Entrez

360

11828

Ensembl

ENSG00000165272

ENSMUSG00000028435

UniProt

Q92482

Q8R2N1

RefSeq (mRNA)

NM_004925
NM_001318144

NM_016689

RefSeq (protein)

NP_001305073
NP_004916

NP_057898

Lokasi (UCSC)n/an/a
Pencarian PubMed[1][2]
Wikidata
Lihat/Sunting ManusiaLihat/Sunting Tikus

Akuaporin 3 ditemukan pada membran sel basolateral sel utama tubulus koligentes dan menyediakan jalur bagi air untuk keluar dari sel tersebut.[3] Di dalam ginjal, AQP3 diregulasi oleh vasopresin (ADH).[4] Protein ini juga merupakan determinan untuk sistem golongan darah GIL.[5]

Asam suberanilohidroksamat (SAHA) (inhibitor HDAC) meningkatkan ekspresi akuaporin-3 pada sel kulit normal (keratinosit).[6]

Signifikansi klinis

Konsentrasi AQP3 sering kali lebih rendah pada psoriasis dibandingkan dengan kulit sehat.[6]

AQP3 lebih diekspresikan pada eksem atopik.[7]

Lihat pula

  • Akuaporin

Referensi

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct". Annu. Rev. Physiol. 60: 199–220. doi:10.1146/annurev.physiol.60.1.199. PMID 9558461. 
  4. ^ Baynes JW, Dominiczak MH (2014). "Medical Biochemistry". Medical Biochemistry (Textbook) (edisi ke-4): 346 – via Elsevier. 
  5. ^ Roudier N, Ripoche P, Gane P, Le Pennec PY, Daniels G, Cartron JP, Bailly P (2002). "AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL". J. Biol. Chem. 277 (48): 45854–9. doi:10.1074/jbc.M208999200. PMID 12239222. 
  6. ^ a b Cancer therapy shows promise for psoriasis treatment
  7. ^ Olsson M, Broberg A, Jernãs M, et al. (2006). "Increased expression of aquaporin 3 in atopic eczema". Allergy. 61 (9): 1132–7. doi:10.1111/j.1398-9995.2006.01151.x. PMID 16918518. 

Bacaan lanjutan

  • Bietz S, Montilla I, Külzer S, et al. (2009). "Recruitment of human aquaporin 3 to internal membranes in the Plasmodium falciparum infected erythrocyte". Mol. Biochem. Parasitol. 167 (1): 48–53. doi:10.1016/j.molbiopara.2009.04.006. PMID 19393693. 
  • Bahamontes-Rosa N, Tena-Tomás C, Wolkow J, et al. (2008). "Genetic conservation of the GIL blood group determining aquaporin 3 gene in African and Caucasian populations". Transfusion. 48 (6): 1164–8. doi:10.1111/j.1537-2995.2008.01683.x. PMID 18435676. 
  • Wang S, Amidi F, Beall M, et al. (2006). "Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture". J. Soc. Gynecol. Investig. 13 (3): 181–5. doi:10.1016/j.jsgi.2006.02.002. PMID 16638588. 
  • Ben Y, Chen J, Zhu R, et al. (2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells". Respiratory physiology & neurobiology. 161 (2): 111–8. doi:10.1016/j.resp.2007.12.007. PMID 18280225. 
  • Yasui H, Kubota M, Iguchi K, et al. (2008). "Membrane trafficking of aquaporin 3 induced by epinephrine". Biochem. Biophys. Res. Commun. 373 (4): 613–7. doi:10.1016/j.bbrc.2008.06.086. PMID 18601899. 
  • Horie I, Maeda M, Yokoyama S, et al. (2009). "Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes". Biochem. Biophys. Res. Commun. 387 (3): 564–8. doi:10.1016/j.bbrc.2009.07.077. PMID 19619514. 
  • Bellemère G, Von Stetten O, Oddos T (2008). "Retinoic acid increases aquaporin 3 expression in normal human skin". J. Invest. Dermatol. 128 (3): 542–8. doi:10.1038/sj.jid.5701047. PMID 17943189. 
  • Cohly HH, Isokpehi R, Rajnarayanan RV (2008). "Compartmentalization of aquaporins in the human intestine". Int J Environ Res Public Health. 5 (2): 115–9. doi:10.3390/ijerph5020115. PMC 2694936 alt=Dapat diakses gratis. PMID 18678926. 
  • Lee TC, Ho IC, Lu WJ, Huang JD (2006). "Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line". J. Biol. Chem. 281 (27): 18401–7. doi:10.1074/jbc.M601266200. PMID 16672223. 
  • Hara-Chikuma M, Verkman AS (2008). "Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing". J. Mol. Med. 86 (2): 221–31. doi:10.1007/s00109-007-0272-4. PMID 17968524. 
  • Hara-Chikuma M, Takahashi K, Chikuma S, et al. (2009). "The expression of differentiation markers in aquaporin-3 deficient epidermis". Arch. Dermatol. Res. 301 (3): 245–52. doi:10.1007/s00403-009-0927-9. PMC 3582396 alt=Dapat diakses gratis. PMID 19184071. 
  • Wang J, Tanji N, Kikugawa T, et al. (2007). "Expression of aquaporin 3 in the human prostate". Int. J. Urol. 14 (12): 1088–92; discussion 1092. doi:10.1111/j.1442-2042.2007.01901.x. PMID 18036046. 
  • Higuchi S, Kubota M, Iguchi K, et al. (2007). "Transcriptional regulation of aquaporin 3 by insulin". J. Cell. Biochem. 102 (4): 1051–8. doi:10.1002/jcb.21350. PMID 17471492. 
  • Tancharoen S, Matsuyama T, Abeyama K, et al. (2008). "The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation". J. Cell. Physiol. 217 (2): 338–49. doi:10.1002/jcp.21506. PMID 18543247. 
  • Richardson SM, Knowles R, Marples D, et al. (2008). "Aquaporin expression in the human intervertebral disc". J. Mol. Histol. 39 (3): 303–9. doi:10.1007/s10735-008-9166-1. PMID 18247144. 
  • Avril-Delplanque A, Casal I, Castillon N, et al. (2005). "Aquaporin-3 expression in human fetal airway epithelial progenitor cells". Stem Cells. 23 (7): 992–1001. doi:10.1634/stemcells.2004-0197. PMID 16043462. 
  • Kida H, Miyoshi T, Manabe K, et al. (2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line". J. Membr. Biol. 208 (1): 55–64. doi:10.1007/s00232-005-0819-7. PMID 16596446. 
  • Liu YL, Matsuzaki T, Nakazawa T, et al. (2007). "Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues". Hum. Pathol. 38 (1): 171–8. doi:10.1016/j.humpath.2006.07.015. PMID 17056099. 

Pranala luar

  • Sistem golongan darah GIL pada Basis Data Mutasi Gen Antigen Golongan Darah BGMUT di NCBI, NIH
  • Lokasi genom AQP3 manusia dan halaman rincian gen AQP3 dalam UCSC Genome Browser.


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