CSF1R |
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Structure de la protéine CSF1R. Basé sur l'identifiant PDB 2I0V. |
Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM |
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Identifiants |
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Aliases | CSF1R, Colony stimulating factor 1 receptor |
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IDs externes | OMIM: 164770 MGI: 1339758 HomoloGene: 3817 GeneCards: CSF1R |
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Nomenclature EC | 2.7.10.1 |
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Position du gène (Homme) |
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| Chr. | Chromosome 5 humain[1] |
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| Locus | 5q32 | Début | 150,053,291 bp[1] |
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Fin | 150,113,372 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 18 (souris)[2] |
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| Locus | 18 E1|18 34.41 cM | Début | 61,233,670 bp[2] |
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Fin | 61,265,221 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - granulocyte
- monocyte
- rate
- artère coronaire droite
- placenta
- ganglion inférieur du nerf vague
- épithélium pigmentaire rétinien
- vésicule biliaire
- appendice iléo-cæcal
- ganglion lymphatique
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| Fortement exprimé dans | - stroma of bone marrow
- épithélium pigmentaire rétinien
- cheville
- motoneurone
- tibiofemoral joint
- artère carotide interne
- calvaria
- substantia nigra
- gastrula
- globus pallidus
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| Plus de données d'expression de référence |
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BioGPS | | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison nucléotide
- protein tyrosine kinase activity
- protein kinase activity
- activité de transférase
- transmembrane receptor protein tyrosine kinase activity
- activité kinase
- protein homodimerization activity
- liaison ATP
- protein phosphatase binding
- macrophage colony-stimulating factor receptor activity
- cytokine binding
- liaison protéique
- Récepteurs à activité tyrosine kinase
- transmembrane signaling receptor activity
| Composant cellulaire | - integral component of membrane
- integral component of plasma membrane
- membrane
- surface cellulaire
- CSF1-CSF1R complex
- nucléoplasme
- membrane plasmique
- intracellular membrane-bounded organelle
- cytoplasme
- receptor complex
| Processus biologique | - negative regulation of cell population proliferation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of protein serine/threonine kinase activity
- mammary gland duct morphogenesis
- positive regulation of cell motility
- macrophage colony-stimulating factor signaling pathway
- phosphatidylinositol-mediated signaling
- negative regulation of apoptotic process
- positive regulation of ERK1 and ERK2 cascade
- transduction de signal
- Guidage axonal
- développent d'un organisme multicellulaire
- monocyte differentiation
- macrophage differentiation
- ruffle organization
- positive regulation of cell migration
- cellular response to cytokine stimulus
- protein autophosphorylation
- peptidyl-tyrosine phosphorylation
- olfactory bulb development
- regulation of bone resorption
- phosphatidylinositol metabolic process
- phosphorylation des protéines
- positive regulation of protein tyrosine kinase activity
- cell-cell junction maintenance
- osteoclast differentiation
- système immunitaire inné
- regulation of actin cytoskeleton reorganization
- processus du système immunitaire
- réponse inflammatoire
- positive regulation of protein phosphorylation
- forebrain neuron differentiation
- phosphorylation
- cellular response to macrophage colony-stimulating factor stimulus
- positive regulation of cell population proliferation
- regulation of cell shape
- prolifération cellulaire
- positive regulation of tyrosine phosphorylation of STAT protein
- cytokine-mediated signaling pathway
- hématopoïèse
- negative regulation of signal transduction
- différenciation cellulaire
- hematopoietic progenitor cell differentiation
- positive regulation of MAPK cascade
- response to ischemia
- microglial cell proliferation
- positive regulation by host of viral process
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001288705 NM_005211 NM_001349736 NM_001375320 NM_001375321 |
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RefSeq (protéine) | |
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NP_001275634 NP_005202 NP_001336665 NP_001362249 NP_001362250 |
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Localisation (UCSC) | Chr 5: 150.05 – 150.11 Mb | Chr 18: 61.23 – 61.27 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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